Erratum to “Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use” [Chemosphere 40 (2000) 783–793]

Stuer‐Lauridsen, Frank; Birkved, Morten; Hansen, Lisbet; Lützhøft, H.-C. Holten; Halling-Sørensen, Bent

doi:10.1016/s0045-6535(00)00152-1

Cited by 11 publications

(7 citation statements)

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“…Because SAs are water soluble and demonstrate little chelating ability and have a low binding constant for soil, 27 they have the potential to enter groundwater and surface water rapidly. 27,28 TCs, however, have been shown to be strong chelators 9,23 and sorb to soil strongly. 27 Furthermore, Stuer-Lauidsen et al 28 found that despite a low octanol-water partitioning coefficient of 0.026 for oxytetracycline, the soil distribution coefficient in sludge was 1990.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Trace Levels of Sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water Using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry

2001

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A method has been developed for the trace analysis of two classes of antimicrobials consisting of six sulfonamides (SAs) and five tetracyclines (TCs), which commonly are used for veterinary purposes and agricultural feed additives and are suspected to leach into ground and surface water. The method used solid-phase extraction and liquid chromatography/mass spectrometry (LC/MS) with positive ion electrospray. The unique combination of a metal chelation agent (Na2EDTA) with a macroporous copolymer resulted in quantitative recoveries by solid-phase extraction (mean recovery, 98 +/- 12%) at submicrogramper-liter concentrations. An ammonium formate/formic acid buffer with a methanol/water gradient was used to separate the antimicrobials and to optimize the signal intensity. Mass spectral fragmentation and ionization characteristics were determined for each class of compounds for unequivocal identification. For all SAs, a characteristic m/z 156 ion representing the sulfanilyl fragment was identified. TCs exhibited neutral losses of 17 amu resulting from the loss of ammonia and 35 amu from the subsequent loss of water. Unusual matrix effects were seen only for TCs in this first survey of groundwater and surface water samples from sites around the United States, requiring that TCs be quantitated using the method of standard additions.

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Section: Resultsmentioning

confidence: 99%

Analysis of Trace Levels of Sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water Using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry

2001

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“…This can be attributed to the particular sorption mechanism of FQs, which seems to occur mainly by the effects of electrostatic interactions, although hydrophobic forces are apparently also involved (25,26,33). Therefore, to evaluate the sorption properties of FQs, experimental solidwater partition coefficients (Kd) with a strict control over pH conditions are necessary, as suggested by some authors (27,34).…”

Section: Resultsmentioning

confidence: 99%

Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil

Golet

Xifra

Siegrist

et al. 2003

Environ. Sci. Technol.

638

306

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The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical-biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88-92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log Kd approximately 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil.

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“…Both natural and synthetic estrogens are widely used in human and veterinary medicine as contraceptives and growth promoters and to treat some human cancers [3,4]. For these reasons, estrogens are now considered to be the most prescribed drugs in the world [5]. Estrogens can suffer several transformations in the body such as hydroxylation, oxidation, and biotransformations producing sulfate and glucuronide metabolites [6], which are also important to study because they can deconjugate into free estrogens in the environment [7].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted solid-phase extraction coupled with ultra high performance liquid chromatography and fluorescence detection for the determination of estrogens and their metabolites in wastewater

et al. 2015

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Estrogens are an important class of endocrine-disrupting compounds, and their contamination of environmental waters through the effluents of wastewater treatment plants could have an important impact on aquatic biota, even at low concentrations. For this reason, the development of selective and sensitive extraction methodologies, which permit the identification and quantification of these compounds at trace level concentrations, is very important. In this study, a quantitative method based on molecularly imprinted solid phase extraction coupled to ultra high performance liquid chromatography with fluorescence detection has been developed. It has been used for the simultaneous determination of three estrogens and two of their metabolites in water samples from wastewater treatment plants. The method developed presents satisfactory limits of detection (between 0.18 and 0.45 ng·mL ), good recoveries (higher than 60%) and low relative standard deviations (under 10%). The method was used to analyze wastewater from a veterinary hospital as well as influent and effluent samples of a wastewater treatment plant of Gran Canaria (Spain) The concentrations of the detected hormones ranged from 1.35 to 2.57 ng·mL .

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Erratum to “Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use” [Chemosphere 40 (2000) 783–793]

Cited by 11 publications

References 0 publications

Analysis of Trace Levels of Sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water Using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry

Analysis of Trace Levels of Sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water Using Solid-Phase Extraction and Liquid Chromatography/Mass Spectrometry

Environmental Exposure Assessment of Fluoroquinolone Antibacterial Agents from Sewage to Soil

Molecularly imprinted solid-phase extraction coupled with ultra high performance liquid chromatography and fluorescence detection for the determination of estrogens and their metabolites in wastewater

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