Erste tierexperimentelle Ergebnisse eines von einer Polytetrafluoroethylenmembran umhüllten Koronarstents*

Unverdorben, Martin; Spielberger, A.; Schywalsky, M.; Labahn, Dirk; Schneider, M.; Degenhardt, Ralf; Schüttler, J.; Vallbracht, C.

doi:10.1055/s-2001-16980

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Urethane-linked multiblock copolymers (UL-MBCP) modified by fatty acid side chains were used for MSS coating with the anti-restenotic drug sirolimus as a biocompatible drug-eluting stent [186]. MSS stents coated with a polytetrafluoroethylene (PTFE) membrane were found to have an increased vascular lumen without any inflammatory vascular reaction or restenosis [187]. In addition, PTFEP was not found to have thrombus or restenosis on coated stents [188,189].…”

Section: Improvement Of Drug Delivery Propertiesmentioning

confidence: 99%

Surface Modifications of Medical Grade Stainless Steel

Sultana,

Nishina,

Nizami

2024

Coatings

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Medical-grade stainless steel (MSS) is one of the most widely used materials for implantable devices in biomedical applications, including orthopedic stents, dental implants, cardiovascular stents, cranial fixations, and surgical suture materials. Implants are exposed to corrosive body fluids containing chlorides, proteins, and amino acids, resulting in corrosion, wear, toxicity, inflammation, infection, and failure. MSS-based materials exhibit improved corrosion and mechanical resistance and suppress the degradation and release of toxic metal ions. Although MSS is manufactured with a passivating metal oxide layer, its anti-corrosion performance against chlorides and chemicals in body fluids is insufficient. Implants require biocompatibility, bioactivity, hemocompatibility, and sustainability. Antimicrobial activity and sustained drug release are also crucial factors. Therefore, stainless steel with desirable multifunction is in great clinical demand. This comprehensive review summarizes recent advances in the surface modification of MSS-based implants and their biomedical applications, especially in dentistry.

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Section: Improvement Of Drug Delivery Propertiesmentioning

confidence: 99%

Surface Modifications of Medical Grade Stainless Steel

Sultana,

Nishina,

Nizami

2024

Coatings

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Ergebnisse bei verschiedenen Stenttypen und verschiedener Lokalisation

Unverdorben¹

2002

Interventionelle Gefäßtherapie

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Surgery in Peyronie's Disease: Our Experiences with Tunica Plication, Plaque Incision and Grafting with Gore-Tex, and Satisfaction Degree of the Patients

Passavanti¹,

Aloisi²

2015

Arch Renal Dis Manag

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Peyronie's disease is a relatively common condition, with an incidence of 3-9%. It is often associated with diabetes and erectile dysfunction (ED). This condition causes a penile deformity that can affect sexual penetration and lead to psychological disorders because of the difficulty in coping with the situation. Sometime the surgery does not satisfy the patients; we tried to evaluate this aspect of the disease. Materials and methods: We treated 46 patients for recurvatum penis secondary to Peyronie's disease. The clinical examination involved an accurate medical history, a physical examination to identify the plaque, ultrasonography to detect calcified plaque, and a photograph of the erect penis to document the recurvatum and sandglass deformity. In the case of ED, we administered the IIEF-5 and performed intracavernous injection of PGE1; in patients eligible for grafting, we also carried out a dynamic echo colour Doppler of the cavernous corps. Penis length, altogether, was between 11.5 and 14.5 cm (13.25 ± 1 cm). In 40 patients with moderate curvature (45-60°) we carried out tunica plication and in 6 cases with curvature >60° and with ED we performed plaque incision and partial dissection, with grafting strips of polyester fluoropolymer (Gore-Tex). In all cases, we performed an extended dissection of the dorsal plexus and urethra. Results: Correction of the recurvatum was achieved in all cases. In patients undergoing albuginea plication, the shortening of the corpus cavernosum ranged from 0.5 cm (1 case) to 2 cm. Patients with ED, particularly those who received a synthetic graft, continued to take iPDE5, with good erections. The graft has never induced inflammation, scar retractions or pseudo-aneurysm expansion, even in the medium term (5 years). Patient satisfaction was evaluated asking the patient to score it in scale from 1 to 4. The scale was administered 6-8 months after surgery. Patients treated with albuginea plication scored their satisfaction as it follows: 26 patients degree 3 (satisfied enough); 9 patients degree 4 (very satisfied); 4 patients degree 2 (satisfied); 1patient unsatisfied. In patients treated with patch: 2 patients degree 3 and 4 patients degree 4 (Table 1). Conclusions: A thorough diagnostic study of patients with proper indications for surgical treatment coupled with a careful and detailed evaluation of the patient's expectations, followed by an extensive surgical dissection of the corpora cavernosa, provide good results for both tunica plication and the polyester fluoropolymer graft with a good degree of satisfaction of the patients. In our experience, this graft seems free of the complications thus far attributed to synthetic grafts. Through our experiences we understood some relevant aspects of this disease and its therapy, which we are showing in this study. 3 enough satisfied 4 a lot satisfied

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Erste tierexperimentelle Ergebnisse eines von einer Polytetrafluoroethylenmembran umhüllten Koronarstents*

Abstract: In the rabbit iliac artery, stents sheathed with a microporous polytetrafluoroethylene membrane showed good tissue compatibility with no restenosis. These results warrant clinical trials.

Cited by 3 publications

References 8 publications

Surface Modifications of Medical Grade Stainless Steel

Surface Modifications of Medical Grade Stainless Steel

Ergebnisse bei verschiedenen Stenttypen und verschiedener Lokalisation

Surgery in Peyronie's Disease: Our Experiences with Tunica Plication, Plaque Incision and Grafting with Gore-Tex, and Satisfaction Degree of the Patients

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