Eruptive pseudoangiomatosis in adults with immune system disorders: A report of two cases

Saldana, Sandra; Flores, Raul G. Mendez; Gutiérrez, Andrea F. López; Núñez, Lupita N. Salas; Loya, Ana Karen Hermosillo; Padilla, Marisol Ramírez; Torres, Mercedes Hernández

doi:10.4081/dr.2020.8836

Cited by 2 publications

(4 citation statements)

References 8 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the most affected patients were in the first decade of life, followed by those in the second decade. Thus, the disease usually affects those in the lower spectrum of life, as described by González et al [6] and others [7,8]. This may potentiate the viral etiology in the pathogenesis of the disease because children and young age groups are more susceptible to viral infections because their immunity remains not built well enough against these particles.…”

Section: Discussionmentioning

confidence: 98%

“…The diagnosis of EPA mainly depends on its characteristic clinical features. Histopathological examination is not pathognomonic yet may exclude other diseases resembling it [6]. The histopathological features consist of dermal blood vessel dilatation with plump endothelial lining with perivascular infiltration of lymphocytes [22].…”

Section: Discussionmentioning

confidence: 99%

“…The illness resembles a common disease that occurs in Japan caused by an insect bite [5]. It appears that mosquito bites, flea bites and bites by other arthropods, viral infections, an enhanced insect bite reaction, immunocompromised diseases, and drugs are the possible pathogenic causes of the disease [6]. Herein, we report forty-five patients with this condition and attempt to explore their epidemiological and clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Eruptive pseudoangiomatosis: An epidemiological and clinical study

Mancy¹,

Awad²,

Hafedh³

2023

Our Dermatol Online

View full text Add to dashboard Cite

Background: Eruptive pseudoangiomatosis is an acute-onset illness presenting with a characteristic rash mainly on the exposed parts of the body. It is mostly symptomless and resolves spontaneously without sequels. Numerous agents are suspected to trigger the disease. Materials and Methods: Forty-five patients affected with eruptive pseudoangiomatosis were examined at the Dermatology and Venereology Department of Al-Ramadi Teaching Hospital during the period from January 1, 2018, to January 1, 2020. History taking and physical examination in addition to laboratory investigations were done for all patients. Results: Forty-five patients, 27 females and 18 males, were examined. Their mean age was fifteen years and the female-to-male ratio was 1.5:1. The younger age group was the most involved and a family history was detected in 5%. Prodromal symptoms were found in 63.8% and pruritus was a complaint in 35.5% of the patients. The extremities and face were the most affected and the disease was more common during the spring season. Conclusion: Eruptive pseudoangiomatosis is a spontaneously-resolving illness without complications, yet one must be aware of it and keep it in mind when facing a viral rash to avoid unnecessary investigations and treatments and to provide reassurance to the patient and their family. Key words: angioma; pseudoangioma; viral infection; pruritus; URTI

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eruptive pseudoangiomatosis: An epidemiological and clinical study

Mancy¹,

Awad²,

Hafedh³

2023

Our Dermatol Online

View full text Add to dashboard Cite

show abstract

“…In adults, it is strongly associated with immunosuppressed states; such as kidney transplantation, haematological malignancies and elderly patients. 4 Haematogenous dissemination of the causative virus following inoculation leads to prodromal symptoms followed by an exanthem in children, while re‐infection under immunosuppressed conditions probably results in proliferation of the causative agent in adults. 1 The rash is mostly asymptomatic or may be associated with mild pruritus.…”

Section: Figurementioning

confidence: 99%

Development of eruptive pseudoangiomatosis following immunization with COVISHIELD vaccine in an adult

Prarthana

Bakshi

Hanumanthu

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

skin. The cause was subsequently found to be iatrogenicpolymixin B was prescribed to both patients to treat multidrug resistant bacterial infection. 2 The localized hyperpigmentation involving the centrofacial area that we observed in our patients was reminiscent of the 'Chik sign'. 3 In resource-limited settings, this classic pigmentary sequelae serves a cutaneous clue in making a retrospective diagnosis of chikungunya fever and rarely dengue. 4,5 The underlying pathology remains speculative. On histopathology, increased basal layer pigmentation, pigmentary incontinence and dermal melanophages with perivascular inflammatory infiltration have been observed. Thus, an increased intraepidermal melanin dispersion/retention triggered by the virus has been postulated as a cause for pigmentation. 6 Predominant affection of the centrofacial area indicates the possible role of ultraviolet radiation exposure in this patterned distribution of pigmentation. As a postviral event, this mechanistic reasoning may explain the pigmentary outcome in SARS-CoV-2-infected patients. Interestingly, accompanying postfebrile arthritis is a feature common to both the viral aetiologies (SARS-CoV-2 and chikungunya). 7 Thus, making a serological diagnosis is imperative in such cases. After excluding the common causes and given the temporal relation with COVID-19, the cause of the nasal pigmentation in these patients was attributed to SARS-CoV-2 infection.Hyperpigmentation associated with chikungunya fever (CF) usually develop after 1-3 weeks after fever defervescence. 6,8 In our set of patients, a slightly longer time gap was noted. Therapeutic measures like photo-protection, sunscreen and topical usage of hypopigmenting agents of hydroquinone cream with or without short course topical steroids for a month have shown good response in treating hyperpigmentation in CF patients. 4,9 For our patients, we had to continue topical therapy for nearly 3-4 months for clinical improvement to be appreciable.In conclusion, we highlight here a unique series of patients where a pigmentary sequelae ('COVID nose') was directly ascribed to COVID-19. 'Chik sign', which is considered a feature quite unique to CF, should also raise the suspicion of a preceding COVID-19 infection. We further implore clinicians to broaden the list of differentials for this presentation to include other viral aetiologies.

show abstract

Eruptive pseudoangiomatosis in adults with immune system disorders: A report of two cases

Cited by 2 publications

References 8 publications

Eruptive pseudoangiomatosis: An epidemiological and clinical study

Eruptive pseudoangiomatosis: An epidemiological and clinical study

Development of eruptive pseudoangiomatosis following immunization with COVISHIELD vaccine in an adult

Contact Info

Product

Resources

About