Arch Dermatol
 1960
DOI: 10.1001/archderm.1960.01580040090016
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Erythema and Tumor Formation in Methoxsalen-Treated Mice Exposed to Fluorescent Light

R.E. Hakim1
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Cited by 55 publications

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“…Cataracts have been reported by Cloud, Hakim & Griffin (1960) to occur in rodents who received large amounts of methoxsalen but did not occur in man or animals receiving lower therapeutic dosages (Freeman & Troll, 1959). Intraperitoneal methoxsalen injected into mice, plus exposure to UV~A has been shown to produce a high incidence of squamous cell carcinomas in albino mice (Hakim, Griffin & Knox, 1966). However, Griffin, Hakim & Knox (1958) reported orally administered psoralens UV-A did not show an increased risk of carcinogenesis.…”
Section: Discussion
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Cataracts have been reported by Cloud, Hakim & Griffin (1960) to occur in rodents who received large amounts of methoxsalen but did not occur in man or animals receiving lower therapeutic dosages (Freeman & Troll, 1959). Intraperitoneal methoxsalen injected into mice, plus exposure to UV~A has been shown to produce a high incidence of squamous cell carcinomas in albino mice (Hakim, Griffin & Knox, 1966). However, Griffin, Hakim & Knox (1958) reported orally administered psoralens UV-A did not show an increased risk of carcinogenesis.…”
Section: Discussion
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The sam e type of m orpho logical changes in th e nucleolus observed by phase contrast microscope are reported in Chang liver cell treated by 4-nitroquinoline N-oxide [18] or actinom ycin [19]. I t is very interesting th a t these substances are strong carcinogenic agents and repeated trea tm e n t of 8MOP photosensitivity can induce carcinom a in mice [5]. In nucleolus rR N A is m ade by the action of tem plate DNA.…”
Section: Histologic Findings
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“……”
Section: Other Carcinogens In Foods
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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