Erythema multiforme following application of hair dye

Koley, Sankha; Sarkar, Jyotirindranath; Choudhary, Sanjiv; Dhara, Suparna; Choudhury, M. G. M.

doi:10.4103/0019-5154.96209

Cited by 10 publications

(8 citation statements)

References 9 publications

(9 reference statements)

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“…EM is an acute mucocutaneous hypersensitivity reaction with varying degrees of blistering and ulceration. Common causes of EM are herpes simplex virus infection, mycoplasma infection, drug hypersensitivity, vaccination and drug-virus interaction (5). Although EM is a rare complication of orf, it was the main complaint that led our patients to the hospital.…”

Section: Introductionmentioning

confidence: 92%

Erythema Multiforme Developing Secondary to Orf Disease: Ten Cases

Aktaş¹,

Uçmak²,

Akkurt³

et al. 2018

tdd

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Section: Introductionmentioning

confidence: 92%

Erythema Multiforme Developing Secondary to Orf Disease: Ten Cases

Aktaş¹,

Uçmak²,

Akkurt³

et al. 2018

tdd

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“…Inflammation is one of the major hallmarks of cancer, and inflammatory signaling can modulate the transcription and translation of several pro- and anti-inflammatory cytokines that play a role in tumorigenesis [ 50 ]. To investigate whether inflammatory signaling pathways were altered in IRF9-deficient mice after DSS administration, we measured the activation of NF-κB and p38 mitogen activated protein kinase (MAPK) and found them to be similar in the colon of WT and IRF9-deficient mice 14 days after AOM/DSS treatment ( Figure 3 A).…”

Section: Resultsmentioning

confidence: 99%

The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis

Sharma

Karki

Sundaram

et al. 2022

Cancers

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Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, and innate immune responses and inflammation are known to affect the course of disease. Interferon (IFN) signaling in particular is critical for modulating inflammation-associated diseases including CRC. While the effects of IFN signaling in CRC have been studied, results have been conflicting. Furthermore, individual molecules in the IFN pathway that could be therapeutically targeted have distinct functions, with many of their diverse roles in CRC remaining unclear. Here, we found that IRF9 had an oncogenic effect in CRC; loss of IRF9 reduced tumorigenesis in both azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced and spontaneous CRC models. IRF9 also reduced DSS-induced colitis and inflammation in the colon, but it had no effect on the NF-κB and MAPK signaling activation. Instead, IRF9 enhanced the transcription and production of the inflammatory cytokine IL-6. By promoting IL-6 release, IRF9 drove the activation of pro-oncogenic STAT3 signaling in the colon. Overall, our study found that IRF9 promoted the development of CRC via modulation of the IL-6/STAT3 signaling axis, identifying multiple potential targets and suggesting new therapeutic strategies for the treatment of CRC.

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“…When added to henna, the concentration of PPD is often much higher than what is approved for use in hair dyes. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme-like secondary to paraphenylenediamine due to henna tattoo plus residual hypopigmentation

et al. 2015

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Temporary henna tattoos or pseudotattoos have become increasingly widespread among children and adolescent. A generalized skin reaction, type erythema multiforme-like reaction is unusual, and rarely reported. We describe the case of a 7-year-old boy who reported erythematous papular bull’s-eye shaped lesions and consolidated edema primarily in the upper and lower extremities. These lesions were compatibles with erythema multiforme-like reaction. He also showed an erythematous-eczematous lesion on his leg, shaped like a dolphin. In this area, a temporary henna tattoo was painted 1-month earlier. Patch test was positive for paraphenylenediamine (PPD). Skin reactions due to henna are rare. Most of the reactions are due to additives, especially PPD, an aniline derivative, which is added to speed up the process of skin dyeing and to give a darker brown to black color (“black” henna). As henna tattoos are becoming increasingly popular, prevention requires the annual provision of information to consumers, especially young people and their parents.

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Erythema multiforme following application of hair dye

Cited by 10 publications

References 9 publications

Erythema Multiforme Developing Secondary to Orf Disease: Ten Cases

Erythema Multiforme Developing Secondary to Orf Disease: Ten Cases

The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis

Erythema multiforme-like secondary to paraphenylenediamine due to henna tattoo plus residual hypopigmentation

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