Erratum to “Topographic and functional neuroanatomical study of GABAergic disinhibitory striatum–nigral inputs and inhibitory nigrocollicular pathways: Neural hodology recruiting the substantia nigra, pars reticulata, for the modulation of the neural activity in the inferior colliculus involved with panic-like emotions” [J. Chem. Neuroanat. 32 (2006) 1–27]

Castellan-Baldan, Lissandra; Kawasaki, Mateus da Costa; Ribeiro, Sandro J.; Calvo, Fabrício; Corrêa, Vani Maria Alves; Coimbra, Norberto Cysne

doi:10.1016/j.jchemneu.2006.12.003

Cited by 3 publications

(2 citation statements)

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“…The microinjection of AvTx8 into the nigral area in rodents elicited a complex set of behaviors, such as antipanic (antiaversive) responses with the AvTx8 microinjections in the substantia nigra pars reticulata of rodents attenuated the panic attack‐like responses elicited by GABAergic disinhibition in dorsal midbrain with intramesencephalic administration of a single dose of bicuculline. Based on these results, we suggest that AvTx8 may be acting as an agonist of GABA A receptors in the ventral mesencephalon, and consequently modulating the activity of dorsal midbrain neurons that regulate affective states …”

Section: Introductionmentioning

confidence: 80%

“…Previously, we have demonstrated that the venom of A. vicina has a panicolytic‐like effect in rats, possibly affecting the activity of nigro‐tectal neurotransmission of the striato‐nigral/nigro‐tectal connexions. In addition, disorders in GABA‐signaling pathways are known to be involved in emotional control, and in a number of neurological diseases, such Alzheimer, as shown in a mouse model of memory impairment, insomnia, and neuropathic pain …”

Section: Discussionmentioning

confidence: 99%

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Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission

Pizzo

Beleboni

Carolino

et al. 2017

J Biochem & Molecular Tox

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Arthropod venoms are sources of molecules that may be useful tools to investigate molecular mechanisms of putative new medicines and laboratory drugs. Here we show the effects of the compound agelaiatoxin-8 (AVTx8), isolated from Agelaia vicina venom, on γ-aminobutyric acid (GABA) neurotransmission in rat brain synaptosomes. Analysis reveals that AvTx8 is composed by 14 amino acid residues with a molecular weight (MW) of 1567 Da. AvTx8 increased GABA release and inhibited GABA uptake in synaptosomes from rat cerebral cortex. AvTx8 inhibited GABA uptake and increased GABA release in the presence of Ca , Na , and K channel blockers, suggesting that it acts directly on GABA transporters. In addition, AvTx8 significantly decreases GABA binding in synaptic membranes from rat brain cortex, suggesting that it also modulates the activity of GABA receptors. Moreover, AvTx8 decreased GAT-1- and GAT-3-mediated GABA uptake in transfected COS-7 cells. Accordingly, we suggest that AvTx8 modulates GABA neurotransmission and might provide a novel entry point for identifying a new class of GABA-modulating neuroprotective drugs.

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission

Pizzo

Beleboni

Carolino

et al. 2017

J Biochem & Molecular Tox

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Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour

Ullah

Anjos‐Garcia

Mendes-Gomes

et al. 2017

Behavioural Brain Research

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5‐HT1A and 5‐HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus

Ramsey

Sinha

Hurley

2010

Eur J of Neuroscience

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Serotonin is a physiological signal that translates both internal and external information about behavioral context into changes in sensory processing through a diverse array of receptors. The details of this process, particularly how receptors interact to shape sensory encoding, are poorly understood. In the inferior colliculus, a midbrain auditory nucleus, serotonin (5-HT) 1A receptors have suppressive and 5-HT1B receptors have facilitatory effects on evoked responses of neurons. We explored how these two receptor classes interact by testing three hypotheses: that they 1) affect separate neuron populations, 2) affect different response properties, or 3) have different endogenous patterns of activation. The first two hypotheses were tested by iontophoretic application of 5-HT1A and 5-HT1B receptor agonists individually and together to neurons in vivo. 5-HT1A and 5-HT1B agonists affected overlapping populations of neurons. During coapplication, 5-HT1A and 5-HT1B agonists influenced spike rate and frequency bandwidth additively, with each moderating the effect of the other. In contrast, although both agonists individually influenced latencies and interspike intervals, the 5-HT1A agonist dominated these measurements during co-application. The third hypothesis was tested by applying antagonists of the 5-HT1A and 5-HT1B receptors. Blocking 5-HT1B receptors was complementary to activation of the receptor, but blocking 5-HT1A receptors was not, suggesting the endogenous activation of additional receptor types. These results suggest that cooperative interactions between 5-HT1A and 5-HT1B receptors shape auditory encoding in the IC, and that the effects of neuromodulators within sensory systems may depend nonlinearly on the specific profile of receptors that are activated.

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Cited by 3 publications

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Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission

Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission

Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour

5‐HT1A and 5‐HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus

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