Eruptive vellus hair cysts with sebaceous glands

Abstract

A patient is described who had eruptive vellus hair cysts with and without sebaceous glands in the cyst walls. An association is suggested between eruptive vellus hair cysts and the condition of steatocystoma multiplex.

Eruptive Vellus Hair Cysts: Report of a New Case with Immunohistochemical Study and Literature Review

“…Occasionally, fragmented vellus hair shafts may be seen within the cyst. However, cases with overlapping pathological features between SCM and EVHC exist [7] and are often referred to as ‘hybrid cysts’ [11]; in addition, some patients reportedly have lesions of both SCM and EVHC [12]. It has therefore been proposed that EVHC and SCM are variants of one disorder originating in the pilosebaceous duct [9].…”

“…Whereas most clinical simulators of EVHC can be differentiated histologically, the distinction from SCM may be delicate. The relationship between the two conditions has been debated as they share similarities regarding age of onset, localization, clinical appearance and mode of inheritance [2], so that some authors regard them as variants of one entity [7]. However, typical EVHC and SCM usually display different clinicopathological and immunohistochemical features [10].…”

“…The expression of Ki67 was reduced, suggesting that the proliferation rate of the lesions is low, at least within a clinically stable lesion. Sebaceous glands have been rarely found within or near the cyst wall [7], raising the problem of differential diagnosis with steatocystomas (see below). In our case the cyst was not associated with sebaceous glands, as was also confirmed by the non-expression of sebocyte-associated antigens, including epithelial membrane antigen and androgen receptors (although these were expressed by normal sebaceous glands present in the surrounding dermis).…”

“…Facial lesions occur [4]; they were the unique localization in ten cases [2] and were unilateral in one of them [5]. Unusual sites include the back, labium major [6], the buttocks and groin [7]. The lesions are usually flesh-colored, but may be brown, red, white, bluish-grey (especially in Asian people) or yellowish [2,6] and may have an umbilicated or crusted surface [2].…”

Cutaneous Neoplasms with Sebaceous Differentiation

“…39 This entity shares a close histologic relationship with eruptive vellus hair cysts. [40][41][42][43] Gross: Yellow to tan papules or cysts with a smooth surface. The lesion has a predilection for the chest and the extensor surfaces of the proximal extremities but can be found in the axilla, groin, scrotum and less frequently on other epidermal surfaces.…”