Erratum to: To the article “Preventive Efficacy of Oxidized Dextran and Pathomorphological Processes in Mouse Lungs in Avian Influenza A/H5N1” by O. V. Potapova, V. A. Shkurupiy, T. V. Sharkova, A. V. Troitskiy, N. G. Lusgina, and A. M. Shestopalov, Vol. 150, No. 6, pp. 707-710, April, 2010

Abstract

In this article the summary was incorrectly translated. The following is the correct text:Oxidized dextran (60 kDa) exerted a pronounced preventive effect in laboratory mice infected with avian infl uenza subtype H5N1 A/Goose/Krasnoozerskoye/627/05 virus, which manifested in a signifi cant increase in mouse lifetime (by 24.4%) and a decrease in mortality rate (3.3-fold). This was probably related to signifi cant alleviation of pathological changes in the lungs and severity of hemodynamic and infl ammatory complications and early fi brosis.Also the Figure 1 should look like the following:Mortality MLT

Preventive Efficacy of Oxidized Dextran and Pathomorphological Processes in Mouse Lungs in Avian Influenza A/H5N1

“…Fibrosis was observed primarily in the peribronchial and perivascular areas, at the sites of infl ammatory cell infi ltrates, where great amounts of mononuclears were concentrated. Volume density of fi brotic tissue in the lungs of mice from H5N1 group during the whole period and on day 10 was 13-fold higher than in group H5N1+OD (Table 1), which probably attests to an increase in the IFN-γ level [4], as well as for antifi brotic effects of OD previously demonstrated in experiments on mice infected with M. tuberculosis [2,6].…”

“…The selected A/H5N1 infl uenza virus strain was detected in Novosibirsk region in 2005, it is highly pathogenic and replicates in all organs of mammals (mice) [2]. All virological experiments were carried out at Vector State Research Center of Virology and Biotechnology, Federal Service for Surveillance on Consumer Rights (Novosibirsk region, Kol'tsovo).…”

“…According to previously obtained data [2], oxidized dextran (OD) with a molecular weight of 60 kDa, which is tropic for vacuolar apparatus, particularly in MPS cells, can be regarded as a promising compound [6]. In addition, along with the absence of toxic properties, dextrans were shown to exert detoxifi cation and hepatoprotective properties and intensify plastic properties in cell promoting regeneration in damaged organs [2,6].…”

“…In addition, along with the absence of toxic properties, dextrans were shown to exert detoxifi cation and hepatoprotective properties and intensify plastic properties in cell promoting regeneration in damaged organs [2,6]. Since OD administration has no direct effects on the virus, the risk of the development drug resistance in infl uenza viruses is excluded [6].…”

Structural and Functional Changes in Pulmonary Macrophages and Lungs of Mice Infected with Influenza Virus A/H5N1 A/goose/Krasnoozerskoye/627/05

“…Mammals infected with infl uenza A are characterized by signifi cant changes in the lungs and pulmonary compartment of the mononuclear phagocyte system (MPS) [1,3,4]. However, the pathogenesis of lung damage during infection of mice with infl uenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05 is poorly understood.…”