Erythema elevatum et diutinum as a systemic disease

Sandhu, Jeena K.; Albrecht, Joerg; Agnihotri, Gaurav; Tsoukas, Maria M.

doi:10.1016/j.clindermatol.2019.07.028

Cited by 18 publications

(16 citation statements)

References 56 publications

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“…Direct immunofluorescence studies are not diagnostic and may show granular IgG and IgA deposits along the dermo-epidermal junction and IgG, IgM, C3, and fibrinogen deposits within vessels in the upper dermis. 3 Verrucous/pseudoepitheliomatous hyperplasia has been described in several inflammatory, infectious, and neoplastic conditions but not in vasculitides, and here it is assumed to result from the secretion of epidermal growth factor by dermal inflammatory cells. 4 In this patient, the composition of the inflammatory infiltrate, the patterned fibrosis, and the clinicopathologic correlation was the basis for the diagnosis.…”

Section: Discussionmentioning

confidence: 98%

Verrucous nodules on distal limbs

et al. 2021

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Section: Discussionmentioning

confidence: 98%

Verrucous nodules on distal limbs

et al. 2021

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“…The pathologic findings are correlated with the age of the lesion. The recurrent nature and chronicity of EED represent the most effective way to differentiate it from other types of cutaneous vasculitis [10].…”

Section: Discussionmentioning

confidence: 99%

“…Several autoimmune and inflammatory diseases may be associated with EED, including bacterial and viral infections, inflammatory bowel diseases, systemic lupus erythematosus, rheumatoid arthritis, myelodysplastic syndrome, hairy cell leukemia, Waldenstrom's macroglobulinemia, lymphoma, and solid malignancies [10]. Therefore, IgA gammopathy represents the most frequent disease associated with EED [11].…”

Section: Discussionmentioning

confidence: 99%

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

Alj¹,

Eljazouly²,

Chahboun³

et al. 2022

Cureus

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Neutrophilic dermatoses (ND) refer to a group of skin diseases characterized histologically by a cutaneous infiltrate of mature polymorphonuclear cells without an identifiable cause. Previously described as autonomous, these clinically distinct entities are included in the spectrum of neutrophilic disease due to the existence of overlapping forms, as described in our observation. Erythema elevatum diutinum (EED) is a rare dermatosis characterized by reddish-violaceous to browning papulonodular and plaques and belongs to the spectrum of cutaneous leukocytoclastic vasculitis. Chronic recurrent annular neutrophilic dermatosis (CRAND) is an exceptional neutrophilic dermatosis characterized by chronic annular lesions and the absence of generalized signs or hematological abnormalities. Histological features are similar to those seen in Sweet's syndrome.A 55-year-old woman with a history of pyoderma gangrenosum (PG) presented successively with two rare forms of ND, namely, EED and CRAND. There were no clinical or paraclinical arguments for any underlying systemic disease. Treatment with azathioprine 100 mg/day and topical steroids led to a total regression of lesions after a nine-month follow-up.Our observation is important because it reports two rare entities, CRAND and EED. Their occurrence in a single patient with a history of PG illustrates the concept of "neutrophilic disease" reported in the 1990s.

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“…EED is associated with monoclonal gammopathy, more frequently IgA MGUS [ 185 ] or multiple myeloma [ 189 , 190 ]. EED is also found with HIV infection [ 191 , 192 ], tuberculosis [ 193 ], hepatitis B infection [ 192 ], myelodysplastic syndrome [ 194 ], lymphoma [ 195 ], and autoimmune disease [ 190 ].…”

Section: Group IImentioning

confidence: 99%

“…Some patients with EED will have extracutaneous manifestations, including arthralgia, scleritis, panuveitis, ulcerative keratitis, neuropathy, and ulceration. On histopathology, early lesions demonstrate neutrophilic infiltration and typical leukocytoclastic vasculitis in the upper dermis to the mid-dermis [ 190 ]. With the progression of the disease, the papillary and periadnexal dermis become involved.…”

Section: Group IImentioning

confidence: 99%

Cutaneous manifestations of monoclonal gammopathy

2022

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Monoclonal gammopathy associated with dermatological manifestations are a well-recognized complication. These skin disorders can be associated with infiltration and proliferation of a malignant plasma cells or by a deposition of the monoclonal immunoglobulin in a nonmalignant monoclonal gammopathy. These disorders include POEMS syndrome, light chain amyloidosis, Schnitzler syndrome, scleromyxedema and TEMPI syndrome. This article provides a review of clinical manifestations, diagnostics criteria, natural evolution, pathogenesis, and treatment of these cutaneous manifestations.

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Erythema elevatum et diutinum as a systemic disease

Cited by 18 publications

References 56 publications

Verrucous nodules on distal limbs

Verrucous nodules on distal limbs

Associated Pyoderma Gangrenosum, Erythema Elevatum Diutinum, and Chronic Recurrent Annular Dermatosis: The Neutrophilic Disease Spectrum

Cutaneous manifestations of monoclonal gammopathy

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