Erythema Multiforme

Anderson, Nelson Paul

doi:10.1001/archderm.1945.01510190015002

Cited by 32 publications

(1 citation statement)

References 9 publications

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“…Urbach (1937) reported a further 20 cases, and described some experimental work supporting his hypothesis that an allergic mechanism is involved. Anderson (1945) reported 10 cases, and claimed satisfactory results from treatment by scarifying vaccination with smallpox vaccine four or five times at intervals of two weeks--a procedure previously found effective in some 80% of cases cf herpes simplex. Six of his cases of erythema multiforme were treated by this method ; four of these remained free from recurrences for from two to five years after one or two courses of vaccination, while another showed a reduction in the severity and frequency of attacks.…”

Section: Commentmentioning

confidence: 99%

Association of Erythema Multiforme with Herpes Simplex

Rook¹

1947

BMJ

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Section: Commentmentioning

confidence: 99%

Association of Erythema Multiforme with Herpes Simplex

Rook¹

1947

BMJ

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Lupus Erythematosus and Stevens-Johnson Syndrome

Rallison¹,

Carlisle²,

Lee³

et al. 1961

Am J Dis Child

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Erythema multiforme exudativum Stevens-Johnson syndrome) has been described in association with the administration of numerous medications, including sulfonamides,1-6 penicillin,7 thiouracil,5 phenylbutazone,8 salicylates, codeine,9 Fowler's solution,10 phenolphthalein,7 barbiturates,11,12 trimethadione,13 and diphenylhydantoin.14-16 A reversible, lupus-like disease, characterized by the L.E. cell phenomenon, with or without renal and systemic involvement, has also been attributed to medications such as hydralazine,17-22 penicillin,23,24 phenylbutazone,17 sulfadiazine,25,26 and methylphenylethylhydantoin (Mesantoin) .27It is the purpose of this paper to report the simultaneous occurrence of erythema multiforme exudativum and a reversible, lupus-erythematosus-like disease in 2 adoles-cent girls, as well as acute lupus erythematosus alone in a 4-year-old boy, following medication with anticonvulsant drugs. Report of CasesCase 1.\p=m-\Atthe age of 7\ m=1/ 2\years, this girl began experiencing petit mal seizures characterized by momentary lapses of consciousness, substantiated by typical 3-per-second spike and wave dis¬ charges on the electroencephalogram. She was given trimethadione (Tridione), 900 mg. daily, and phénobarbital, 45 mg. daily. Over the next 3Vi years, the seizures were controlled by variable amounts of these 2 medications.In 1954, at the age of 11 years, the patient de¬ veloped erythema multiforme exudativum (Stevens-Johnson syndrome), with scattered bullous skin lesions, mucous membrane vesiculation and ero¬ sion, conjunctivitis, fever, and malaise. Laboratory studies included a hemoglobin of 14 gm. '% ; a white blood count of 5,100, with 38% neutrophils, 53% lymphocytes, and 9% eosinophils; and an erythrocyte sedimentation rate of 10 mm/hour. Urinalysis was normal. Two L.E. clot tests were negative. The patient was treated with hydrogen peroxide soaks and 1% neomycin ointment applied to the more severe local lesions. Trimethadione and phénobarbital were discontinued, and the anti¬ convulsant medication changed to Mebroin (a synergistic combination of mephobarbital and diphenylhydantoin) 3 tablets daily, and paramethadione (Paradione), 300 mg. a day.Mild skin lesions recurred intermittently during the next 3 years. Then, in 1957, at age 14, the patient developed fever, cough, more extensive oral and genital lesions, and paronychia (Fig. 1).The lesions were identified as a recrudescence

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Diagnosis and Treatment of Misdiagnosed Dermatoses

Jillson¹

1958

JAMA

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Erythema Multiforme

Cited by 32 publications

References 9 publications

Association of Erythema Multiforme with Herpes Simplex

Association of Erythema Multiforme with Herpes Simplex

Lupus Erythematosus and Stevens-Johnson Syndrome

Diagnosis and Treatment of Misdiagnosed Dermatoses

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