Erythema multiforme after CoronaVac vaccination

Abstract

cases, the patients had a personal or family history of atopy, perhaps making them more susceptible to an eczematous reaction. It is unknown if this reaction may also occur with the Moderna mRNA COVID-19 vaccine. As more of the population is vaccinated against COVID-19, rare reactions are likely to surface and it is important to study these reactions to facilitate optimal management of patients who develop them. In this series of two patients who developed generalized eczematous reactions to the Pfizer-BioNTech COVID-19 vaccine, the reaction occurred with both doses, was managed by oral or systemic glucocorticoids and did not prevent safe administration of both doses of the vaccine.

Erythema multiforme after SARS-CoV-2 messenger RNA vaccination

“…Few cases associated with the COVID-19 vaccines have thus far been reported although underreporting may be partially responsible for the apparent paucity of cases, given the tremendous number of COVID-19 vaccinations that have been administered globally. 2–5 Cutaneous reactions due to COVID-19 mRNA vaccines in areas distant from the injection site have occurred in about 2% of vaccine recipients, but more importantly, 83% of individuals with a cutaneous reaction after the first vaccination may receive their second dose without a recurrence of the symptoms, as in the present case. 6 Clinicians should be aware of the diversity of cutaneous reactions due to COVID-19 mRNA vaccines and should inform and reassure patients with an initial skin reaction that they may safely receive their second vaccination.…”

Pfizer‐BioNTech SARS‐CoV‐2 mRNA vaccine‐associated erythema multiforme

“…To date, there have been three cases of EM related to the SARS-CoV-2 vaccine, two with the Moderna vaccine and another with Coronavac vaccine. 1,2 To the best of our knowledge, this is the first case of EM associated with the Pfizer-BioN-Tech Covid vaccine. EM is a self-limiting, cutaneous type IV hypersensitivity reaction.…”

“…Based on existing evidence, after administering the BNT162b2 (Pfizer) or AZD1222 (AstraZeneca) vaccines, more than 80% of participants developed injection site pain, while erythema and swelling were present in about 10%. 1,2 We report a series of adverse reactions consisting of early local reactions with atypical morphological appearance coinciding…”

Sever erythema multiforme post-COVID-19 moderna vaccine: Case report and literature review

“…However, Other causes have been identified, including various infectious organisms, medications, vaccines, and even internal illnesses. And recently has been linked to the COVID-19 vaccine [ 4 ].…”