Erratum to: Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Hayes, Wesley; Boyle, Sheila; Carroll, Adrian; Böckenhauer, Detlef; Marks, Stephen D.

doi:10.1007/s00467-017-3609-4

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mg supplemen- tation to type II diabetic patients resulted in improved glycemic control [15]. Hypomagnesemia early posttransplant was shown to be an independent predictor of new onset diabetes after transplantation [16][17][18]; however, the association between hypomagnesemia and new onset diabetes after transplantation remains controversial due to conflicting findings [12,19,20].…”

Section: Introductionmentioning

confidence: 99%

Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation

Isakov

Patibandla

Christopher

et al. 2022

Kidney Blood Press Res

View full text Add to dashboard Cite

BACKGROUND: Post-transplant hypomagnesemia is commonly observed among patients prescribed CNIs. METHODS: We conducted a retrospective single center analysis (2000-2013, N=726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium level of all measured magnesium levels from 1 month to 1 year post-transplant was calculated. RESULTS: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall survival and death with a functioning graft increased by 11%, 14% and 12% respectively (p < 0.01). In a multivariate model, patients with median Mg level ≥ 1.7 mg/dL had a reduced overall survival rate (HR 1.57, 95% CI 1.04-2.38, p = 0.033) compared to those with median Mg level < 1.7 mg/dL. This association was observed in subgroups of patients above 60 years old, in those who had a slow graft function (SGF) and in females. CONCLUSIONS: Post-transplant hypomagnesemia is associated with better patient and allograft survival up to 10 years post-transplant. This relationship remained significant after accounting for baseline allograft function, presence of slow graft function (SGF) and CNI trough levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation

Isakov

Patibandla

Christopher

et al. 2022

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Up to 30% of adolescents with CF will develop CF-related diabetes [44]. Although a diagnosis of CF-related diabetes prior to transplantation increased the risk of death while awaiting lung transplantation, it had no impact on survival after transplantation [45]. Among adults without diabetes before lung transplantation, a diagnosis of CF increased the risk of developing diabetes by 3.3 times [46].…”

Section: Introductionmentioning

confidence: 99%

Post-Transplantation Diabetes Mellitus in Pediatric Patients

Wolfsdorf

Marks

2020

Horm Res Paediatr

View full text Add to dashboard Cite

More than 80% of pediatric solid organ transplant (SOT) recipients now survive into young adulthood and many encounter transplant-related complications. Post-transplantation diabetes mellitus (PTDM), sometimes also referred to as post-transplant diabetes or new onset diabetes after transplant, occurs in 3–20% of pediatric SOT recipients depending upon the organ transplanted, age at transplantation, immunosuppressive regimen, family history, and time elapsed since transplant. To diagnose PTDM, hyperglycemia must persist beyond the initial hospitalization for transplantation when a patient is on stable doses of immunosuppressive medications. Though standard diagnostic criteria used by the American Diabetes Association (ADA) to diagnose diabetes are employed, clinicians need to be aware of the limitations of using these criteria in this unique patient population. Management of PTDM parallels strategies used for type 2 diabetes (T2D), while also carefully considering comorbidities and potential interactions with immunosuppressive medications in these patients. In caring for patients with PTDM, it is important to be familiar with these interactions and comorbidities in order to coordinate care with the transplant team and optimize outcomes for these patients.

show abstract

“…Separately, hypomagnesemia has been shown to decrease insulin sensitivity [21], indicating that hypomagnesemia is a potential cause of impaired glucose tolerance. Moreover, hypomagnesemia during the first month posttransplant was shown to be an independent predictor of new-onset diabetes following transplantation [22][23][24], a frequent complication which has been associated with adverse graft and cardiovascular outcomes [25,26].…”

Section: Introductionmentioning

confidence: 99%

Posttransplantation Hypomagnesemia as a Predictor of Better Graft Function after Transplantation

Hod¹,

Isakov²,

Patibandla³

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

Background: Hypomagnesemia is frequently seen after transplantation and is particularly associated with the use of calcineurin inhibitors (CNIs). Methods: We conducted a retrospective, single-center analysis (2000–2013, N = 726) to explore the relationship between hypomagnesemia and long-term allograft outcome in kidney transplant recipients. For this study, a median serum magnesium (Mg) level of all measured Mg levels from 1 month to 1 year after renal transplantation was calculated. Results: For every increase in Mg by 0.1 mg/dL, the GFR decreased by 1.1 mL/min at 3 years posttransplant (p < 0.01) and by 1.5 mL/min at 5 years posttransplant. A median blood Mg level of ≥1.7 was found to be an independent predictor of a GFR <60 mL/min at 3 years posttransplant. The odds of having a GFR <60 mL/min 3 years posttransplant was almost 2-fold higher in the high Mg group than in the low Mg group. Conclusions: Hypomagnesemia from 1 to 12 months after renal transplantation is associated with a better allograft function up to 5 years posttransplant. This relationship was found to hold true after accounting for baseline allograft function and the presence of slow graft function.

show abstract

Erratum to: Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Abstract: The last sentence of the second paragraph of the Results section should read: Fourteen patients developed NODAT between 8 and 30 days post transplantation, five of whom required insulin therapy for > 12 months.

Cited by 3 publications

References 0 publications

Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation

Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation

Post-Transplantation Diabetes Mellitus in Pediatric Patients

Posttransplantation Hypomagnesemia as a Predictor of Better Graft Function after Transplantation

Contact Info

Product

Resources

About