Eruptive xanthoma

Abdelghany, Mahmoud; Massoud, Samuel

doi:10.3949/ccjm.82a.14081

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…Nicotinic acid, omega-3 fatty acids, and bile acid sequestrants are also effective as well. The clinical signs of hypertriglyceridemia, eruptive xanthoma typically resolved with treatment [7,8].…”

Section: Discussionmentioning

confidence: 99%

Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus

Lee

Sheth

2019

Journal of Community Hospital Internal Medicine Perspectives

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Eruptive xanthoma is characterized by yellowish skin papules encircled by an erythematous halo and associated with severe hypertriglyceridemia above 2,000 mg/dl. Hypertriglyceridemia can be caused by primary genetic mutations, secondary causes, such as uncontrolled diabetes, obesity, alcohol overuse, or combinations of both. Eruptive xanthoma can serve as an important clinical indicator of underlying systemic conditions (e.g. hypertriglyceridemia and uncontrolled diabetes mellitus). It is important for clinicians to recognize it to prevent further complications such as pancreatitis and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus

Lee

Sheth

2019

Journal of Community Hospital Internal Medicine Perspectives

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“…Ketosis-prone diabetes is on occasion accompanied by hypertriglyceridemia [12][13][14]. There are several case reports documenting eruptive xanthomas with severe hypertriglyceridemia (>2,000 mg/dL) as well as uncontrolled diabetes mellitus (HbA1c >10%) [3,[15][16][17][18][19]. Most of these patients were relatively young (<40-year-old) and were obese (BMI >25 kg/m 2 ).…”

Section: Discussionmentioning

confidence: 99%

Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2

et al. 2019

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Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes. We herein report a 15-year-old obese patient with the apolipoprotein E4/2 phenotype, in whom eruptive xanthomas lead to a diagnosis of soft-drink diabetic ketosis. He developed multiple asymptomatic yellowish papules on the auricles, back, buttocks and the extensor surfaces of the elbows and knees. He initially visited a dermatology clinic and his blood triglyceride and HbA1c levels were found to be 6,490 mg/dL and 16.5%, respectively. He was referred to our hospital for treatment of hyperglycemia and hypertyriglyceridemia. On admission, he had ketonuria and increased blood levels of 3-hydroxybutylate and acetoacetate. He habitually drank 1-3 litters of sweet beverages daily to quench his thirst. Therefore, "soft-drink diabetic ketosis" was diagnosed. Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype. We treated the diabetic ketosis and hypertriglyceridemia with intensive insulin therapy and a fat-restricted diet. At discharge, he no longer required insulin therapy and his blood glucose levels were controlled with metformin and voglibose. Along with amelioration of the hyperglycemia, triglyceride levels decreased to 247 mg/dL without administration of anti-hyperlipidemia agents. The eruptive xanthoma lesions gradually diminished in size and number and eventually disappeared by 12 months. This case provides an instructive example of eruptive xanthomas serving as a sign of severe dysregulation, not only of lipid, but also glucose, metabolism.

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“…[2] The disease is a characteristic manifestation of extreme hypertriglyceridemia. [3] Exact epidemiological data on the prevalence of various types of xanthoma are lacking, eruptive xanthomas are retrospectively reported in 10% of patients with severe hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of eruptive xanthoma

Kashif

Kumar²,

Khaja³

2016

Medicine

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Background:Eruptive xanthomas are benign skin lesions caused by localized deposition of lipids in the dermis. The lesions are generally caused by elevated levels of serum triglycerides that leak through the capillaries and are phagocytosed by macrophages in the dermis. Clinical manifestation varies from asymptomatic skin lesions to intense pruritus and tenderness.Methods:We present a case of a middle-aged man admitted with diabetic ketoacidosis secondary to noncompliance with insulin. He was found to have skin lesions as multiple crusted papules on the extremities. Further evaluation revealed elevated serum triglycerides. A diagnosis of eruptive xanthomas was made on skin biopsy, and after starting treatment with lipid lowering agents his cutaneous lesions gradually subsided.Conclusion:Appearance of eruptive xanthomas can signify the onset of serious complications. Prompt recognition of such skin manifestations is warranted to prevent development of fatal medical condition like coronary artery disease and pancreatitis.

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Eruptive xanthoma

Cited by 9 publications

References 7 publications

Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus

Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus

Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2

An unusual presentation of eruptive xanthoma

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