Erratum to: Up-Regulation of miR-21 Expression Predicate Advanced Clinicopathological Features and Poor Prognosis in Patients with Non-Small Cell Lung Cancer

Tian, Lei; Shan, Weiyu; Zhang, Yufei; Lv, Xuejun; Li, Xuehua; Wei, Caiyun

doi:10.1007/s12253-015-0004-y

Cited by 3 publications

(3 citation statements)

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“…As one of the most important regulators of the pathogenesis of human disease through the regulation of gene expression, miRNAs has been reported to serve roles in the progression of human lung cancer, including miR-196a, miR-200c and miR-204 ( 24 – 26 ). miR-21 is one of the miRNAs reported to be associated with apoptosis in human NSCLC cells ( 17 , 18 ). However, more research into the potential role of miR-21 is required.…”

Section: Discussionmentioning

confidence: 99%

“…These previous results provide a potential approach for developing miRNA-based therapeutic strategies for the treatment of NSCLC. In a correlation study of miR-21 in lung cancer cells, miR-21 was investigated as a potential serum biomarker, and diagnostic and prognostic indicator for NSCLC ( 16 – 18 ). However, the molecular mechanism underlying the role of miR-21 in lung cancer remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-21 increases cell viability and suppresses cellular apoptosis in non-small cell lung cancer by regulating the PI3K/Akt signaling pathway

Wang

Cai

Hong

et al. 2017

Molecular Medicine Reports

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MicroRNA (miRNA/miR), a type of non-coding RNA molecule, is able to inhibit the expression of target genes at multiple stagess. There are 800–1,000 known miRNAs in the human genome, which serve important roles in cell proliferation, differentiation, apoptosis and migration. Previous studies have demonstrated that the expression of miR-21 is upregulated in numerous types of malignant tumor, and that miR-21 participates in the occurrence and development of tumors via complex regulatory mechanisms. The present study aimed to investigate the association between miR-21 expression, cell viability and apoptosis in a lung cancer cell line, and to elucidate the potential mechanisms. miR-21 or small interfering RNA against miR-21 were transfected into A549 non-small cell lung cancer cells. The mRNA expression of miR-21 was confirmed. Cell viability and apoptosis were examined using MTT and flow cytometric assays, respectively. The expression of certain apoptosis-associated proteins was detected by western blotting. The results of the present study demonstrated that miR-21 was able to increase the proliferation of A549 cells by inhibiting cellular apoptosis. miR-21 inhibited apoptosis by modulating the activation of the phosphatidylinositol 3-kinase/Rac-α serine/threonine protein kinase (Akt) pathway in A549 cells. Correspondingly, inhibition of Akt decreased the apoptosis of A549 cells in miR-21 siRNA-treated cells. Therefore, the results of the present study demonstrated that miR-21 increased cell viability by inhibiting apoptosis, through regulation of Akt activation. The present study demonstrated that miR-21 may be involved in the progression of lung cancer and may be a novel therapeutic target for the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-21 increases cell viability and suppresses cellular apoptosis in non-small cell lung cancer by regulating the PI3K/Akt signaling pathway

Wang

Cai

Hong

et al. 2017

Molecular Medicine Reports

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“…Yang et al reported that miR-564 functions as a tumor suppressor in human lung cancer by targeting ZIC3 15. Tian et al stated that miR-21 overexpression predicts advanced clinicopathological features and poor prognosis in patients with non-small-cell lung cancer (NSCLC) 16. Hence, the correlation between miRNAs and lung cancer should be studied in order to investigate the tumor pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

miRNA-19 promotes non-small-cell lung cancer cell proliferation via inhibiting CBX7 expression

Peng¹,

Guan²,

Gao³

2018

OTT

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BackgroundmiR-19 is a critical carcinogenic miRNA that participates in important biological processes of human malignancies. CBX7 plays a key role in lung cancer development and progression. In the present study, for the first time, we investigated the correlation between miR-19 and CBX7 in non-small-cell lung cancer (NSCLC).MethodsmiR-19 expression in NSCLC tissues and lung cancer cell lines was detected using quantitative reverse transcriptase PCR (qRT-PCR). Luciferase reporter assay, qRT-PCR, Western blot, and immunohistochemical assay were conducted to identify the target reaction of miR-19 and CBX7. Moreover, the influence of miR-19 on lung cancer cell proliferation, migration, and invasion was studied including cell counting kit-8 assay, scratch assay, transwell assay, flow cytometry assay, and staining assays.ResultsmiR-19 was overexpressed in NSCLC tissues and lung cancer cell lines. Luciferase reporter assay demonstrated that miR-19 could inhibit CBX7 expression via binding to the 3′-UTR of CBX7. Furthermore, miR-19 remarkably decreased CBX7 protein and mRNA expression. Additionally, overexpression of miR-19 could significantly enhance lung cancer cell proliferation and migration.ConclusionmiR-19 functions as a tumor accelerator promoting lung cancer cell proliferation through targeting CBX7 and inhibiting its expression.

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MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)

et al. 2018

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Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer worldwide. The high mortality rate of NSCLC is due to a limited number of diagnosis being made at an early stage of disease. Therefore, the development of a novel biological marker for the diagnosis and prognosis prediction of NSCLC remains urgent. Current literature shows that microRNA-21 (miRNA-21/miR-21), as an oncogenic miRNA, is involved in the growth, metastasis and apoptosis of NSCLC cells through its control of various target molecules and signaling pathways. Notably, a growing body of evidence further shows that miR-21 is closely associated with the prognosis prediction, recurrence and diagnosis of cancer patients, indicating that miR-21 may be a novel promising biomarker for the diagnosis and prognosis prediction of NSCLC. The present review aimed to provide a summary of recent findings on the associated progression toward finding a novel biomarker for NSCLC.

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Erratum to: Up-Regulation of miR-21 Expression Predicate Advanced Clinicopathological Features and Poor Prognosis in Patients with Non-Small Cell Lung Cancer

Cited by 3 publications

References 0 publications

MicroRNA-21 increases cell viability and suppresses cellular apoptosis in non-small cell lung cancer by regulating the PI3K/Akt signaling pathway

MicroRNA-21 increases cell viability and suppresses cellular apoptosis in non-small cell lung cancer by regulating the PI3K/Akt signaling pathway

miRNA-19 promotes non-small-cell lung cancer cell proliferation via inhibiting CBX7 expression

MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)

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