Erratum to: Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized “Z” Studies

Abstract

Author wants to correct the text under the heading of Introduction. The sentence is written as: ''In the ZENITH study, both treatments had a similar positive effect on regression of cardiac and renal damage, whereas a larger proportion of patients showing carotid plaque regression was observed under zofenopril (31.6% vs. 16.1%; p = 0.047), particularly in the subgroup of patients taking the low dose of zofenopril (30 mg) plus HCTZ 12.5 mg (4.7% vs 10.0% irbesartan 150 mg plus HCTZ 12.5 mg; p = 0.043)''. The correct sentence should read: ''In the ZENITH study, both treatments had a similar positive effect on regression of cardiac The online version of the original article can be found under

Zofenopril: Blood pressure control and cardio-protection

“…A pooled analysis of the results of the Z-studies (n = 1469) confirmed the efficacy of both combinations on office and ambulatory BPs after 18–24 weeks, with similar reductions over 24 h and over the last 6 h, both with the high and low dose combinations [ 33 ]. The analysis of data from the low-dose subgroups (corresponding to the currently available doses on the market) showed a higher efficacy of zofenopril 30 mg + HCTZ 12.5 mg vs. irbesartan 150 mg + HCTZ 12.5 mg in the ZODIAC study in terms of office DBP reductions (19.8 vs. 14.5 mmHg, p = 0.022).…”

“…The primary efficacy criteria were, for all studies, the effects of the drugs on office BP; in the ZEUS study, the effect on ambulatory BP was also assessed (through ambulatory BP monitoring [ABPM]). In 2 studies, ZODIAC and ZENITH, the long-term effects of the drugs were also evaluated [ 33 ].…”

“…3 ). For the low-dose subgroup, also the percentage of patients showing daytime SBP normalization (< 135 mmHg) and response (SBP < 135 mmHg or reduction > 10 mmHg) at study end was significantly larger under zofenopril (88.9% and 91.7%) than under irbesartan (73.2% and 78.0%; p = 0.017 and p = 0.024, respectively) [ 33 ].…”

“…As far as the safety profile is concerned, in the Z-studies the total number of adverse events, as well as the proportion of treatment-related adverse events, was limited and similar between the two treatments (25.2% of patients receiving zofenopril and 21.9% of patients receiving irbesartan; p = 0.715) [ 33 ]. This is consistent with the safety profile of the zofenopril + HCTZ combination derived from clinical trials, in which it was associated with a low percentage of treatment withdrawals [ 26 ].…”

“…Similarly, in the Z-studies, only 66 (4.3%) patients were withdrawn from the studies because of an adverse event — 38 in the zofenopril (4.9%) and 28 in the irbesartan treatment group (3.6%; p = 0.593). The most common drug-related adverse event observed under zofenopril was cough (1.8% of patients), whereas dizziness was the most prevalent drug adverse reaction in irbesartan-treated patients (1.4%) [ 33 ].…”