Erratum to: No training required: experimental tests support homology-based DNA assembly as a best practice in synthetic biology

Azizi, Afnan; Lam, Wilson; Phenix, Hilary; Tepliakova, Lioudmila; Roney, Ian J.; Jedrysiak, Daniel; Power, Alex; Gupta, Vaibhav; Elnour, Nada; Hanzel, Martin; Tzahristos, Alexandra C; Sarwar, Shihab; Kærn, Mads

doi:10.1186/s13036-015-0013-0

Cited by 7 publications

(5 citation statements)

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“…The decrease of blood oxygen saturation after the use of surgical mask, even significant, would not be clinical relevant, since the blood oxygen saturation remained in normal range (90–98%) [17] , fact also applicated to the HR that was maintained in normal resting values (60–100 bpm) [18] . Only when the use of mask is maintained in time (over 8h in healthcare professionals) symptoms of hypoxemia such as chest discomfort and tachypnoea are presented [19] . These response could be explained sine CO2 is a respiratory stimulant, and when is accumulated by the mask use increase lung ventilation and respiratory activity, fact that would explain the symptoms of confusion, impaired cognition, and disorientation, experienced by nurses [13] .…”

Section: Discussionmentioning

confidence: 99%

Cognitive and psychophysiological impact of surgical mask use during university lessons

Tornero-Aguilera

Clemente‐Suárez

2021

Physiology & Behavior

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Section: Discussionmentioning

confidence: 99%

Cognitive and psychophysiological impact of surgical mask use during university lessons

Tornero-Aguilera

Clemente‐Suárez

2021

Physiology & Behavior

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“…Some social media accounts connected heavier breathing while wearing FFR with the false claim to reduce blood oxygen saturation. Indeed, respiration behavior (amongst others, frequency and intensity, see 37 for a review) changes while wearing an FFR (especially during exercise), and the physical dead volume of the respiratory system causes breathing to be more strenuous 38 . However, there is no evidence that wearing face masks (cloth/surgical masks or FFR) causes the blood oxygen levels to diminish 22 – 24 , 26 , 27 , 29 .…”

Section: Introductionmentioning

confidence: 99%

The tiny effects of respiratory masks on physiological, subjective, and behavioral measures under mental load in a randomized controlled trial

Spang

Pieper

2021

Sci Rep

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Since the outbreak of the coronavirus disease (COVID-19), face coverings are recommended to diminish person-to-person transmission of the SARS-CoV-2 virus. Some public debates concern claims regarding risks caused by wearing face masks, like, e.g., decreased blood oxygen levels and impaired cognitive capabilities. The present, pre-registered study aims to contribute clarity by delivering a direct comparison of wearing an N95 respirator and wearing no face covering. We focused on a demanding situation to show that cognitive efficacy and individual states are equivalent in both conditions. We conducted a randomized-controlled crossover trial with 44 participants. Participants performed the task while wearing an N95 FFR versus wearing none. We measured physiological (blood oxygen saturation and heart rate variability), behavioral (parameters of performance in the task), and subjective (perceived mental load) data to substantiate our assumption as broadly as possible. We analyzed data regarding both statistical equivalence and differences. All of the investigated dimensions showed statistical equivalence given our pre-registered equivalence boundaries. None of the dimensions showed a significant difference between wearing an FFR and not wearing an FFR.Trial Registration: Preregistered with the Open Science Framework: https://osf.io/c2xp5 (15/11/2020). Retrospectively registered with German Clinical Trials Register: DRKS00024806 (18/03/2021).

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“…The microfluidic integration to the SiNW-FETs allows a controlled supply of fluids containing target molecules of interest. Concerning commercial applications of SiNW-FETs, the microfluidic integration of such sensors allows automated fluid handling, which enables high throughput and low-cost analyses [ 91 ]. Microfluidic channels of dimensions of several 10 s up to 100 s of micrometers are typically used for fluidic integration of biosensors to handle small quantities of analyte samples allowing for rapid and low-cost analysis.…”

Section: System Integrationmentioning

confidence: 99%

Process Variability in Top-Down Fabrication of Silicon Nanowire-Based Biosensor Arrays

Tintelott

Pachauri

Ingebrandt

et al. 2021

Sensors

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Silicon nanowire field-effect transistors (SiNW-FET) have been studied as ultra-high sensitive sensors for the detection of biomolecules, metal ions, gas molecules and as an interface for biological systems due to their remarkable electronic properties. “Bottom-up” or “top-down” approaches that are used for the fabrication of SiNW-FET sensors have their respective limitations in terms of technology development. The “bottom-up” approach allows the synthesis of silicon nanowires (SiNW) in the range from a few nm to hundreds of nm in diameter. However, it is technologically challenging to realize reproducible bottom-up devices on a large scale for clinical biosensing applications. The top-down approach involves state-of-the-art lithography and nanofabrication techniques to cast SiNW down to a few 10s of nanometers in diameter out of high-quality Silicon-on-Insulator (SOI) wafers in a controlled environment, enabling the large-scale fabrication of sensors for a myriad of applications. The possibility of their wafer-scale integration in standard semiconductor processes makes SiNW-FETs one of the most promising candidates for the next generation of biosensor platforms for applications in healthcare and medicine. Although advanced fabrication techniques are employed for fabricating SiNW, the sensor-to-sensor variation in the fabrication processes is one of the limiting factors for a large-scale production towards commercial applications. To provide a detailed overview of the technical aspects responsible for this sensor-to-sensor variation, we critically review and discuss the fundamental aspects that could lead to such a sensor-to-sensor variation, focusing on fabrication parameters and processes described in the state-of-the-art literature. Furthermore, we discuss the impact of functionalization aspects, surface modification, and system integration of the SiNW-FET biosensors on post-fabrication-induced sensor-to-sensor variations for biosensing experiments.

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Erratum to: No training required: experimental tests support homology-based DNA assembly as a best practice in synthetic biology

Cited by 7 publications

References 1 publication

Cognitive and psychophysiological impact of surgical mask use during university lessons

Cognitive and psychophysiological impact of surgical mask use during university lessons

The tiny effects of respiratory masks on physiological, subjective, and behavioral measures under mental load in a randomized controlled trial

Process Variability in Top-Down Fabrication of Silicon Nanowire-Based Biosensor Arrays

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