Erratum to “A T cell-binding fragment of fibrinogen can prevent autoimmunity” [J. Autoimmun. 34 (2010) 453–459]

Targeting fibrin in neurodegeneration

“…Due to the many differences between rodents and humans, for example with respect to immune function 13 , a note of caution is warranted, and the data should be validated in human systems. Furthermore, interactions of a fibrin γC peptide truncated at position 399 have been shown to inhibit T cell activation 14 and, on the other hand, fibrin aids in the host defense against bacteria via both innate and T cell-mediated mechanisms 15 . Targeting a specific site of fibrin that separates different functions of this pleiotropic mediator therefore holds great promise, but the effects of 5B8 could be even broader than indicated by the study of Akassoglou and colleagues 1 and should be followed carefully during clinical development for effects and adverse events.…”