Erratum to: Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

Cimino, Luca; Aldigeri, Raffaella; Marchi, Silvia; Mastrofilippo, Valentina; Viscogliosi, Fabiana; Coassin, Marco; Soldani, Annamaria; Savoldi, Luisa; Fanti, Alessandro De; Belloni, Lucia; Zerbini, Alessandro; Parmeggiani, Maria; Chersich, Matthew; Soriano, Alessandra; Salvarani, Carlo; Fontana, Luigi

doi:10.1007/s10792-017-0466-x

Cited by 13 publications

(16 citation statements)

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“…From recent studies [71] we know that the prevalence of infectious uveitis is increasing, representing 30% of all cases in Italy; tuberculosis and syphilis accounted for 20% and almost 3% of infectious etiologies, respectively. On the other hand, the prevalence of ocular toxoplasmosis has reduced in recent years from 6.9% to 4.7%; this finding is probably due also to prenatal screening and testing.…”

Section: Resultsmentioning

confidence: 99%

The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

Pirani

Pelliccioni

Turris

et al. 2019

JCM

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Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluation and with the aid of a multimodal imaging examination. Methods: We hereby describe selected cases who came to our attention and were visited in our eye clinic. In all clinics, the use of retinal and optic disc multimodal imaging during ophthalmological evaluation allowed to make a diagnosis of an infectious disease. Results: In our tertiary referral center more than 60 patients with syphilis, tuberculosis and toxoplasmosis have been evaluated in the last two years: In 60% of cases the ophthalmological evaluation was secondary to a previous diagnosis of an infectious disease, while in the remaining cases the ophthalmologist, with the help of a multimodal imaging examination and clinical evaluation, represented the physician who leads to the diagnosis. Conclusion: Our results confirm how in these life-threatening pathologies a prompt diagnosis is mandatory and may benefit from a multidisciplinary and multimodal imaging approach, especially during ophthalmological evaluation.

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Section: Resultsmentioning

confidence: 99%

The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

Pirani

Pelliccioni

Turris

et al. 2019

JCM

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“…A recent review performed from 1976 to 2017 on observational data from patients with uveitis in Europe [49] revealed that anterior uveitis accounted for 53.2% of 24,126 uveitis patients from studies performed in 20 European countries, including Spain, the mean age of the patients being 40 years (ranging 31 to 48 years) and women accounting for 52% of these patients, similarly to the data presented herein. In total, 990 cases of uveitis were identified in Italy from 2013 to 2015, these being mostly females (59%) with a median age at presentation of 44 years, and anterior uveitis was reported as the most frequent clinical type (53.5%) [50]. Brydak-Godowska et al [49] analyzed data from 26 published studies with a total of 24,126 uveitis patients from 12 European countries, showing that idiopathic uveitis was the most common form (55.5%), while in our study idiopathic uveitis accounted for 60% of the cohort.…”

Section: Discussionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

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The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (−) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10−5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10−4), and TNFα (p = 2 × 10−4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10−7) and IL-6 (p = 3 × 10−6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.

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“…Other international studies have found that the percentage of pan-uveitis cases proven to be secondary to sarcoidosis range from 0.6% to 38% in different countries, with the highest frequencies seen in Turkey, Germany, Italy, and Sri Lanka. 10 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 In Japan, suspected sarcoidosis accounts for 22.3% of all uveitis cases. Sarcoidosis is also the most common final diagnosis (40.7%) in cases of pan-uveitis of unknown initial etiology.…”

Section: Discussionmentioning

confidence: 99%

“… 13 However, these estimates are highly variable and differ substantially in endemic countries. 10 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 Herein, we report an unusual case of sarcoid-associated acute pan-uveitis that imitated the presentation of fungal endophthalmitis in a patient with no known history of sarcoidosis.…”

Section: Introductionmentioning

confidence: 97%

Yet another case of ocular sarcoidosis

Hien

Onghanseng

Than

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To report a case of bilateral pan-uveitis resembling fungal and viral endophthalmitis in a patient who was ultimately diagnosed with sarcoidosis. Observation A 64-year-old female presented with a four-day history of painless vision loss in the right eye. She presented with multiple concurrent systemic complaints, including a history of oral and genital sores, patches of hypopigmented skin on her forearms, and occasional shortness of breath. Upon further examination, she was noted to have bilateral pan-uveitis, which was more severe in the right than left eye. Posterior pole examination of the right eye revealed dense vitritis with multiple large whitish round balls that seemed suggestive of fungal or viral endophthalmitis. Initial therapies included intravitreal (IVT) foscarnet and intravenous (IV) acyclovir, followed by IV amphotericin B and oral voriconazole, which did not improve ocular signs and symptoms. Further evaluations ruled out infectious etiologies and lymphoma. Chest computerized tomography (CT) scan revealed findings suggestive of sarcoidosis, which was confirmed with lung biopsy. Anti-viral and -fungal treatments were discontinued, and the patient was started on IV methylprednisolone followed by oral prednisone and mycophenolate mofetil. Ocular symptoms improved, and the patient remained stable after treatment. Conclusion and Importance The index report illustrates a case of ocular sarcoidosis that imitated the presentation of infectious endophthalmitis. Though ocular sarcoidosis is known to masquerade as a range of disorders and constitutes part of the differential diagnosis for infectious endophthalmitis, sarcoidosis has not been reported in recent literature to imitate the presentation of fungal endophthalmitis. The index case suggests that ocular sarcoidosis should be considered in the differential diagnoses of fungal endophthalmitis.

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Erratum to: Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

Abstract: In the original publication, the author names were published incorrectly. The names have been corrected in this erratum.

Cited by 13 publications

References 0 publications

The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

Yet another case of ocular sarcoidosis

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