Erythema multiforme and Kawasaki disease associated with COVID‐19 infection in children

Abstract

Hence, corticosteroids could have prevented the initial development of AEGP. Lastly, to date SCARs have been reported with the use of ceftriaxone, but there is only one reported case of DRESS related to cefditoren, among other causes. 4,5 Surrounding the COVID-19 pandemic, many dermatoses are being reported as possibly SARS-CoC-2 induced. Here, we highlight the importance of considering other etiologies as causes of skin lesions arising on the background of SARS-CoV-2 infection. Special effort has to be made to identify drugs as the source of these events, as they may lead to SCARs. Finally, further studies should investigate cross-reactions between cephalosporins, and the role of cefditoren as causative agent of SCARs.

Cutaneous manifestations associated with COVID-19 in children: A Systematic Review

“…The varied cutaneous presentations, histopathological ndings, and other details are tabulated in table 3. Reference [16], [19], [20], [21], [24], [25], [26], [27] [17], [18], [ The majority of the children showed erythematous maculopapular eruptions, which is generally the commonest cutaneous presentation in any viral illness, however, a closer look in our study subjects throws up several contradicting observations. For instance, instead of general cephalocaudal distribution in any viral exanthem, here the cases showed involvement of acral region of feet and hands.…”

“…[22] Generalized exanthematous lesion with palmer edema, cervical lymphadenopathy, glossitis and desquamation of extremities; Kawasaki disease like presentation, was reported in a 3 years male child with negative RT PCR but ground glass consolidation in CT chest suggestive of COVID pneumonia. [18] Additionally, Bursal et al reported non-acral erythematous maculopapular rash starting on the face and extending to trunk and extremities in 3 of their COVID positive patients. [28] The site of lesion was feet alone in 120 cases, mostly at the dorsal surface of toes & sometimes on the lateral margin of feet.…”

“…URI and GI symptoms together were present in 10 cases. Radiologic evidence of pneumonia was present in 2 patients; both were under 5 years of age and negative for RT PCR (16,18). The incubation period varied from less than 10 days (n=10) to 30 days (n=32) with more than 60 days in a 5-year-old boy having pneumonia but negative RT PCR.…”

“…[11], [12] [13], [14] [15] Thus, a total of 13 articles met the inclusion criteria and were systematically reviewed. Out of that 5 were case series, [16], [17] [18], [19] [20] 4 were case reports, [21], [22] [23], [24] and 4 were original studies. [25], [26] [27], [28] Maximum number of articles were reported from Italy, [16], [19] [20], [21] [22], [24] [26] followed by Spain, [17] [23], [25] France, [8] Turkey, [28] and USA.…”

Covid-19 in Peru: from supervised walks for children to the first case of Kawasaki-like syndrome

“…Similarly, in Peru the cases in children under 11 increased from 1.9% of total cases on 12 May10 to 2.6% on 26 May11 and from 1.1% to 1.6% in 12-17 year olds. This happened as Kawasaki-like cases with prolonged fever, rash, and hyperinflammatory shock in young children started to be reported in Europe12131415 and the United States 1617. On 14 May, this syndrome was called multisystem inflammatory syndrome in children (MIS-C) 18.…”