Error correction and improved precision of spike timing in converging cortical networks

Levi, Amir; Spivak, Lidor; Sloin, Hadas E.; Someck, Shirly; Stark, Eran

doi:10.1016/j.celrep.2022.111383

Cited by 14 publications

(24 citation statements)

References 74 publications

(94 reference statements)

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“…2Fcd ). The high gain and short time lag are inconsistent with synaptic transmission in freely-moving mice 47 . Thus, the network vINT-BIP and the dual-sided PYR-BIP analyses suggest that B-spikes correspond to recordings from a non-somatic compartment.…”

Section: Resultsmentioning

confidence: 99%

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Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes

Someck

Levi

Sloin

et al. 2023

Preprint

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Multiple biophysical mechanisms may generate non-negative extracellular waveforms during action potentials, but the origin and prevalence of positive spikes and biphasic spikes in the intact brain are unknown. Using extracellular recordings from densely-connected cortical networks in freely-moving mice, we find that a tenth of the waveforms are non-negative. Positive phases of non-negative spikes occur in synchrony or just before wider same-unit negative spikes. Narrow positive spikes occur in isolation in the white matter. Isolated biphasic spikes are narrower than negative spikes, occurring right after spikes of verified inhibitory units. In CA1, units with dominant non-negative spikes exhibit place fields, phase precession, and phase-locking to ripples. Thus, near-somatic narrow positive extracellular potentials correspond to return currents, and isolated non-negative spikes correspond to axonal potentials. Identifying non-negative extracellular waveforms that correspond to non-somatic compartments during spikes can enhance the understanding of physiological and pathological neural mechanisms in intact animals.

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Section: Resultsmentioning

confidence: 99%

“…Automatic spike sorting was followed by manual adjustment of the clusters. Only well-isolated units were used for further analyses (amplitude >40 μV; L-ratio <0.05; inter-spike interval index <0.2; 47 ).…”

Section: Methodsmentioning

confidence: 99%

Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes

Someck

Levi

Sloin

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Automatic spike sorting was followed by manual adjustment of the clusters. Only well-isolated units were used for further analyses (amplitude >40 µV; L-ratio <0.05; ISI index <0.2 40 ).…”

Section: Methodsmentioning

confidence: 99%

Learning to learn: Single session acquisition of new rules by freely-moving mice

Levi

Aviv

Stark

2023

Preprint

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Learning from examples and adapting to new rules are fundamental attributes of human cognition. However, it is unclear what conditions allow for fast and successful learning. To determine how rapidly freely-moving mice can learn a new rule, we designed a fully automated two-alternative forced choice visual discrimination paradigm in which the rules governing the task can change between sessions. We find that animals can learn a new rule during the very first block of trials. The propensity for single session learning improves over time and can be accurately predicted based on animal experience and rule difficulty. When conditions for generalization from a previous rule are more favorable, mice perform single session learning with higher success rates. Units recorded from hippocampal region CA1 during a previously-learned visual rule exhibit task-related place fields and state-dependent modulation. A mouse trained on visual rules can learn an intra-cortical rule, generated by direct activation of hippocampal CA1 pyramidal cells. Thus, after establishing procedural learning of a paradigm, mice continue to perform and improve at associative operant learning of new rules.

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“…Several types of memory, including implicit short-term memory, have not been studied with invasive techniques. Freely-moving mice have emerged as a robust model for studying various neuronal mechanisms using high density silicon probes recordings combined with optogenetics [66][67][68] . Here, we created a conscious short-term response priming paradigm for mice.…”

Section: Using the Rodent Paradigm To Study The Neurobiological Basis...mentioning

confidence: 99%

Short-term auditory priming in freely-moving mice

Sivroni

Sloin

Stark

2023

Preprint

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Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively. Yet currently there is no behavioral model of short-term priming in lab animals, limiting the study of the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely-moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast to humans, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.

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Error correction and improved precision of spike timing in converging cortical networks

Cited by 14 publications

References 74 publications

Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes

Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes

Learning to learn: Single session acquisition of new rules by freely-moving mice

Short-term auditory priming in freely-moving mice

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