Erythema elevatum diutinum-a report of two unusual patients

Statham, B. N.; Greenwood, Rachel; Tring, F.C.; Cotterill, J.A.

doi:10.1111/j.1365-2230.1983.tb01822.x

Cited by 20 publications

(12 citation statements)

References 4 publications

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“…In nodular lesions, dapsone is often ineffective due to the fibrosis of lesions . Sixteen patients were reported to have nodular lesions; these were described in patients with underlying HIV ( n = 4) and IgA gammopathies ( n = 4) . Eleven patients were noted to have an extra‐cutaneous manifestations associated with EED.…”

Section: Treatment Of Eedmentioning

confidence: 89%

“…Flare-ups of EED were noted when levels of IgA exceeded a threshold level. 44 On average, EED preceded the haematological diagnosis by 7.8 years. 1 Paraproteins can damage vessels by various mechanisms, including complement-mediated inflammatory processes.…”

Section: Immune-complex Associatedmentioning

confidence: 99%

“…Thirteen cases of EED in association with haematological disorders were studied and IgA clonal gammopathy was found to be the most commonly associated haematological disorder ( n = 4). Flare‐ups of EED were noted when levels of IgA exceeded a threshold level . On average, EED preceded the haematological diagnosis by 7.8 years .…”

Section: Eed and Associationsmentioning

confidence: 99%

“…Eleven cases were associated with haematological abnormalities (IgA paraproteinemia, Waldenstrom's macroglobulinemia and lymphoma) 1,4,14,18,[39][40][41][42][43][44] and two with solid malignancies. 45,46 Flare-ups of EED occurred in association with malignant lymphoma activity.…”

Section: Immune-complex Associatedmentioning

confidence: 99%

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Erythema elevatum diutinum: a review of presentation and treatment

Momen

Jorizzo

Al‐Niaimi

2014

Acad Dermatol Venereol

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Erythema elevatum diutinum (EED) is a rare, chronic and treatable skin condition. It has many histological mimics and is often associated with a variety of underlying systemic diseases, when these are present the management and prognosis dictates the course of the EED. This review aims to highlight the differential diagnosis, clinical manifestations of EED and the possible underlying systemic disease. It is important for clinicians to be aware that EED may predate underlying conditions and the presence of lesions may indicate underlying disease activity. In some cases one may need 'search' for underlying disease. Treatment of these lesions is notoriously difficult. Dapsone is used as the mainstay of treatment, however other options exist. We have highlighted different treatment options and suggested a treatment algorithm. In some cases, treatment may need to be targeted at underlying disease.

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Section: Treatment Of Eedmentioning

confidence: 89%

Section: Immune-complex Associatedmentioning

confidence: 99%

Section: Eed and Associationsmentioning

confidence: 99%

Section: Immune-complex Associatedmentioning

confidence: 99%

See 2 more Smart Citations

Erythema elevatum diutinum: a review of presentation and treatment

Momen

Jorizzo

Al‐Niaimi

2014

Acad Dermatol Venereol

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“…Neutrophilic dermatoses of the skin and mucosa that have been observed to occur in patients with cancer include erythema elevatum diutinum, [42][43][44][45][46] intraepidermal immunoglobulin A (IgA) pustulosis, 47,48 neutrophilic eccrine hidradenitis, 12 ALL, acute lymphocytic leukemia; AML, acute myelogenous leukemia; ATRA, alltrans retinoic acid; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia; CR, current report; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HIV, human immunodeficiency virus; IFN, interferon; IL, interleukin; NEH, neutrophilic eccrine hidradenitis; NSAID, nonsteroidal anti-inflammatory drug; SS, Sweet's syndrome; SSKI, saturated solution of potassium iodide; +, present; -, absent. *Ratios and percentages in parentheses refer to patients with malignancy-associated SS.…”

mentioning

confidence: 99%

Neutrophilic dermatoses occurring in oncology patients

Cohen¹

2007

Int J Dermatology

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Extensive Purpuric and Yellowish Papules and Plaques With an Annular Configuration

Perez¹

1991

Arch Dermatol

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A 63-year-old white woman was referred to the dermatology clinic of the University of South Florida College of Medicine, Tampa, for a chronic eruption mainly involving the extensor aspects of her arms and legs. Past treatment included corticosteroids, topically and systemically, with only modest improvement. The patient also complained of arthritis. Physical examination revealed widespread involvement, particularly of the extensor surfaces, with reddish-purple papules and plaques. Many of the lesions were grouped in an annular or circinate pattern (Fig 1). Close inspection disclosed two distinctive findings: lesions of recent onset by history were soft and purpuric (Fig 2), while those of greater duration were firm and yellowish (Fig 3). Large plaques were notable over bony prominences, especially the elbows, knees, and interphalangealjoints. All laboratory studies, including electrolytes, complete blood cell count with differential cell count, and erythrocyte sedimentation rate, were within normal ranges. A skin biopsy specimen was obtained that showed a dense, predominantly perivascular neutrophilic infiltrate with occasional eo¬ sinophils (Fig 4). Notable was fibrinoid necrosis and endothelial swelling of the small vessels (Fig 5). A zone of sparing (grenz zone) in the upper papillary dermis was also present (Fig 4). Dapsone therapy was begun after a test for the glucose-6-phosphate dehydrogenase level and a complete blood cell count showed normal results. Dramatic improvement was noted within 1 week. Over the next few months, attempts to discontinue the medication resulted in recrudescence.

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Erythema elevatum diutinum-a report of two unusual patients

Cited by 20 publications

References 4 publications

Erythema elevatum diutinum: a review of presentation and treatment

Erythema elevatum diutinum: a review of presentation and treatment

Neutrophilic dermatoses occurring in oncology patients

Extensive Purpuric and Yellowish Papules and Plaques With an Annular Configuration

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