Erythema Elevatum Diutinum Associated With IgA Paraproteinemia Successfully Controlled With Intermittent Plasma Exchange

Chow, R. K. P.; Benny, W. B.; Coupe, Robert; Dodd, W. Alan; Ongley, R. C.

doi:10.1001/archderm.1996.03890350102016

Cited by 40 publications

(25 citation statements)

References 28 publications

(2 reference statements)

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“…Many associations (infective, autoimmune and myeloproliferative) have been described. Of the myeloproliferative associations, paraproteinaemia is the best described 5 . Screening investigations in this case revealed an IgG K gammopathy of undetermined significance.…”

Section: Discussionmentioning

confidence: 78%

Tender erythematous papules on the elbows, buttocks and knees

Ryan

Hayes

Sheahan

et al. 2011

Clinical and Experimental Dermatology

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Section: Discussionmentioning

confidence: 78%

Tender erythematous papules on the elbows, buttocks and knees

Ryan

Hayes

Sheahan

et al. 2011

Clinical and Experimental Dermatology

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“…In patients with EED associated with HIV infection, adequate antiretroviral therapy in addition to conventional dapsone therapy was used successfully [38]. Chow et al used intermittent plasma exchange to successfully control a case of refractory EED associated with IgA paraproteinemia [5]. Hernandez-Cano et al reported the disappearance of EED lesions in a patient with a liver transplantation following a reduction in cyclosporin dosage [12].…”

Section: Discussionmentioning

confidence: 99%

“…Hernandez-Cano et al reported the disappearance of EED lesions in a patient with a liver transplantation following a reduction in cyclosporin dosage [12]. However, EED lesions may not respond to dapsone, or if they do, recurrences are quite common [5,11,24,31,39]. It is possible that the marked fibrosis in late lesions may account for the lack of response to dapsone [8].…”

Section: Discussionmentioning

confidence: 99%

Erythema elevatum diutinum and plastic surgery Case report

Lari¹,

George

Al-Saeed

2002

European Journal of Plastic Surgery

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Erythema elevatum diutinum (EED) is a chronic form of leucocytoclastic vasculitis that presents with symmetrical plaques, papules, and nodules in an acral distribution. The treatment is conservative, with dapsone being the first choice among the drugs commonly used. However, the late lesions may not respond due to the marked fibrosis, and they are extremely stressful to the patient both symptomatically and cosmetically. A case of EED in a patient with history of splenectomy for idiopathic thrombocytopenic purpura (ITP) is presented, where the late cutaneous lesions were excised and skin grafted. The association with splenectomy and the use of skin grafting as a mode of treatment when all other modalities have failed, have not been reported previously. A review of the relevant literature is presented.

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“…It characteristically involves the extensor surfaces of the knees, elbows, and hands. Rarely, systemic manifestations such as arthralgies are seen, as well as IgA paraproteinemia [25].…”

Section: Erythema Elevatum Diutinummentioning

confidence: 99%

Cutaneous vasculitis

Hayat¹,

Berney

2005

Curr Rheumatol Rep

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Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis occurs as a manifestation of many diseases including rheumatologic diseases, hypersensitivity syndromes, infections, and malignancies. The diagnosis of the cutaneous vasculitis and the underlying cause requires a complete history and physical exam and usually a biopsy or angiogram. The treatment depends on the etiology of the inflammation and includes immunosuppression, withdrawal of the offending agent, antibacterial/antiviral agents, and chemotherapies. A clear understanding and approach to this condition will improve the physician's ability to provide optimal patient care.

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Erythema Elevatum Diutinum Associated With IgA Paraproteinemia Successfully Controlled With Intermittent Plasma Exchange

Cited by 40 publications

References 28 publications

Tender erythematous papules on the elbows, buttocks and knees

Tender erythematous papules on the elbows, buttocks and knees

Erythema elevatum diutinum and plastic surgery Case report

Cutaneous vasculitis

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