Erratum to: The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: A case report and review of the literature

Ho, Andrew; Szulakowski, Patryk; Mohamid, Waria

doi:10.1186/s12885-015-1601-6

Cited by 2 publications

(2 citation statements)

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“…The condition of our patient with both hepatocellular carcinoma (HCC) and gastric signet-ring cell carcinoma who developed PTTM deteriorated faster than that of patients with gastric carcinoma only. Furthermore, we have reviewed 19 reported cases (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). We present the following article in accordance with the CARE reporting checklist (available at http://dx.doi.org/10.21037/tcr-20-3107).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Shen¹,

Li²,

Jiang³

et al. 2021

Transl Cancer Res TCR

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Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cancer-related complication characterized by intimal proliferation in the pulmonary small arteries with or without tumor emboli, which can be fatal due to progressive pulmonary hypertension (PH). And PTTM is hard to be confirmed during lifetime; hence, it is vital to pay more attention to high-risk PTTM, which may progress quickly.PTTM patients have an extremely poor prognosis. Here, we have reported a case of a patient with both hepatocellular carcinoma (HCC) and gastric signet-ring cell carcinoma who presented with dyspnea and died rapidly and was diagnosed with suspected PTTM. In addition, we have reviewed some related literature. This patient showed a poorer prognosis, with a survival time of only 3 days after oxygen supplementation (very poor compared to the average level of PTTM patients caused by gastric carcinoma only, which was 18 days according to our summary). Besides, respiratory discomfort is the main symptom of PTTM. Abnormal pulmonary imaging was reported with the appearance of septal thickening, ground-glass opacities, small nodules, pleural effusion, and a tree-in-bud pattern in PTTM patients. No effective therapeutic options have been established for PTTM. PTTM should be considered in patients with cancer who progress to rapid respiratory failure and PH, especially in patients with multiple tumors whose condition is more likely to deteriorate quickly.

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Section: Introductionmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Shen¹,

Li²,

Jiang³

et al. 2021

Transl Cancer Res TCR

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“…Pulmonary tumour thrombotic microangiopathy (PTTA) is a very rare, yet invariably fatal, oncological cause of pulmonary hypertension (PHT) 1. Histologically variable, PTTA most commonly originates as a gastric adenocarcinoma, however it has also been reported as a secondary process to pancreatic, prostate, renal and lung carcinoma of various subtypes 2 3.…”

Section: Introductionmentioning

confidence: 99%

Rare cause of pulmonary hypertension – pulmonary tumour thrombotic microangiopathy

et al. 2019

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Pulmonary tumour thrombotic microangiopathy (PTTA) is a rare but lethal cause of pulmonary hypertension (PHT). Its underlying mechanism is believed to be fibrocellular intimal proliferation and microthrombosis. It has been reported in association with gastric adenocarcinoma and breast, pancreatic and lung cancers. The diagnosis is often made on postmortem examination due to the absence of diagnostic criteria and its rare occurrence. We describe the case of a middle-aged man who presented with rapidly progressive PHT. He deteriorated into multiorgan failure despite aggressive medical therapy and died 4 weeks after his initial presentation. A postmortem examination confirmed the diagnosis of PTTA in addition to the finding of signet cell gastric adenocarcinoma. This case highlights the lethal nature of this rare condition, the ongoing challenges in making an antemortem diagnosis, and the importance of postmortem examination in determining the cause of death to provide closure for both, the treating physician and the family.

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Erratum to: The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: A case report and review of the literature

Cited by 2 publications

References 1 publication

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Pulmonary tumor thrombotic microangiopathy of patient with both hepatocellular carcinoma and gastric signet-ring cell carcinoma: a case report and review of literature

Rare cause of pulmonary hypertension – pulmonary tumour thrombotic microangiopathy

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