Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Schmutzhard, Joachim; Lackner, Peter; Helbok, Raimund; Hurth, Helene; Aregger, Fabian Cedric; Muigg, Veronika; Kegele, Josua; Bunk, Sebastian; Oberhammer, Lukas; Fischer, Natalie; Pinggera, Leyla; Otieno, Allan; Ogutu, Bernards; Agbenyega, Tsiri; Ansong, Daniel; Adegnika, Ayôla Akim; Issifou, Saadou; Zorowka, Patrick; Krishna, Sanjeev; Mordmüller, Benjamin; Schmutzhard, Erich; Kremsner, Peter G.

doi:10.1186/s12916-016-0616-4

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“…Within two days, most children will have recovered from or succumbed to the disease ( 7 ). 14-25% of children recovering from CM suffer from long-term sequelae like cognitive and hearing impairments ( 8 , 9 ). As there is no specific therapy beyond symptomatic neurocritical management, all strategies aim to eliminate the parasite from the system while targeting symptoms arising from severe complications like respiratory distress or convulsions.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Malaria: Current Clinical and Immunological Aspects

Albrecht-Schgoer

Lackner²,

Schmutzhard

et al. 2022

Front. Immunol.

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This review focuses on current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, current knowledge of the underlying molecular mechanisms is highlighted. Furthermore, and in the light of significant limitations in preventative diagnosis and treatment of cerebral malaria, this review mainly discusses our understanding of immune mechanisms in the light of the most recent research findings. Remarkably, the newly proposed CD8+ T cell-driven pathophysiological aspects within the central nervous system are summarized, giving first rational insights into encouraging studies with immune-modulating adjunctive therapies that protect from symptomatic cerebral participation of Plasmodium falciparum infection.

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Section: Introductionmentioning

confidence: 99%