Erratum: Vitamin E decreases bone mass by stimulating osteoclast fusion

Abstract

In the version of this article initially published, it was incorrectly stated that the mice were fed a diet supplemented with α-tocopherol at 600 mg per kg of body weight. Instead, the food itself contained 600 mg of α-tocopherol per kg. The error has been corrected in the HTML and PDF versions of the article.Corrigendum: Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer In the version of this article initially published, due to an oversight by the authors, the first and last names of one the authors, Somasekar Seshagiri, were incorrectly transposed. The error has been corrected in the HTML and PDF versions of the article.Corrigendum: Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy In the version of this article initially published, in Figure 1a, the bar for 3-deoxyglucosone was incorrectly labeled as 3-diacylglycerol. In Figure 6b, the labels for the control and methylglyoxal-treated samples were incorrectly switched. Also, Felix Lasitschka's last name was misspelled as Lasischka. The errors have been corrected in the HTML and PDF versions of the article. In the version of this article initially published, ASEL-CD8 in Figure 3h was incorrectly labeled. The error has been corrected in the HTML and PDF versions of the article.nature medicine volume 18 | number 9 | september 2012 1445 e r r ata a n d co r r i g e n da npg

P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling

“…NFATc1 has an essential role in osteoclastogenesis. In response to activation of Ca 2+ /calcineurin signaling, NFATc1 is a key modulator, which activates transcription of a series of key osteoclast genes by translocating to the nucleus ( 21 ). NFATc1 is not only required but also sufficient for osteoclastogenesis, as its overexpression in osteoclast precursors has been shown to induce osteoclast differentiation in the absence of RANKL ( 22 ).…”

Effect of Vitamins D and E on the Proliferation, Viability, and Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study

“…Regarding the in vitro effect of vitamin E on MSC proliferation, we observed a significant decline in the number of cells at all doses (from 0.75 to 12 µ M), from 120 h of treatment. Studies evaluating changes in cell proliferation induced by vitamin E treatment are contradictory: Fujita et al have investigated the action of vitamin E in mice deficient in the transfer protein of α -tocopherol in comparison with a wild type mouse model, documenting that osteoblastic differentiation and proliferation were not altered by vitamin E [ 22 ]. Additionally, Urban et al have observed that vitamin E treatment did not increase the osteoblast proliferation in vitro; however, they argue that high doses of this vitamin can generate toxic effects preventing osteoblast differentiation and proliferation [ 23 ].…”