Erythema multiforme: Clinical, histopathologic, and immunologic study

Howland, William W; Golttz, Loren E; Weston, William L.; Huff, J. Clark

doi:10.1016/s0190-9622(84)80090-0

Cited by 148 publications

(59 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No toxicity related to these diseases has been recognized in trials of over 10,000 persons, but brief review is warranted, given the increasing use of potent adjuvants and targeting of cellular immunity in contemporary vaccination trials. HAEM refers to episodic erythema multiforme skin lesions that occur in a pattern that is temporally, although not spatially, correlated with typical recurrent HSV infection (109). An estimated 50 to 80% of cases of recurrent erythema multiforme are HSV-associated (109).…”

Section: Potential Toxicities Of Vaccinesmentioning

confidence: 99%

“…HAEM refers to episodic erythema multiforme skin lesions that occur in a pattern that is temporally, although not spatially, correlated with typical recurrent HSV infection (109). An estimated 50 to 80% of cases of recurrent erythema multiforme are HSV-associated (109). A causal role for recurrent HSV infection has been strongly suggested by the clinical improvement that occurs when suppressive doses of nucleoside antivirals are given (147).…”

Section: Potential Toxicities Of Vaccinesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research

2003

View full text Add to dashboard Cite

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, focusing on genital infection with HSV-2. Several protein subunit vaccines based on HSV-2 envelope glycoproteins have reached advanced-phase clinical trials. These antigens were chosen because they are the targets of neutralizing-antibody responses and because they elicit cellular immunity. Encouraging results have been reported in studies of treatment of HSV-seronegative women with a vaccine consisting of truncated glycoprotein D of HSV-2 and a novel adjuvant. Because most sexual HSV transmission occurs during asymptomatic shedding, it is important to evaluate the impact of vaccination on HSV-2 infection, clinically apparent genital herpes, and HSV shedding among vaccine recipients who acquire infection. There are several other attractive formats, including subunit vaccines that target cellular immune responses, live attenuated virus strains, and mutant strains that undergo incomplete lytic replication. HSV vaccines have also been evaluated for the immunotherapy of established HSV infection

show abstract

Section: Potential Toxicities Of Vaccinesmentioning

confidence: 99%

Section: Potential Toxicities Of Vaccinesmentioning

confidence: 99%

Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research

2003

View full text Add to dashboard Cite

show abstract

“…Histological examination and immunostaining often shows moderate to dense perivascular inflammatory infiltrate (CD4? lymphocytes and histocytes) within the papillary dermis and along the dermoepidermal junction, dermal edema, intraepithelial/subepithelial vesicles and/or bullae, hydropic degeneration of basal keratinocytes and non-specific immune deposits of IgM, C3 and fibrin along basement membrane [3,17]. Direct and indirect immunofluorescence is generally unhelpful other than to exclude other vesiculobullous disorders.…”

Section: Discussionmentioning

confidence: 99%

Erythema Multiforme-Oral Variant: Case Report and Review of Literature

Kohli

Kaur

2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Erythema multiforme (EM) is an interesting dermatologic disease which has oral manifestations. EM is clinically characterized by a ''minor'' form and a ''major'' form. It presents a diagnostic dilemma because the oral cavity has the ability to produce varied manifestations. Infections (particularly herpes simplex and mycoplasma pneumonia) and drugs seem to predispose toward the development of EM. The range of possible etiologies for oral disease is immense. Therefore, an otolaryngologist or a dentist while treating such patients should have a differential diagnosis for all oral lesions. We report a case of erythema multiforme in which alcohol (ethanol) seems to be the precipitating factor and have also reviewed the English literature in the present context.

show abstract

“…The skin lesions of EM usually appear symmetrically on the distal extremities and progress proximally [23]. Lesions on the dorsal surfaces of the hands and extensor aspects of the extremities are most characteristic [21].…”

Section: Clinical Presentationsmentioning

confidence: 99%