Erratum to “Synthesis, biodistribution and antitumor activity of hematoporphyrin–platinum(II) conjugates” [Bioorg. Med. Chem. (2003) 1753–1760]

Kim, Yeong-Sang; Song, Rita; Kim, Dong Hyun; Jun, Mira; Sohn, Youn Soo

doi:10.1016/j.bmc.2004.01.004

Cited by 13 publications

(17 citation statements)

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“…A series of porphyrin-platinum conjugates, where derivatives of cisplatin, carboplatin or oxaliplatin were used as cytotoxic agents, were studied with respect to cytotoxicity and phototoxicity against cancer and normal cells. They exhibited a synergistic antiproliferative effect, responsible also for a genotoxic activity resulting from DNA platination [153][154][155]. Organometallic ruthenium complexes constitute another group of metal complexes that might be interesting as peripheral substituents of porphyrins [156][157][158].…”

Section: Introduction Of Various Substituents Into the Porphyrin Frammentioning

confidence: 99%

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dąbrowski

Pucelik

Regiel-Futyra

et al. 2016

Coordination Chemistry Reviews

250

197

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Section: Introduction Of Various Substituents Into the Porphyrin Frammentioning

confidence: 99%

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dąbrowski

Pucelik

Regiel-Futyra

et al. 2016

Coordination Chemistry Reviews

250

197

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“…To improve their cellular uptake and phototoxicities, photosensitizers have been coupled to a wide range of molecules. Complexes of porphyrins (hematoporphyrin, tetraphenylporphyrin) coordinated to platinum derivatives (such as cisplatin or oxaliplatin) were developed a few years ago to combine the cytotoxicity of platinum with the photodynamic activity of porphyrins with promising anticancer effects [10][11][12][13][14]. However, platinum derivatives are associated with high toxicity and resistance mechanisms [15]; therefore, the use of a different metal is very appealing to overcome the drawbacks associated with platinum [16,17].…”

Section: Introductionmentioning

confidence: 99%

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

et al. 2008

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Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) derivatives (arene is C 6 H 5 Me or p-Pr i C 6 H 4 Me) were prepared and evaluated as potential dual photosensitizers and chemotherapeutics in human Me300 melanoma cells. In the absence of light, all tetranuclear complexes were cytotoxic (IC 50 B 20 lM), while the mononuclear derivatives were not (IC 50 C 100 lM). Kinetic studies of tritiated thymidine and tritiated leucine incorporations in cells exposed to a low concentration (5 lM) of tetranuclear p-cymene derivatives demonstrated a rapid inhibition of DNA synthesis, while protein synthesis was inhibited only later, suggesting arene ruthenium-DNA interactions as the initial cytotoxic process. All complexes exhibited phototoxicities toward melanoma cells when exposed to laser light of 652 nm. At low concentration (5 lM), LD 50 of the mononuclear derivatives was between 5 and 10 J/cm 2 , while for the tetranuclear derivatives LD 50 was approximately 2.5 J/cm 2 for the [Ru 4 (g 6 -arene) 4 (tetra-4-pp)Cl 8 ] complexes and less than 0.5 J/cm 2 for the [Ru 4 (g 6 -arene) 4 (tetra-3-pp)Cl 8 ] complexes. Examination of cells under a fluorescence microscope revealed the [Ru 4 (g 6 -arene) 4 (tetra-4-pp)Cl 8 ] complexes as cytoplasmic aggregates, whereas the [Ru 4 (g 6 -arene) 4 (tetra-3-pp)Cl 8 ] complexes were homogenously dispersed in the cytoplasm. Thus, these complexes present a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizer.

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“…The antitumor activity of the compounds was assayed in vitro and in vivo against the leukemia L1210 [14]. The in vitro activity is expressed as inhibitory concentration (IC 50 , lM), which is the concentration of drugs producing 50% inhibition of cell growth.…”

Section: Bioassay Of Antitumor Activitymentioning

confidence: 99%

“…However, its severe side effects and acquired cross-resistance restrict its clinical use, and therefore, many platinum complexes have been designed and synthesized to overcome such disadvantages of cisplatin [7][8][9][10][11][12][13][14][15]. As the result, in addition to carboplatin, recently two more platinum(II) complexes, that is, oxaliplatin and nedaplatin, have been approved for clinical use.…”

Section: Introductionmentioning

confidence: 99%

Coordination modes vs. antitumor activity: synthesis and antitumor activity of novel platinum(II) complexes of N -substituted amino dicarboxylic acids

Kim

Song²,

Chung³

et al. 2004

Journal of Inorganic Biochemistry

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Erratum to “Synthesis, biodistribution and antitumor activity of hematoporphyrin–platinum(II) conjugates” [Bioorg. Med. Chem. (2003) 1753–1760]

Cited by 13 publications

References 0 publications

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Coordination modes vs. antitumor activity: synthesis and antitumor activity of novel platinum(II) complexes of N -substituted amino dicarboxylic acids

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