Eruptive nevi associated with medications (ENAMs)

Perry, Benjamin M.; Nguyen, Anne; Desmond, Bryce; Blattner, Collin M.; Thomas, Rosalyn; Young, Rosemarie

doi:10.1016/j.jaad.2016.04.064

Cited by 30 publications

(40 citation statements)

References 111 publications

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“…Relationship with various pharmacologic treatments (i.e. azathioprine, corticosteroids, combination chemotherapy) has already been described (11). Recently, the common use of biologics has become another possible cause of eruptive naevi (10,11).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Agminated Spitzoid Naevi after Remission of Langerhans Cell Histiocytosis: First Italian Case and Literature Review

Rotunno

Diociaiuti²,

Vito³

et al. 2019

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 98%

“…azathioprine, corticosteroids, combination chemotherapy) has already been described (11). Recently, the common use of biologics has become another possible cause of eruptive naevi (10,11). According to some reports on LCH and agminated naevi, chemotherapy might play a role, but was not administered in one of the reported patients.…”

Section: Discussionmentioning

confidence: 99%

Agminated Spitzoid Naevi after Remission of Langerhans Cell Histiocytosis: First Italian Case and Literature Review

Rotunno

Diociaiuti²,

Vito³

et al. 2019

Acta Derm Venerol

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“…EMN is the sudden occurrence of multiple melanocytic nevi within weeks or months. It may develop in relation to dermatological diseases, such as Stevens‐Johnson syndrome and bullous disease, systemic diseases, such as renal transplantation and malignancy, or in response to certain medications; the latter is a rare phenomenon 1 . EMN cases induced by many different medications have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…EMN cases induced by many different medications have been reported. As discussed above, drug‐induced EMN may be classified as immunosuppressant, chemotherapeutic, and direct melanocyte stimulators 1 …”

Section: Discussionmentioning

confidence: 99%

Eruptive melanocytic nevi during etanercept treatment in an ankylosing spondylitis patient: Case report

Erdem

Altunay

Özkur

2020

Dermatologic Therapy

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Eruptive melanocytic nevi (EMN) are rare multiple melanocytic lesions that rare and associated with dermatological and systemic diseases. Drug induced EMN is also reported with the use of biological or nonbiological chemotherapeutics, immunosuppressive agents, and melanocyte stimulators. In recent years, the increasing use of biological drugs resulted in an increased reports of EMN induced by these drugs. The objective of this abstract is reporting EMN in a patient receiving etanercept treatment. In addition, we also present a literature review of the previously cases with anti‐tumor necrosis factor‐α biological agents.

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“…Dari literatur diketahui terdapat beberapa obat yang dapat menyebabkan drug-induced eruptif nevi melanositik misalnya obat imunosupresif non-biologik (siklosporin, metotreksat, azatioprin, obat biologik yang menargetkan tumor necrosis factor, imunosupresif biologik (etanercept, alefacept, infliximab, rituximab), kemoterapi dan stimulator melanosit. 8 Pada kasus ini ibu pasien mendapatkan terapi metilprednisolon selama kehamilan, tetapi belum diketahui apakah pemakaian kortikosteroid dapat menginduksi CMN. Sepanjang pengetahuan penulis, kasus ini merupakan kasus pertama yang melaporkan seorang bayi GCMN, lahir dari ibu dengan SLE dan mendapatkan terapi metilprednisolon.…”

Section: Diskusiunclassified

Giant Congenital Melanocytic Nevus: Laporan Kasus Langka

Fitriani¹,

Ayu²,

Aryani³

et al. 2019

MDVI

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ABSTRAKGiant congenital melanocytic nevus (GCMN) merupakan penyakit langka yang timbul saat lahir akibat sel melanosit tumbuh berlebih. Lesi pada GCMN sering ditemukan pada area punggung dan paha. Gambaran lesi berupa bercak hiperpigmentasi dengan ukuran lebih dari 20 cm dan terdapat rambut. Kondisi ini sering dihubungkan dengan neurokutaneus melanositosis dan melanoma maligna. Risiko neurokutaneus melanositosis meningkat signifikans bila lesi giant nevi terdapat pada regio kranial atau garis midline atau disertai lesi satelit. Rerata kumulatif risiko terjadinya melanoma dalam 5 tahun sebesar 4,5%. Pendekatan terapi masih menjadi tantangan dan bersifat individual bergantung pada usia, lokasi lesi, ukuran, risiko melanoma dan kemungkinan kelainan fungsi akibat tindakan invasif yang dilakukan serta dampak fisiologis terhadap luka pasca tindakan. Dilaporkan bayi perempuan usia 2 hari, lahir pervaginam, cukup bulan dari seorang ibu P4A0 menderita SLE yang diterapi metilprednisolon selama kehamilan. Status generalis dalam batas normal. Status dermatologikus pada regio skalp, fasialis, trunkus, ekstremitas superior dan inferior bilateral tampak makula-plak hiperpigmentasi, multipel, bulat-irregular, lentikuler-plakat, diskret; sebagian terdapat rambut, kulit sekitar normal; terdapat lesi satelit. Pada regio ekstremitas inferior sinistra terdapat lesi giant nevi dengan ukuran lebih dari 20 cm. Pada kasus ini diperlukan observasi yang baik dan pendekatan multidisiplin dalam tatalaksana GCMN. ABSTRACT Giant congenital melanocytic nevus (GCMN) is a rare disease caused by excessive growth of melanocytes. It appeared since birth. This disease often found on the back and thigh. Lesion of GCNM often appear as a solitary or multiple well defined hyperpigmented hairy plaque measuring 20 cm or larger. This condition is frequently associated with neurocutaneous melanocytosis and malignant melanoma. The risk of neurocutaneous melanocytosis significantly increases if giant nevus lesion located on cranial or midline region or accompanied by satellite lesions. Cumulative 5-year risk for the growth of melanoma is 4,5%.Therapeutic approach is still a challenge and varies among each individual according to age, location, size of lesion, risk of melanoma and possibility of function abnormalities from invasive treatment and physiological impact due to post treatment effect. We reported a case of two-days-old full term female, born naturally and full term with GCMN. The mother suffered systemic lupus erythematosus and received methylprednisolone during pregnancy. General appearance was unremarkable. Dermatological physical examination present with a multiple well defined round -irregular hyperpigmented macules and plaques, some area were covered with hair and some surrounded with satellite papules on the truncus, scalp, facialis, extremities superior et inferior bilateral region. There is giant nevi lesion with size > 20 cm on the left lower extremity. Close observation dan multidiscipline approach is needed for management of GCMN in our ca...

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Eruptive nevi associated with medications (ENAMs)

Cited by 30 publications

References 111 publications

Agminated Spitzoid Naevi after Remission of Langerhans Cell Histiocytosis: First Italian Case and Literature Review

Agminated Spitzoid Naevi after Remission of Langerhans Cell Histiocytosis: First Italian Case and Literature Review

Eruptive melanocytic nevi during etanercept treatment in an ankylosing spondylitis patient: Case report

Giant Congenital Melanocytic Nevus: Laporan Kasus Langka

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