Errors in Derivations of the Coburn-Forster-Kane Equation for Predicting Carboxyhemoglobin

Smith, Steven R.; Steinberg, Seymour; Gaydos, Joel C.

doi:10.1202/0002-8894(1996)057<0621:eidotc>2.0.co;2

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“…A partially condensed version with 10 input variables (11) is shown in Scheme 1. Thorough subsequent investigations have shown the CFK equation to be rugged and reliable under a variety of conditions (6,(10)(11)(12)(13)(14)(15)(16). On the other hand, this equation is complex to handle and difficult to solve without access to a powerful computer.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Carboxyhemoglobin

Lloyd

Rowe²

1999

Environ. Sci. Technol.

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Carbon monoxide can be lethal at concentrations of less than 0.1%. The kinetics and mechanism of its toxicology have been described elegantly by Coburn et al. (J. Clin. Invest. 1965, 44, 1899−1910): CO combines readily with blood hemoglobin to form carboxyhemoglobin (COHb). When a subject is exposed to potentially hazardous levels of CO, however, the achievement of the equilibrium level of COHb in the bloodstream requires a number of hours. The Coburn equation is complex, using a number of input variables. What is desired is a simple equation, requiring as input only two or three readily available parameters, that will provide a good estimate of COHb concentration with time. Previous efforts to develop such an equation are reviewed. This work provides and tests a new empirical equation to generate COHb concentration−time curves. With this equation and for a given concentration of ambient CO, one can estimate how much of a subject's hemoglobin has been tied up as COHb after a given period of exposure. We believe this to be of value to firefighters, police, and other emergency personnel.

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