Erythema‐multiforme‐like eruption following allergic contact dermatitis from sesquiterpene luctones in herbal medicine

Mateo, M P Gil; Saavedra-Velasco, Marcos; Miquel, F.J. Miquel; Cuadra, J. de la

doi:10.1111/j.1600-0536.1995.tb02100.x

Cited by 29 publications

(14 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An erythema-multiforme-like eruption was observed in a 31year-old woman after a 'herbal bag' had been applied for back pain; patch tests with Inula helenium were positive, demonstrating the responsibility of this compound [32]. An erythema-multiforme-like eruption was observed in a 31year-old woman after a 'herbal bag' had been applied for back pain; patch tests with Inula helenium were positive, demonstrating the responsibility of this compound [32].…”

Section: Herbal Remediesmentioning

confidence: 98%

Hypersensitivity Reactions to Complementary and Alternative Medicine Products

Ventura¹,

Viola²,

Calogiuri³

et al. 2006

CPD

View full text Add to dashboard Cite

Complementary and alternative medicine (CAM) is becoming increasingly popular, and is often used for treating hypersensitivity diseases. Virtually all alternative remedies can cause hypersensitivity reactions, but the most frequently involved ones are tea tree oil, members of the Compositae family, propolis, oils used in aromatherapy, substances responsible for photosensitization, and metal-containing compounds. The main target organ is skin, with manifestations ranging from contact dermatitis (the most common) to urticaria-angioedema, maculopapular eruptions, photosensitivity reactions, and the Stevens-Johnson syndrome. Other types of reactions are possible, including respiratory and anaphylactic ones. Different pathogenic mechanisms have been suggested for CAM product reactions, including immunologic ones. Basophils and mast cells participate in IgE-mediated reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most delayed reactions, particularly contact dermatitis and maculopapular eruptions. Skin tests and serum specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while patch tests and lymphocyte transformation tests are usually performed to evaluate delayed hypersensitivity reactions. Thus clinicians should know about the potential of CAM products for causing adverse reactions. Our study is aimed at highlighting the risk of hypersensitive reactions to CAM remedies on the basis of the numerous cases reported in the literature. Because little is known about adverse reactions to CAM products, further systematic studies and an appropriate regulation by heath authorities are necessary.

show abstract

Section: Herbal Remediesmentioning

confidence: 98%

Hypersensitivity Reactions to Complementary and Alternative Medicine Products

Ventura¹,

Viola²,

Calogiuri³

et al. 2006

CPD

View full text Add to dashboard Cite

show abstract

“…The allergens were licorice root ( Glycyrrhiza uralensis ) and probably elecampane, though the use of high patch test concentrations of elecampane extracts introduced an element of possible irritation (69). Gil Mateo et al reported a case of acute eczema due to a ‘herbal bag’, and Pazzaglia et al another case of dermatitis due to a herbal massage liniment (13, 70). Both patients were positive to the SL mix and alantolactone; the latter patient may also have been sensitized to burdock milfoil or bay leaf present in the massage liniment, but was not tested with these (13).…”

Section: Inula Helenium L(elecampane; Inci Name Inula Helenium)mentioning

confidence: 99%

Contact sensitization from Compositae‐containing herbal remedies and cosmetics

Paulsen

2002

Contact Dermatitis

141

View full text Add to dashboard Cite

The Compositae (Asteraceae) family of plants is currently an important cause of allergic plant contact dermatitis in Europe. The family comprises some of the oldest and most valued medicinal plants, and the increasing popularity of herbal medicine and cosmetics may theoretically result in a growing number of Compositae sensitizations from these sources. According to the literature at least 15 species, including among others arnica (Arnica montana), German and Roman chamomile (Chamomilla recutita and Chamaemelum nobile), marigold (Calendula officinalis), Echinacea and elecampane (Inula helenium), have been suspected of sensitization or elicitation of Compositae dermatitis. Epidemiological data are available for 2 species only, arnica and German chamomile, the rest of the evidence being anecdotal. Based on this, sensitization seems to occur relatively frequently with a few species such as arnica and elecampane, and occurs rarely with the majority, especially the widely used German chamomile. Sesquiterpene lactones are the most important allergens, but there are a few cases of sensitization from a coumarin, a sesquiterpene alcohol and a thiophene. The risk of elicitation of dermatitis by using Compositae-containing products in Compositae-sensitive individuals is by-and-large unknown.

show abstract

“…Tincture of capsicum caused an analogous reaction in a woman who used the concoction to treat her knee arthritis [18]. Inula helenium , contained in a mixture to treat back pain, has also induced erythema multiforme-like eruption, with positive patch tests to sesquiterpene lactone mix and alantolactone [19]. Notably, Primula obconica can also induce comparable eruptions [20–23].…”

Section: Erythema Multiforme-like Contact Dermatitismentioning

confidence: 99%

Noneczematous Contact Dermatitis

et al. 2013

View full text Add to dashboard Cite

Irritant or allergic contact dermatitis usually presents as an eczematous process, clinically characterized by erythematoedematovesicous lesions with intense itching in the acute phase. Such manifestations become erythematous-scaly as the condition progresses to the subacute phase and papular-hyperkeratotic in the chronic phase. Not infrequently, however, contact dermatitis presents with noneczematous features. The reasons underlying this clinical polymorphism lie in the different noxae and contact modalities, as well as in the individual susceptibility and the various targeted cutaneous structures. The most represented forms of non-eczematous contact dermatitis include the erythema multiforme-like, the purpuric, the lichenoid, and the pigmented kinds. These clinical entities must obviously be discerned from the corresponding “pure” dermatitis, which are not associated with contact with exogenous agents.

show abstract

Erythema‐multiforme‐like eruption following allergic contact dermatitis from sesquiterpene luctones in herbal medicine

Cited by 29 publications

References 7 publications

Hypersensitivity Reactions to Complementary and Alternative Medicine Products

Hypersensitivity Reactions to Complementary and Alternative Medicine Products

Contact sensitization from Compositae‐containing herbal remedies and cosmetics

Noneczematous Contact Dermatitis

Contact Info

Product

Resources

About