Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder

Fitzgerald, Kate D.; Welsh, Robert C.; Gehring, William J.; Abelson, James L.; Himle, Joseph A.; Liberzon, Israel; Taylor, Stephan F.

doi:10.1016/j.biopsych.2004.10.038

Cited by 329 publications

(293 citation statements)

References 54 publications

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“…They feel that they have to get things just right and have to check to make sure. An imaging study revealed greater error-related activation of the rostral anterior cingulate [95], a structure involved in conflict resolution by top-down inhibition of the amygdala, where emotional conflict is generated [48]. Surgical ablation of the anterior cingulate, internal capsule, subcaudate tractotomy, rostral intralaminar and medial thalamic nuclei [96,97] can reduce OCD symptoms (Table 2).…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Deep brain stimulation in Parkinson disease—what went wrong?

Krack

Hariz

2010

Nat Rev Neurol

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Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Deep brain stimulation in Parkinson disease—what went wrong?

Krack

Hariz

2010

Nat Rev Neurol

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“…In the particular case of action incompleteness (i.e., checking behaviors), people may experience inconsistent feelings that ''actions or intentions have been incompletely achieved" (Summerfeldt, Huta, & Swinson, 1998, p. 80), or feel only a weak sense of goal satisfaction. Such conflicting appraisals of one's behaviors have been related to impairments of the ability to monitor actions (Fitzgerald et al, 2005;Gehring, Himle, & Nisenson, 2000;Maltby, Tolin, Worhunsky, O'Keefe, & Kiehl, 2005;Pitman, 1987;Ursu, Stenger, Shear, Jones, & Carter, 2003). For example, Pitman (1987) proposed that compulsive behaviors may stem from a recurrent perception of a ''mismatch signal" informing one of a discrepancy between actual outcomes and intended effects; checking symptoms have been consistently connected with abnormal action-monitoring (Hajcak & Simons, 2002).…”

Section: Introductionmentioning

confidence: 99%

Feeling of doing in obsessive–compulsive checking

Belayachi

Linden

2010

Consciousness and Cognition

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a b s t r a c tResearch on self-agency emphasizes the importance of a comparing mechanism, which scans for a match between anticipated and actual outcomes, in the subjective experience of doing.This study explored the ''feeling of doing" in individuals with checking symptoms by examining the mechanism involved in the experienced agency for outcomes that matched expectations. This mechanism was explored using a task in which the subliminal priming of potential action-effects (emulating outcome anticipation) generally enhances people's feeling of causing these effects when they occur, due to the unconscious perception of a match between primed and observed outcomes. The main result revealed a negative relationship between checking and self-agency for observed outcomes that were primed prior to actions. This suggests that checking individuals fail to grasp the correspondence between actual outcomes of their actions and expected ones. We discuss the possible role of undermined self-agency in checking phenomena and its relationship with cognitive dysfunction.

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“…Converging evidence from neuroimaging studies conducted at rest as well as during symptom provocation suggests that the anterior cingulate cortex as part of a frontal-striatal circuit is involved in the pathophysiology of OCD (2,6). Furthermore, functional MRI (fMRI) studies point toward enhanced error-and conflict-related activity in the anterior cingulate cortex in OCD patients (7,8). Consistent with this, the error-related negativity, a fronto-central event-related brain potential generated by the anterior cingulate cortex following an error (9), has been repeatedly found to be enhanced in OCD patients (10) across all symptom dimensions and unrelated to symptom severity (11).…”

mentioning

confidence: 99%

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

Riesel¹,

Endraß²,

Auerbach³

et al. 2015

AJP

106

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Objective: Overactive performance monitoring, as measured by the error-related negativity in the event-related brain potential, represents one of the most robust psychophysiological alterations in obsessive-compulsive disorder (OCD). It has been proposed as an endophenotype for OCD because it is heritable and more prevalent in families of OCD patients. Consistent with this notion, it is also independent of symptom profile and symptom severity in cross-sectional studies. Longitudinally, it has been shown to be state independent in pediatric patients with OCD. The purpose of the present study was to investigate the state dependency of error monitoring by examining adult OCD patients before and after symptom reduction through cognitive-behavioral therapy (CBT).Method: Error-related and correct-related negativity as electrophysiological indicators of performance monitoring were recorded from 45 OCD patients and 39 healthy comparison subjects while performing a flanker task. Patients were assessed before starting and after completing a standard 30-session CBT, including exposure and response prevention, and healthy comparison subjects were tested after a comparable time interval.Results: Pretreatment, patients with OCD were characterized by enhanced error-related and correct-related negativity compared with healthy comparison subjects. This difference persisted after treatment when symptoms were substantially reduced. There was no significant correlation between symptom improvement and changes in performance monitoring and no difference in performance monitoring between treatment responders and nonresponders.Conclusions: This is the first longitudinal study in adult OCD patients showing stability of enhanced error monitoring following successful symptom reduction through CBT. It supports the hypothesis that overactive performance monitoring is an endophenotype that indicates vulnerability for OCD.

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Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder

Cited by 329 publications

References 54 publications

Deep brain stimulation in Parkinson disease—what went wrong?

Deep brain stimulation in Parkinson disease—what went wrong?

Feeling of doing in obsessive–compulsive checking

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

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