Erratum to: Surface functionalization by covalent immobilization of an innovative carvacrol derivative to avoid fungal biofilm formation

Gharbi, Aïcha; Legigan, Thibaut; Humblot, Vincent; Papot, Sébastien; Imbert, Christophe; Berjeaud, Jean‐Marc

doi:10.1186/s13568-015-0141-4

Cited by 1 publication

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References 1 publication

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“…Studies have shown that adding tannin to zein to prepare zein/tannin nerve conduit, can enhance the effect of zein nerve conduit and promote the regeneration of peripheral nerves [81]. Compared with carvacrol, carvacrol propionate formed by esterification of carvacrol with propionyl chloride in the presence of triethylamine (TEA) has stronger antiinflammatory, analgesic and antihyperalgesic functions [82], carvacrol esters and ethers with amino groups formed by functionalizing the phenolic group of carvacrol can be anchored to the gold surface to develop antibacterial coatings [83]. Thymol combined with nonsteroidal antiinflammatory drugs can reduce the production of reactive oxygen species and reduce the probability of adverse reactions such as gastric mucosal damage [84]，which may be a new application of nonsteroidal anti-inflammatory drugs.…”

Section: Drug Loadingmentioning

confidence: 99%

Polymers containing natural plant phenolic compounds for peripheral nerve injury

Zheng

Qiu

et al. 2022

BAB

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Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy，chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.

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