Erratum to: Generation of Pig iPS Cells: A Model for Cell Therapy

Montserrat, Núria; Bahima, Elena Garreta; Batlle, Laura; Häfner, Sophia; Rodrigues, Alexandre Miguel Cavaco; González, Federico; Belmonte, Juan Carlos Izpisúa

doi:10.1007/s12265-012-9403-6

Cited by 1 publication

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“…Usually for the pPSC culturing, standard human stem cell medium [69] or mouse and human standard culturing medium are mixed in 1:1 ratio [8] [77] because of the paucity of the information related to presence of receptors on pPSCs [35] demonstrated that porcine pluripotent cell lines do not express LIF receptors [13]. However, they do express FGFR-2 [13].…”

Section: Culture Conditionsmentioning

confidence: 99%

<i>In Pursuit</i> of Porcine Pluripotent Stem Cells for Autologous Cell Therapy

Verma¹,

Mehta²,

Pal³

et al. 2014

SCD

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Treatments to repair the human heart following regenerative diseases remain a challenge for medical science. Unlike lower vertebrate species the human heart lacks a regenerative pathway meaning that research has to be focused on cell transplantation. Porcines (Sus scrofa) are excellent models for cardiovascular disease and pluripotent stem cells (PSCs) generated from porcines will provide important clinical insights for cardiac cell therapy. This could open a new avenue of research into degenerative conditions as porcine is a more effective human proxy to work with. However, bona fide PSCs are currently available only in rodents (mouse, rat) and primates (monkey, human). Attempts to derive pluripotent stem cells (PSCs) from porcine have been going on for more than two decades with slow progress. Despite the fact that the porcine stem cells are under increasing glare of publicity due to milestone achievements in this area of research. Advances in stem cell technology, especially the genetic engineering, innovative cell culturing and induced pluripotency to generate stem cells has dramatically revolutionized the basic and applied investigations and applications of porcine stem cells. This review attempts to summarize the major signaling pathways involved in maintenance of pluripotency and the state of the art conceptual and technical progress for generating bona fide porcine PSCs.

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