Erythema Multiforme from Tedania Ignis

Diet of the queen angelfish Holacanthus ciliaris (Pomacanthidae) in São Pedro e São Paulo Archipelago, Brazil

“…However, T. ignis produces toxic chemicals that cause dermatitis in humans (e.g. Yaffee & Stargardter, 1963) and the spicules of G. neptuni deterred feeding by the Red Sea generalist fish Thalassoma klunzingeri (Fowler & Steintitz)—although they have no effects on its Western Atlantic counterpart T. bifasciatum (Bloch) or on a natural assembly of predators (Chanas & Pawlik, 1995, 1996; Burns & Ilan, 2003). The green alga C. racemosa has no chemical defences (Wylie & Paul, 1988; Paul et al , 1990), but the variety peltata found in SPSPA has not yet been tested for anti-feeding properties.…”

Tedanol: A potent anti-inflammatory ent-pimarane diterpene from the Caribbean Sponge Tedania ignis

“…The reaction was allowed to proceed for 18 h at room temperature, and the reaction mixture was then dried under vacuum, giving 0.6 mg of tedanol 7-O-acetate (2): colorless amorphous solid; 1 …”

“…Dermatites have also been reported to occur as a consequence of the contact with the sponge tissue. 1 It has not been determined so far which chemicals cause rash and dermatitis. Previous analyses of Caribbean samples of T. ignis led to the isolation of a new atisane derivative, 2 several diketopiperazines, 2,3 and some carbazole and carboline derivatives.…”

“…Elucidation of the pimarane skeleton of tedanol(1). Part structures determined from HMBC correlations of angular methyl protons are denoted with bold lines, and bond determined from COSY correlations are denoted with solid lines.…”

Loxosomella from Tedania ignis, the Caribbean fire sponge

“…Most human beings, when handling the sponge, experience skin irritations of varying degrees. A severe erythema multiforme reaction on a man after handling Tedania ignis from Bermuda was reported by Yaffee and Stargardter (1963).…”