1960
DOI: 10.1001/archderm.1960.01580040090016
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Erythema and Tumor Formation in Methoxsalen-Treated Mice Exposed to Fluorescent Light

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Cited by 50 publications
(4 citation statements)
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“…Evidence for the relationship is derived from clinical impressions and epidemiologic studies (Blum, 1959;Urbach et al, 1966;Urbach et al, 1973); direct confirmation of the carcinogenic potential of ultraviolet radiation (UV) comes from studies on laboratory animals (Roffo, 1934;Winkelmann et al, 1960;Epstein and Epstein, 1963;Epstein, 1970;Emmett, 1973). The production of tumors has routinely been observed after multiple UV exposures (Blum, 1959) or after one prolonged exposure (Hakim et al, 1960). The published evidence from both human and animal studies, in fact, indicates that neoplasia is a probable event only when the UV exposures extend over a significant fraction of the expected life span (Blum, 1959).…”
mentioning
confidence: 99%
“…Evidence for the relationship is derived from clinical impressions and epidemiologic studies (Blum, 1959;Urbach et al, 1966;Urbach et al, 1973); direct confirmation of the carcinogenic potential of ultraviolet radiation (UV) comes from studies on laboratory animals (Roffo, 1934;Winkelmann et al, 1960;Epstein and Epstein, 1963;Epstein, 1970;Emmett, 1973). The production of tumors has routinely been observed after multiple UV exposures (Blum, 1959) or after one prolonged exposure (Hakim et al, 1960). The published evidence from both human and animal studies, in fact, indicates that neoplasia is a probable event only when the UV exposures extend over a significant fraction of the expected life span (Blum, 1959).…”
mentioning
confidence: 99%
“…Cataracts have been reported by Cloud, Hakim & Griffin (1960) to occur in rodents who received large amounts of methoxsalen but did not occur in man or animals receiving lower therapeutic dosages (Freeman & Troll, 1959). Intraperitoneal methoxsalen injected into mice, plus exposure to UV~A has been shown to produce a high incidence of squamous cell carcinomas in albino mice (Hakim, Griffin & Knox, 1966). However, Griffin, Hakim & Knox (1958) reported orally administered psoralens UV-A did not show an increased risk of carcinogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Intraperitoneal administration of 8-MOP followed by irradiation with ultraviolet light also results in tumors on the skin of mice [95,98]. Oral administration of 8-MOP was less effective than intraperitoneal injection, with several reports noting little or no carcinogenic effect [95,[98][99][100][101], but the phototoxicity of orally adminitstered 8-MOP and 5-MOP, and direct chemical analyses [102], demonstrate that the compounds do reach the skin following ingestion. A recent epidemiological study [103] on humans exposed to therapeutic oral doses of 8-MOP and to ultraviolet radiation for the treatment of psoriasis has demonstrated a carcinogenic effect.…”
Section: Other Carcinogens In Foodsmentioning
confidence: 99%