Erratum to: New approaches to countermeasures of the negative effects of micro-gravity in long-term space flights

Kozlovskaya, I. B.; Sayenko, Irina; Miller, T. F.; Khusnutdinova, Dilyara; Melnik, K.A.; Popov, D. V.; Виноградова, О. Л.; Yarmanova, E. N.; Tomilovskaya, Elena

doi:10.1016/j.actaastro.2006.09.038

Cited by 11 publications

(16 citation statements)

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“…A decrease of transverse stiffness in m.soleus in this group reached significance only by the 6th day of DI; at the same time decrease of EMG amplitude at rest and maximal isokinetic force of m.triceps surae as well as signs of hyperreflexia and changes in MU recruitment order were not registered at all (Grigoriev et al, 2004; Khusnutdinova et al, 2004; Miller et al, 2004, 2005, 2010; Netreba et al, 2004, 2005, 2006; Kozlovskaya et al, 2007a,b; Shigueva et al, 2015a; Zakirova et al, 2015). Analogous effects of mechanical stimulation of the soles support zones were demonstrated in the structure of the muscular apparatus: no decrease of myofibrils’ sensitivity to free calcium ions, which is regularly observed under conditions of gravitational unloading; no changes in the cross sectional area of muscle fibers; and no decrease of the number of fibers containing slow isoforms of heavy myosin chains (Grigoriev et al, 2004; Moukhina et al, 2004; Shenkman et al, 2004a,b).…”

Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 88%

“…Similarly, studies of resting state brain activity revealed the changes similar to those obtained in a real space flight, indicating that support withdrawal is the main contributor to brain activity alterations and decline in the function of corticospinal tract function in weightlessness (Kuznetsova et al, 2015; Lazarev et al, 2018). Interestingly, support stimulation under DI conditions also eliminated these changes, although to a lesser extent than peripheral ones (Kozlovskaya et al, 2007a,b).…”

Section: Effects On the Sensory-motor Systemmentioning

confidence: 88%

“…The results of these studies confirmed the hypothesis that support afferentation plays the trigger role in the system of postural tonic control. The aforementioned changes in leg muscle functions were not observed in participants in whom the mechanical stimulation of the soles support zones during DI exposure was applied (Kozlovskaya et al, 2007a,b).…”

Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 94%

“…The sensitivity to proprioceptive signals was also changed: exposure to DI was associated with the development of H-reflex system hypersensitivity, which was demonstrated by a decrease of the soleus H-reflex thresholds and an increase of relative H-reflex amplitudes (Kozlovskaya et al, 2007a; Saenko, 2007; Zakirova et al, 2015).…”

Section: Effects On the Sensory-motor Systemmentioning

confidence: 99%

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Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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Dry immersion (DI) is one of the most widely used ground models of microgravity. DI accurately and rapidly reproduces most of physiological effects of short-term space flights. The model simulates such factors of space flight as lack of support, mechanical and axial unloading as well as physical inactivity. The current manuscript gathers the results of physiological studies performed from the time of the model’s development. This review describes the changes induced by DI of different duration (from few hours to 56 days) in the neuromuscular, sensory-motor, cardiorespiratory, digestive and excretory, and immune systems, as well as in the metabolism and hemodynamics. DI reproduces practically the full spectrum of changes in the body systems during the exposure to microgravity. The numerous publications from Russian researchers, which until present were mostly inaccessible for scientists from other countries are summarized in this work. These data demonstrated and validated DI as a ground-based model for simulation of physiological effects of weightlessness. The magnitude and rate of physiological changes during DI makes this method advantageous as compared with other ground-based microgravity models. The actual and potential uses of the model are discussed in the context of fundamental studies and applications for Earth medicine.

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Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 88%

Section: Effects On the Sensory-motor Systemmentioning

confidence: 88%

Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 94%

Section: Effects On the Sensory-motor Systemmentioning

confidence: 99%

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Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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“…Supportlessness immediately induces a marked decrease in muscle tone. The dramatic loss of postural muscle tone is one of the early manifestations of exposure to dry immersion (Gevlich et al 1983;Kozlovskaia 2008;Kozlovskaya et al 1988Kozlovskaya et al , 2007a. For the postural muscles, the 40-50% drop in tone occurs within the first few hours of dry immersion (Gevlich et al 1983;Kozlovskaya 2002;Kozlovskaia et al 1984).…”

Section: Muscle Tone and Afferent Inputmentioning

confidence: 96%

Long-term dry immersion: review and prospects

et al. 2010

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Dry immersion, which is a ground-based model of prolonged conditions of microgravity, is widely used in Russia but is less well known elsewhere. Dry immersion involves immersing the subject in thermoneutral water covered with an elastic waterproof fabric. As a result, the immersed subject, who is freely suspended in the water mass, remains dry. For a relatively short duration, the model can faithfully reproduce most physiological effects of actual microgravity, including centralization of body fluids, support unloading, and hypokinesia. Unlike bed rest, dry immersion provides a unique opportunity to study the physiological effects of the lack of a supporting structure for the body (a phenomenon we call 'supportlessness'). In this review, we attempt to provide a detailed description of dry immersion. The main sections of the paper discuss the changes induced by long-term dry immersion in the neuromuscular and sensorimotor systems, fluid-electrolyte regulation, the cardiovascular system, metabolism, blood and immunity, respiration, and thermoregulation. The long-term effects of dry immersion are compared with those of bed rest and actual space flight. The actual and potential uses of dry immersion are discussed in the context of fundamental studies and applications for medical support during space flight and terrestrial health care.

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