Éruption bulleuse à l’huile de nigelle

Gelot, P.; Bara-Passot, C.; Giménez‐Arnau, Elena; Bénéton, N.; Maillard, H.; Célérier, P.

doi:10.1016/j.annder.2012.01.025

Cited by 18 publications

(2 citation statements)

References 13 publications

(15 reference statements)

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“…Ibraheim also reported that only the total oil showed significant increases in the AST and the ALT levels while both the oil and the crushed seeds showed significant increases in the γ -GT and the alkaline phosphatase (ALP) activities [51]. A case of systemic and contact bullous drug eruption as erythematous plaques with vesicles and bullous lesions because of topical application and digestion of NS oil was reported [52]. In addition, another report showed that the use of NS at 5 g/day inhibited CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in healthy human volunteers, showing that it may interact with other CYP2D6 and CYP3A4 substrates [53].…”

Section: Resultsmentioning

confidence: 99%

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Mahdian²,

et al. 2017

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ObjectivesNigella sativa (black seed or black cumin), which belongs to the Ranunculacea family, is an annual herb with many pharmacological properties. Among its many active constituents, thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa (N. sativa) seeds, and it is the constituent to which most properties of this herb are attributed.MethodsPubMed-Medline, Scopus, and Web of Science databases were searched to identify randomized control trials (RCTs) investigating the therapeutic effects of N. sativa and/or TQ. In this review, we investigated the clinical uses of N. sativa and TQ in the prevention and the treatment of different diseases and morbidity conditions in humans.ResultsBlack seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome. Also, other advantages, including antimicrobial, anti-nociceptive and anti-epileptic properties, have been documented. The side effects of this herbal medicine appear not to be serious, so it can be applied in clinical trials because of its many advantages.ConclusionSome effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments. However, most of its other effects and applications require further clinical and animal studies.

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Section: Resultsmentioning

confidence: 99%

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Mahdian²,

et al. 2017

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“…This limits the use of commercially available impure extracts and oils of N. sativa as a wound healing agent. In addition, it has been reported that N. sativa extract and oil cause irritation or allergic problems (18,19). Therefore, research should focus on active components of N. sativa.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vitro Wound Healing Activity of Thymoquinone

Pekmez¹,

Milat²

2020

Eur J Biol

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Objective: Nigella sativa has been extensively investigated as an important potential agent for the healing of wounds and there have been numerous studies regarding its effect. Although thymoquinone (TQ) is a well-known active constituent of Nigella sativa, studies in to the usability of TQ on wound healing are still insufficient. In this study, we aimed to evaluate the in vitro wound healing potential of TQ.Materials and Methods: NIH/3T3 mouse embryonic fibroblast cells were used to evaluate the wound healing effect of TQ. Different concentrations of TQ (0.1, 1 and 10 µM) were applied to the cells and their cytotoxic effect on cells after 24-and 48-hours was measured by MTT assay. Its effect on wound healing after 18-and 24-hours recovery was examined by in vitro scratch assay. Also, the level of β-catenin, an effective protein in the process of healing wounds, was determined by Western blot assay.Results: MTT analysis indicated that 0.1, 1 and 10 µM doses of TQ had increased the cell numbers. In vitro scratch assay data showed that treatment with 1 and 10 µM TQ resulted in a statistically significant wound closure activity (91.35% and 90.84%, respectively) compared to the control. Additionally, we observed a statistically significant increase in the β-catenin protein level which supported our data. Conclusion:Our results demonstrated that TQ increases both the viability of NIH/3T3 cells and its wound closure activity in vitro, and that it has the effect of increasing crucial protein β-catenin. This study suggests that TQ may be a valuable substance for the healing of wounds and that its usability should be investigated.

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Nigella sativa L. (Ranunculaceae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Éruption bulleuse à l’huile de nigelle

Cited by 18 publications

References 13 publications

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Evaluation of In Vitro Wound Healing Activity of Thymoquinone

Nigella sativa L. (Ranunculaceae)

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