Erythema and Tumor Formation in Methoxsalen-Treated Mice Exposed to Fluorescent Light

Hakim, R.E.; Griffin, A. Clark; Knox, John M.

doi:10.1001/archderm.1960.01580040090016

Cited by 50 publications

(4 citation statements)

References 4 publications

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“…Evidence for the relationship is derived from clinical impressions and epidemiologic studies (Blum, 1959;Urbach et al, 1966;Urbach et al, 1973); direct confirmation of the carcinogenic potential of ultraviolet radiation (UV) comes from studies on laboratory animals (Roffo, 1934;Winkelmann et al, 1960;Epstein and Epstein, 1963;Epstein, 1970;Emmett, 1973). The production of tumors has routinely been observed after multiple UV exposures (Blum, 1959) or after one prolonged exposure (Hakim et al, 1960). The published evidence from both human and animal studies, in fact, indicates that neoplasia is a probable event only when the UV exposures extend over a significant fraction of the expected life span (Blum, 1959).…”

mentioning

confidence: 99%

Induction of Skin Tumors in Hairless Mice by a Single Exposure to Uv Radiation*

Hsu

Forbes

Harber

et al. 1975

Photochem & Photobiology

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Skin tumors were induced in hairless mutant mice following a single exposure to ultraviolet radiation (UV). Tumors were first noted as early as 7 weeks following irradiation. The UV, emitted by FS20/40T12 fluorescent lamps, was principally in the 280-320 nm spectral region with a peak at 3 13 nm. Single (skin surface) doses of 3 x lo' J/m2 to 24 x lo' J/m2 were delivered in 3 h or less. The higher doses resulted in more severe acute damage as well as greater tumor yield.Most of the tumors were benign hyperplastic epithelial papillomas; 4 out of 96 tumors examined histologically proved to be squamous cell carcinomas. This appears to be the first report of experimental carcinogenesis due to a single UV exposure, not requiring exogenous chemical promotion.

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mentioning

confidence: 99%

Induction of Skin Tumors in Hairless Mice by a Single Exposure to Uv Radiation*

Hsu

Forbes

Harber

et al. 1975

Photochem & Photobiology

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“…Cataracts have been reported by Cloud, Hakim & Griffin (1960) to occur in rodents who received large amounts of methoxsalen but did not occur in man or animals receiving lower therapeutic dosages (Freeman & Troll, 1959). Intraperitoneal methoxsalen injected into mice, plus exposure to UV~A has been shown to produce a high incidence of squamous cell carcinomas in albino mice (Hakim, Griffin & Knox, 1966). However, Griffin, Hakim & Knox (1958) reported orally administered psoralens UV-A did not show an increased risk of carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Photochemotherapy for psoriasis remission times. Psoralens and UV-A and combined photochemotherapy with anthralin

Cripps

Lowe

1979

Clinical and Experimental Dermatology

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Summary Oral methoxsalen and long‐wave ultraviolet light (PUVA) was evaluated in 187 psoriatics, with emphasis on remission and recurrence after therapy. The mean number of years psoriasis had been present was 18.3, the mean psoriatic involvement 34.8% the dose at the time of maximum clearance was 11.8 J/cm2, and the mean number of treatments to achieve maximum clearance was 175. Complete clearance was achieved in sixty‐one patients and in this group the average number of treatments to achieve maximum clearance was 16.8, the initial remission times ranged from 4 to 64 weeks, with an average of 21.6 weeks. In patients subsequently retreated, the remission time was only 12.4 weeks (57%), but the mean number of treatments to achieve maximum clearance was reduced (11.4) and patients responded more easily to treatment. Sixteen patients were treated in addition to PUVA, with anthralin in Lassars' paste with clearing achieved between six and fifteen treatments, a mean of 9.5. Combinations of PUVA with other forms of psoriatic treatment may also help to reduce the cumulative PUVA exposures.

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“…Intraperitoneal administration of 8-MOP followed by irradiation with ultraviolet light also results in tumors on the skin of mice [95,98]. Oral administration of 8-MOP was less effective than intraperitoneal injection, with several reports noting little or no carcinogenic effect [95,[98][99][100][101], but the phototoxicity of orally adminitstered 8-MOP and 5-MOP, and direct chemical analyses [102], demonstrate that the compounds do reach the skin following ingestion. A recent epidemiological study [103] on humans exposed to therapeutic oral doses of 8-MOP and to ultraviolet radiation for the treatment of psoriasis has demonstrated a carcinogenic effect.…”

Section: Other Carcinogens In Foodsmentioning

confidence: 99%

Carcinogens and mutagens present as natural components of food or induced by cooking

1985

Nutrition and Cancer

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Erythema and Tumor Formation in Methoxsalen-Treated Mice Exposed to Fluorescent Light

Cited by 50 publications

References 4 publications

Induction of Skin Tumors in Hairless Mice by a Single Exposure to Uv Radiation*

Induction of Skin Tumors in Hairless Mice by a Single Exposure to Uv Radiation*

Photochemotherapy for psoriasis remission times. Psoralens and UV-A and combined photochemotherapy with anthralin

Carcinogens and mutagens present as natural components of food or induced by cooking

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