Erratum: Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression

The negative impact of depression on the course and outcome of somatic disorders is well-known and has a solid theoretical basis. The analyses of prospective studies confirm the role of depression as an independent and significant risk factor for widespread chronic somatic disorders including such severe and life-threatening conditions as cardiovascular diseases, diabetes and oncological pathology. The majority of somatic disorders and depression are the part of the big class of hereditary diseases with multifactorial character and polygenic nature. It is likely, that the genetic risk diversity of these diseases in population is close. There is also a high probability of genetic risks levels overlap (or of common «cluster») of two or more diseases in one individual, with one disorder being major depression. In that case such diseases could be considered «genetically comorbid» and manifestation of one disease could alter the risks of other. Precise and informative diagnostic tools could detect subsyndromal depression that could be the prognostic sign of the high risk and rapid manifestation of somatic diseases. Thus, patients with depressive disorder could be considered as a group with high risks of diverse range of somatic pathology. The coalescence of fundamental biomedical scientists and internists (psychiatrists and other physicians) could lead to the elaboration of specific complex preventative measures including social ones.

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The prognostic role of depression as a predictor of chronic somatic diseases manifestation

Незнанов

Кибитов

Рукавишников

et al. 2018

Terapevticheskii arkhiv

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Traumatic life experiences and major depression: an overview

Risio¹,

Battaglia²,

Camardese³

et al. 2016

International Journal of Multidisciplinary Trauma Studies

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Erratum: Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression

Cited by 2 publications

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The prognostic role of depression as a predictor of chronic somatic diseases manifestation

The prognostic role of depression as a predictor of chronic somatic diseases manifestation

Traumatic life experiences and major depression: an overview

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