Erratum to: “Antagonistic effects of Satureja hortensis essential oil against AFB1, on human lymphocytes in vitro”

Çeker, Selçuk; Ağar, Güleray; Alpsoy, Lokman; Nardemir, Gokce; Kızıl, Hamit Emre

doi:10.3103/s0095452715010120

Cited by 3 publications

(4 citation statements)

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“…Ceker et al [ 63 ] studied the effects of SHEO against aflatoxin B1 (AFB1) in human lymphocytes in vitro. The results suggested strong antioxidative and antigenotoxic effects, expressed by the decrease of sister chromatid exchange and micronuclei, as well as malondialdehyde, superoxide dismutase and glutathione peroxidase levels, increased as a result of the AFB1 action.…”

Section: Biological Activities Of Satureja Hortensis mentioning

confidence: 99%

“…Pure SHEO has an oral of 1370 mg/kg (rats) and a dermal toxicology of 340 mg/kg (guinea pig) [ 77 ], Buckle [ 78 ] estimating a 19 mL oral lethal dose for a child. Due to its particular scent, SHEO found application in perfumery industry [ 79 ] and beverage industry (for the production of vermouth) [ 80 ], besides the classical application in food industry or in commercial spice mixtures for sausages, pâtés or pickles [ 63 ].…”

Section: Dosage Toxicology Popular and Emerging Usesmentioning

confidence: 99%

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Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade

et al. 2018

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Satureja hortensis L. (summer savory) is an annual herbaceous crop, native to Europe and in our days spread and used all over the world. Although its use as spice and medicinal plant is known since ancient times, peer-reviewed studies presenting the scientific data are scarce. The natural products obtained from summer savory (extracts and essential oil) are dominated by polyphenols and flavonoids, responsible for their antioxidant, antimicrobial, antiparasitic, pesticidal, anti-inflammatory, analgesic, hepatoprotective and anticancer properties, among others. The current study presents the progress made in the last decade regarding the potential applications of summer savory, being the first review study focused on S. hortensis, in the same time suggesting future research opportunities, as they appear from the properties of other Satureja species. The available data presenting the properties of summer savory represents a scientific support for application in industry, for developing “clean label” food products.

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Section: Biological Activities Of Satureja Hortensis mentioning

confidence: 99%

Section: Dosage Toxicology Popular and Emerging Usesmentioning

confidence: 99%

Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade

et al. 2018

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“…Neither extract of the selected Satureja species had cytostatic and cytotoxic effects in human lymphocytes in vitro. The possible dose-dependent protective and antitumor activity should be further investigated considering the previous studies on related Satureja species [19,20] and the known antigenotoxic effects of rosmarinic [14] and caffeic acids [16].…”

mentioning

confidence: 99%

Satureja subspicata and S. horvatii Extracts Induce Overexpression of the BCl-2 Family of Anti-apoptotic Genes and Reduce Micronuclei Frequency in Mice

Čakar

Lojo

Haverić

et al. 2018

Natural Product Communications

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Satureja subspicata and S. horvatii are endemic species of the Balkan Peninsula and often used in traditional medicine in Bosnia and Herzegovina to treat different health conditions. We aimed to analyze the unevaluated apoptotic, genotoxic and cytotoxic effects of two Satureja species, as well as their content of phenolics that are mainly responsible for the plant's biological activity. Apoptotic and geno/cytotoxic activities of S. subspicata and S. horvatii were investigated in vitro in human lymphocyte culture and in vivo in mice. The content of the main phenolics in plant extracts was determined by ultra-high pressure liquid chromatography-MS-MS (UHPLC–MS/MS). Genotoxic and cytotoxic activities of Satureja extracts were evaluated in vitro by applying a cytokinesis-block micronucleus cytome assay in human lymphocyte culture and in vivo applying a mice reticulocytes micronucleus assay. SALSA RT-MLPA R011-C1 apoptosis assay was used for measuring the relative expression of 44 genes associated with the regulation of the apoptotic pathways in human lymphocyte cultures treated with different concentrations of two Satureja extracts. The first analysis of phenolic compounds in S. horvatii and S. subspicata determined by an UHPLC-MS/MS method revealed high levels of rosmarinic and caffeic acids. Minor genotoxic potential was determined in relation to the tested concentrations while no cytostatic and cytotoxic effects were revealed in vitro. However, when applied in concentrations of 200 mg/kg per os, aqueous extracts of two Satureja species significantly decreased frequency of reticulocytes micronuclei in treated mice against controls. Extracts of S. subspicata and S. horvatii in concentrations of 0.2 mg/mL, regardless of solvent used, downregulated pro-apoptotic and upregulated anti-apoptotic genes, showing anti-apoptotic activity. Our results indicate that the registered anti-genotoxic and anti-apoptotic activity is most likely related to the high level of phenolic acids (particularly rosmarinic and caffeic) in the tested extracts.

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“…Hazırlanan preparatlar üç gün oda sıcaklığında bekletilerek yaşlandırıldı. Bu süre sonunda her bir preparat floresan plus giemsa tekniği ile boyandı [12].…”

Section: Lenfosit Kültürüunclassified

Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri

Çeker¹,

Orhan²,

Güllüce³

et al. 2017

Muş Alparslan Üniversitesi Fen Bilimleri Dergisi

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Bitkilerden elde edilen, özellikle fenolik yapıdaki kimyasal maddeler, antioksidan özellikleri sayesinde reaktif oksijen türlerini inaktive ederek oksidatif hasarın önlenmesinde ve giderilmesinde önemli rol oynamaktadırlar. Buna karşın günümüzde, bitkisel ürünlerin çoğunun yapıları ve biyolojik etkinlikleri yeterince aydınlatılamamış olup, birçok bitkisel antioksidan maddenin toksisitesi ve insan sağlığına olan zararlarlarıyla ilgili çalışmalar yeterli değildir. Bu çalışma, Mentha longifolia L. Hudson ssp. longifolia bitkisinden izole edilen iki fenolik bileşik olan Apigenin-7-O-glikozit (A7G) ile Apigenin-7-O-rutinozit (A7R)'in genotoksik ve anti-genotoksik etkilerinin belirlenmesi üzerine tasarlanmıştır. İki fenolik bileşiğin, insan lenfosit hücrelerinde aflatoksin B1'e (AFB1) karşı genotoksik ve anti-genotoksik etkileri kardeş kromatid değişimi testi ile araştırılmıştır. Çalışma sonuçları A7G ve A7R'nin güçlü anti-genotoksik özelliklerinin olduğunu göstermiştir.

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Erratum to: “Antagonistic effects of Satureja hortensis essential oil against AFB1, on human lymphocytes in vitro”

Cited by 3 publications

References 0 publications

Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade

Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade

Satureja subspicata and S. horvatii Extracts Induce Overexpression of the BCl-2 Family of Anti-apoptotic Genes and Reduce Micronuclei Frequency in Mice

Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri

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