Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma

Smith, Steven P.; Konnikov, Nellie

doi:10.1016/0190-9622(91)70289-e

Cited by 15 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The appearance of follicular hyperkeratoses and cysts has, so far, only been reported in overt cases of MF. [2][3][4][5] The patient presented here clearly demonstrated that this can also be seen in pre-MF, as we suggested previously. 6 The prolonged history of skin involvement might be relevant for the development of central nervous system (CNS) involvement.…”

Section: Follicular Cysts and Hyperkeratoses As First Manifestation supporting

confidence: 81%

Follicular cysts and hyperkeratoses as first manifestation, and involvement of the central nervous system as late manifestation of mycosis fungoides

Kerkhof¹,

Rossum²,

Hengstman³

et al. 2005

Acad Dermatol Venereol

View full text Add to dashboard Cite

Section: Follicular Cysts and Hyperkeratoses As First Manifestation supporting

confidence: 81%

Follicular cysts and hyperkeratoses as first manifestation, and involvement of the central nervous system as late manifestation of mycosis fungoides

Kerkhof¹,

Rossum²,

Hengstman³

et al. 2005

Acad Dermatol Venereol

View full text Add to dashboard Cite

“…12,13 This might explain non-in¯ammatory cysts which have been reported in patients with MF, 11±13,31 but not the preferential homing of T lymphocytes in the follicular epithelium. The possibility that previous topical therapies such as nitrogen mustard or PUVA could induce abnormal keratinization of the infundibulum and lead to comedo formation 11,31 does not seem likely, as in most of our cases and those previously reported the follicular lesions had been present before therapy was instituted.…”

Section: Discussionmentioning

confidence: 49%

Follicular cutaneous T-cell lymphoma: a clinicopathological study of nine cases

Hodak

Feinmesser

Segal

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

Nine patients with follicular cutaneous T-cell lymphoma (CTCL), a recently described variant of lymphoma, are presented. On the basis of clinical manifestations and disease course, three groups of patients were distinguished: (i) two patients with follicular CTCL not associated with conventional lesions of mycosis fungoides (MF) and showing no evolution towards MF in follow-up periods of 3 and 6 years; (ii) one patient with follicular CTCL that evolved into conventional MF within 3 years; (iii) six patients showing conventional MF lesions either before or concurrently with the follicular lesions and thus representing follicular CTCL of the true MF type. The follicular lesions included hair-devoid patches or plaques with spiky hyperkeratotic papules (four patients), keratosis pilaris-like lesions (four), comedo-like lesions (four), follicular papules with alopecia (three) and milia-like lesions (three). Histopathological examination showed perifollicular and intrafollicular lymphocytes, without mucin deposition and with minimal or no involvement of the overlying epidermis. Significant syringotropism was also observed in three cases. Immunohistochemical analysis showed the predominance of CD4 + T cells, deletion of CD7 in some cases, Ki-67 + lymphocytes confined mainly to the follicular epithelium, and expression of keratinocyte intercellular adhesion molecule-1 exclusively in the hair follicle. T-cell receptor gamma gene rearrangement was positive in the one case studied from each group. Different treatment modalities were employed, the most commonly used as monotherapy being phototherapy: psoralen ultraviolet A in four patients, two of whom showed a complete clinical and histopathological remission, and ultraviolet B in one patient, who showed a complete remission (both clinical and histopathological). This study indicates that follicular CTCL is more common than reflected in the literature, has heterogeneous clinical manifestations, and is either an expression of or closely related to MF. The influence of the follicular involvement on the therapeutic response remains to be clarified. However, our therapeutic experience clearly suggests that some patients with follicular CTCL can benefit from phototherapy.

show abstract

“…Additional cutaneous therapy was defined as skin-directed treatment given for at least 8 Twenty-four patients, or 21%, developed a BCC or an SCC (95% confidence interval, 13.5% to 28.5%) dur¬ ing a period ranging from 11 months to more than 10 years after TSEBT. Fourteen men and 10 women, rang¬ ing in age from 36 to 76 years at the time of TSEBT, de¬ veloped more than 37 BCCs and 34 SCCs.…”

mentioning

confidence: 99%

Malignant Melanoma and Other Second Cutaneous Malignancies in Cutaneous T-Cell Lymphoma

Licata

Wilson²,

Braverman³

et al. 1995

Arch Dermatol

View full text Add to dashboard Cite

Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma

Cited by 15 publications

References 26 publications

Follicular cysts and hyperkeratoses as first manifestation, and involvement of the central nervous system as late manifestation of mycosis fungoides

Follicular cysts and hyperkeratoses as first manifestation, and involvement of the central nervous system as late manifestation of mycosis fungoides

Follicular cutaneous T-cell lymphoma: a clinicopathological study of nine cases

Malignant Melanoma and Other Second Cutaneous Malignancies in Cutaneous T-Cell Lymphoma

Contact Info

Product

Resources

About