Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-κB and p38 MAPK pathway

Liang, Xiaoli; Huang, Yuan; Pan, Xiping; Hao, Yanbing; Chen, Xiaowei; Jiang, Haiming; Li, Jing; Zhou, Beixian; Yang, Zifeng

doi:10.1016/j.jpha.2019.09.005

Cited by 49 publications

(49 citation statements)

References 73 publications

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“…Gene ratio refers to the ratio of enriched genes to all target genes, and counts refer to the number of the enriched genes NF-κB and p38 MAPK pathway, indicating a therapeutic potential for T-cell apoptosis tendency triggered by SARS-CoV-2. [36][37][38] Guanghuoxiang, also named pogostemon cablin, is a well-known Chinese materia medica. Kiyohara et al exhibited a 99.8% inhibitory effect against the H1N1 influenza virus at a concentration of 10 μg/mL methanol extract from Guanghuoxiang.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19

et al. 2020

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“…PARP-1 activation has been regarded as one of the critic mechanisms underlying lung inflammation in the context of lipopolysaccharide (LPS) and elastase stimulations experimentally [8,9]. Evidences indicated the abnormal increased expression of PARP-1 in non-pulmonary cells, alveolar epithelial cells, and lung tissue after IAV infection [10,11], suggesting its potential as the target for the treatment of IAV infection. One of the PARP inhibitors, olaparib, is reported to ameliorate acute lung injury induced by elastase and LPS [9,12].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice

Liu

Ren

Wang

et al. 2020

Eur J Clin Microbiol Infect Dis

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Treatments against influenza A viruses (IAV) have to be updated regularly due to antigenic drift and drug resistance. Poly (ADPribose) polymerases (PARPs) are considered effective therapeutic targets of acute lung inflammatory injury. This study aimed to explore the effects of PARP-1 inhibitor olaparib on IAV-induced lung injury and the underlying mechanisms. Male wild-type C57BL/6 mice were intranasally infected with IAV strain H1N1 to mimic pneumonia experimentally. Olaparib at different doses was intraperitoneally injected 2 days before and 5 consecutive days after virus stimulation. On day 6 post-infection, lung tissues as well as bronchoalveolar lavage fluid (BALF) were sampled for histological and biochemical analyses. Olaparib increased the survival rate of IAV mice dose-dependently. Olaparib remarkably reduced IAV mRNA expression, myeloperoxidase (MPO) level, and inflammatory cell infiltration in IAV lungs. Moreover, olaparib significantly reduced the level of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, and IL-4 and increased IL-10 in IAV lungs. Also, olaparib efficiently reduced IL-6, monocyte chemotactic protein (MCP)-1, granulocyte colony-stimulating factor (G-CSF), TNF-α, chemokine (C-X-C motif) ligand (CXCL)1, CXCL10, chemokine (C-C motif) ligand (CCL)3, and regulated on activation, normal T cell expressed and secreted (RANTES) release in IAV BALF. Olaparib decreased PARylated protein content and p65, IκBα phosphorylation in IAV lung tissues. This study successfully constructed the pneumonia murine model using IAV. Olaparib decreased IAV-induced mortality in mice, lung injury, and cytokine production possibly via modulation of PARP-1/NF-κB axis.

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“…Besides, N, N′-dicyclohexyl-N-arachidonic acylurea, a highly unsaturated fatty acid from Balangen, could inhibit TCRmediated PI3K-Akt signaling pathway, resulting in arrested cell cycle transition from G1 to S phase and lymphocyte hypoproliferation (An et al, 2020). Erucic acid, an active component of Banlangen, markedly reduced CD8 + cytotoxic T lymphocyte recruitment (Liang et al, 2020). It is possible that the chemical constituents of Banlangen might affect the immune function of γδT cells.…”

Section: Discussionmentioning

confidence: 99%

Xiao-Yin-Fang Therapy Alleviates Psoriasis-like Skin Inflammation Through Suppressing γδT17 Cell Polarization

Zhang

Chen

et al. 2021

Front. Pharmacol.

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Psoriasis is an immune-mediated chronic inflammatory skin disease primarily mediated by the activation of interleukin (IL)-17-producing T cells. Traditional Chinese Medicine (TCM) represents one of the most effective complementary and alternative medicine (CAM) agents for psoriasis, which provides treasured sources for the development of anti-psoriasis medications. Xiao-Yin-Fang (XYF) is an empirically developed TCM formula that has been used to treat psoriasis patients in Shanghai Changhai Hospital for over three decades. Imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model was utilized to investigate the therapeutic effects of XYF by the assessment of disease severity and skin thickness. Flow cytometric assay was performed to explore the influence of XYF on skin-related immunocytes, primarily T cells. And, RNA sequencing analysis was employed to determine the alternation in gene expression upon XYF therapy. We discovered that XYF alleviated psoriasis-like skin inflammation mainly through suppressing dermal and draining lymph-node IL-17-producing γδT (γδT17) cell polarization. Moreover, XYF therapy ameliorated the relapse of psoriasis-like dermatitis and prohibited dermal γδT cell reactivation. Transcriptional analysis suggested that XYF might regulate various inflammatory signaling pathways and metabolic processes. In conclusion, our results clarified the therapeutic efficacy and inner mechanism of XYF therapy in psoriasis, which might promote its clinical application in psoriasis patients and facilitate the development of novel anti-psoriasis drugs based on the bioactive components of XYF.

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Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-κB and p38 MAPK pathway

Cited by 49 publications

References 73 publications

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19

Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice

Xiao-Yin-Fang Therapy Alleviates Psoriasis-like Skin Inflammation Through Suppressing γδT17 Cell Polarization

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