Erratum: Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, Gillian; Collie-Duguid, Eliana; Murray, G. I.; Gilbert, Fiona J.; Denison, Alan; McKiddie, Fergus; Ahearn, Trevor; Fleming, Irvin D.; Leeds, John S.; Phull, Perminder; Park, K; Nanthakumaran, Shayanthan; Matula, K M; Grabsch, Heike; Tan, P; Welch, Andrew; Schweiger, L.; Dahle-Smith, Åsa; Urquhart, Gordon; Finegan, M; Petty, Russell

doi:10.1038/bjc.2016.139

Cited by 6 publications

(3 citation statements)

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“…To validate the association between EGFR amplification (by FISH) and immune cell infiltration (by IHC), 124 GOA FFPE pretreatment tumour specimens within a TMA were analyzed as previously published. 17 , 28 The TMA was an external patient cohort obtained from NHS Grampian, Scotland. Two cores per patient, from the centre of the tumour, were taken.…”

Section: Resultsmentioning

confidence: 99%

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

Baxter,

Spender,

Cairns

et al. 2024

ESMO Open

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Section: Resultsmentioning

confidence: 99%

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

Baxter,

Spender,

Cairns

et al. 2024

ESMO Open

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“…It is known for controlling food intake and energy balance via its receptor (LepRb). Several clinical studies reported that elevated serum leptin levels might serve as a biological marker and predictor for depression ( 89 ). Due to these findings Leptin-LepRb might be a potential diagnostic marker and therapeutic target in patients with GC suffering from depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

Influencing Factors and Effects of Treatment on Quality of Life in Patients With Gastric Cancer—A Systematic Review

Rupp¹,

Stengel

2021

Front. Psychiatry

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Background: Gastric cancer (GC) is one of the leading causes of death worldwide. It is associated with several disease-related impairments contributing to the psycho-social burden of those patients, such as deterioration of well-being and overall quality of life (QOL). The aim of this study is to present the wide range of factors potentially impacting patients' overall well-being and possible preventive interventions.Methods: This systematic review was conducted in October 2020 with a search in the PubMed, MedLine, PsycInfo, and Google Scholar databases. We used the keywords “gastric cancer,” “gastric neoplasm,” and each of them combined with “quality of life,” “depression,” and “anxiety” to identify all relevant articles reporting about potential impact factors influencing the overall well-being of patients suffering from gastric cancer.Results: Finally, 125,490 articles were found, of which 125,431 were excluded in several steps of screening. Inclusion criteria were studies carried out on human ≥18 years of age, studies in English or German language, clinical trials, registry-based studies, cohort studies, population-based studies, and certain titles and abstracts. After screening for eligibility 35 potential factors influencing overall well-being in patients with GC were identified and classified into 9 important categories: genetic condition, treatment method, blood markers, nutritional status, daily living, state of health, mental state, supportive care, and alternative treatment.Conclusion: Since various factors are involved in the development of patients' overall well-being, timely treatment of psycho-social impairments by physicians and psychologists is of enormous importance. Preventing psycho-social burden by improving patients' QOL should be of high importance in the treatment regimen of patients with GC.

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“…Leptin, a hormone, is primarily produced by adipose tissue and secreted into plasma [10] and could be detected in various tissues [11, 12]. Leptin was initially recognized to control food intake and energy balance [10] and functions via its receptor (LepRb) [13].…”

Section: Introductionmentioning

confidence: 99%

Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression

Pan

Zhou

et al. 2017

BioMed Research International

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Depression is the most common psychiatric disorder among cancer patients. Studies have not only highlighted that leptin and its receptor (LepRb) are independent poor prognostic factors in gastric cancer (GC) patients but also shown that the leptin-LepRb is necessary for antidepressant-like behaviors. In this study, we examined the serum and tissue leptin-LepRb expression in GC patients. Enzyme-linked immunosorbent assay showed that depressive GC patients had significantly higher serum leptin-LepRb than healthy donors. Leptin-LepRb levels in GC tissues were also significantly higher than in matched paracarcinoma tissues using real-time RT-PCR. Moreover, we observed that both serum and tissue leptin-LepRb were significantly higher in depressive GC patients than those in nondepressive GC patients. Further, the patients with high tumor stage tend to have higher leptin-LepRb mRNA levels than that with low tumor stage. Together, our findings suggest that leptin-LepRb plays an important role in the pathogenesis and depression in GC. Leptin-LepRb therefore could be a potential diagnostic marker and therapeutic target in GC patients with depression.

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Erratum: Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Cited by 6 publications

References 0 publications

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

Influencing Factors and Effects of Treatment on Quality of Life in Patients With Gastric Cancer—A Systematic Review

Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression

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