Erratum to “The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells” [Eur. J. Pharmacol. 641 (2010) 29-34]

Dozio, Elena; Ruscica, Massimiliano; Passafaro, Luca; Dogliotti, Giada; Steffani, Liliana; Marthyn, Paola; Pagani, Alessandra Almeida Castro; Demartini, G.; Esposti, D.; Fraschini, F.; Magni, Paolo

doi:10.1016/j.ejphar.2010.10.001

Cited by 5 publications

(5 citation statements)

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“…They promote the ending of the inflammatory process ( 219 ). In human breast cancer cells ALA produce inhibition of cell proliferation and activate apoptosis ( 220 ). In diabetic rats, ALA increases insulin sensitivity and restored lipid and glucose metabolic abnormalities ( 221 ).…”

Section: The Polyunsaturated Fatty Acids Effects On Immunomodulationmentioning

confidence: 99%

The relationship between nutrition and the immune system

Munteanu

Schwartz

2022

Front. Nutr.

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Nutrition plays an essential role in the regulation of optimal immunological response, by providing adequate nutrients in sufficient concentrations to immune cells. There are a large number of micronutrients, such as minerals, and vitamins, as well as some macronutrients such as some amino acids, cholesterol and fatty acids demonstrated to exert a very important and specific impact on appropriate immune activity. This review aims to summarize at some extent the large amount of data accrued to date related to the modulation of immune function by certain micro and macronutrients and to emphasize their importance in maintaining human health. Thus, among many, some relevant case in point examples are brought and discussed: (1) The role of vitamin A/all-trans-retinoic-acids (ATRA) in acute promyelocytic leukemia, being this vitamin utilized as a very efficient therapeutic agent via effective modulation of the immune function (2) The involvement of vitamin C in the fight against tumor cells via the increase of the number of active NK cells. (3) The stimulation of apoptosis, the suppression of cancer cell proliferation, and delayed tumor development mediated by calcitriol/vitamin D by means of immunity regulation (4) The use of selenium as a cofactor to reach more effective immune response to COVID vaccination (5). The crucial role of cholesterol to regulate the immune function, which is demonstrated to be very sensitive to the variations of this macronutrient concentration. Other important examples are reviewed as well.

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Section: The Polyunsaturated Fatty Acids Effects On Immunomodulationmentioning

confidence: 99%

The relationship between nutrition and the immune system

Munteanu

Schwartz

2022

Front. Nutr.

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“…ALA enhanced apoptosis and suppressed cell proliferation of human breast cancer cell line [31]. ALA also induced hepatoma cells apoptosis [32] to exert antitumor effects by suppression of PI3K/Akt pathway.…”

Section: Introductionmentioning

confidence: 99%

The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

Liu

Shi

2019

BioMed Research International

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Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

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“…1,2 Most importantly, LA is a natural compound and coenzyme with sufficient safety information, 3,4 which facilitates its use in cancer patients to support chemotherapy. It has been previously reported that LA could initiate the apoptosis of various cancer cells, [5][6][7] which is the primary mechanism of anticancer-drugsinduced cell death. Even the role of autophagy (an alternative cell death pathway) in cancer treatment is complicated, and modulating autophagy has recently emerged as a promising therapeutic approach.…”

Section: Introductionmentioning

confidence: 99%