Erratum: State-Dependent Partial Occlusion of Cortical LTP-Like Plasticity in Major Depression

Kühn, Marion; Mainberger, Florian; Feige, Bernd; Maier, Jonathan G.; Mall, Volker; Jung, Nicolai H; Reis, Janine; Klöppel, Stefan; Normann, Claus; Nissen, Christoph

doi:10.1038/npp.2016.97

Cited by 12 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduction of PAS-induced LTP-like plasticity in the motor cortex in MDD before the interventions confirms findings of previous studies ( 2 , 6 ), and different mechanisms may account for this. First, changes in structural and functional synaptic plasticity, such as reduced synaptic density in dorsolateral prefrontal cortex (DLPFC), the anterior corpus callosum (ACC), and the hippocampus ( 5 , 50 , 51 ) are described in MDD, likely leading to reduced functional connectivity within and between networks underlying mood and cognition.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies using PAS ( 6 ) and measures of synaptic density ( 5 ) have described an association between the severity of depressive symptoms and neuroplasticity in MDD. We extended these findings in our study by showing that the amount of LTP-like plasticity strongly correlates with the BDI-II scores in both groups at baseline; and further, that the amount of BDI-II score reduction and the increase of PAS plasticity seen after the interventions were correlated in both groups, though stronger in the PA.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced LTP-like plasticity in the motor cortex has been described in MDD in studies using paired associative stimulation (PAS) as a specific transcranial magnetic stimulation (TMS) protocol ( 2 , 6 ), which tests synaptic plasticity in the human brain ( 7 ). As this reduction showed some association with the symptom severity measured in clinical scales, developing interventions that aim at enhancing synaptic plasticity might be of crucial relevance in the treatment of MDD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression

et al. 2021

View full text Add to dashboard Cite

Major depressive disorder (MDD) is the most common mental disorder and deficits in neuroplasticity are discussed as one pathophysiological mechanism. Physical activity (PA) enhances neuroplasticity in healthy subjects and improves clinical symptoms of MDD. However, it is unclear whether this clinical effect of PA is due to restoring deficient neuroplasticity in MDD. We investigated the effect of a 3-week PA program applied on clinical symptoms, motor excitability and plasticity, and on cognition in patients with MDD (N = 23), in comparison to a control intervention (CI; N = 18). Before and after the interventions, the clinical symptom severity was tested using self- (BDI-II) and investigator- (HAMD-17) rated scales, transcranial magnetic stimulation (TMS) protocols were used to test motor excitability and paired-associative stimulation (PAS) to test long-term-potentiation (LTP)-like plasticity. Additionally, cognitive functions such as attention, working memory and executive functions were tested. After the interventions, the BDI-II and HAMD-17 decreased significantly in both groups, but the decrease in HAMD-17 was significantly stronger in the PA group. Cognition did not change notably in either group. Motor excitability did not differ between the groups and remained unchanged by either intervention. Baseline levels of LTP-like plasticity in the motor cortex were low in both groups (PA: 113.40 ± 2.55%; CI: 116.83 ± 3.70%) and increased significantly after PA (155.06 ± 10.48%) but not after CI (122.01 ± 4.1%). Higher baseline BDI-II scores were correlated with lower levels of neuroplasticity. Importantly, the more the BDI-II score decreased during the interventions, the stronger did neuroplasticity increase. The latter effect was particularly strong after PA (r = −0.835; p < 0.001). The level of neuroplasticity related specifically to the psychological/affective items, which are tested predominantly in the BDI-II. However, the significant clinical difference in the intervention effects was shown in the HAMD-17 which focuses more on somatic/neurovegetative items known to improve earlier in the course of MDD. In summary, PA improved symptoms of MDD and restored the deficient neuroplasticity. Importantly, both changes were strongly related on the individual patients' level, highlighting the key role of neuroplasticity in the pathophysiology and the clinical relevance of neuroplasticity-enhancing interventions for the treatment of MDD.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the early 1900s Sigmund Freud already hypothesized that an alteration of the experience-dependent mechanisms shaping brain networks may be involved in the pathogenesis of mental disorders, describing the neural processes underlying conscious and unconscious memory long before the description of synaptic plasticity [ 185 ]. To date, many clinical reports support this view, since synaptic plastic properties have been found altered in several psychiatric conditions such as Major Depressive Disorder (MDD) [ 186 , 187 ], bipolar disorders [ 188 , 189 ] and schizophrenia [ 190 , 191 ]. Preclinical studies further support the relevance of dysfunctional synaptic transmission in mental disorders, suggesting possible novel synapto-centric therapeutic approaches [ 192 , 193 , 194 , 195 ].…”

Section: Molecular and Electrophysiological Correlates Of Synaptic Dysfunction Underlying Psychiatric Symptoms In Cns Disordersmentioning

confidence: 99%

Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis

Menculini

Chipi

Paoletti

et al. 2021

IJMS

View full text Add to dashboard Cite

Different psychopathological manifestations, such as affective, psychotic, obsessive-compulsive symptoms, and impulse control disturbances, may occur in most central nervous system (CNS) disorders including neurodegenerative and neuroinflammatory diseases. Psychiatric symptoms often represent the clinical onset of such disorders, thus potentially leading to misdiagnosis, delay in treatment, and a worse outcome. In this review, psychiatric symptoms observed along the course of several neurological diseases, namely Alzheimer’s disease, fronto-temporal dementia, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, are discussed, as well as the involved brain circuits and molecular/synaptic alterations. Special attention has been paid to the emerging role of fluid biomarkers in early detection of these neurodegenerative diseases. The frequent occurrence of psychiatric symptoms in neurological diseases, even as the first clinical manifestations, should prompt neurologists and psychiatrists to share a common clinico-biological background and a coordinated diagnostic approach.

show abstract

“…Elevated levels of pro-inflammatory cytokines in the brain also interfere with long-term potentiation (LTP), ,,− a synaptic event responsible for strengthening synaptic transmission, which underlies memory formation and learning . LTP is impaired in patients with MDD, which may be a consequence of the elevated levels of proinflammatory cytokines characteristic of depressed individuals. Indeed, studies have demonstrated that peripheral injections of bacterial lipopolysaccharide (LPS), an endotoxin on Gram-negative bacteria that is used to elicit inflammation and produce a rapid elevation of levels of proinflammatory cytokines in circulation, reduce LTP in the hippocampus .…”

Section: Chronic Stress and Proinflammatory Cytokinesmentioning

confidence: 99%

Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity

Caracci

Harary

Simkovic

et al. 2019

J. Agric. Food Chem.

View full text Add to dashboard Cite

Major depressive disorder (MDD) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels in sensitive brain regions associated with depression. Elevated levels of proinflammatory cytokines and reduced BDNF levels lead to impaired synaptic plasticity mechanisms that contribute to the pathophysiology of MDD. There is accumulating evidence that the administration of polyphenols at doses ranging from 5 to 180 mg/kg of body weight can normalize elevated levels of proinflammatory cytokines and abnormal levels of BDNF and, thus, restore impaired synaptic plasticity mechanisms that mediate depressive behavior in animal models of stress. This review will focus on the mechanisms by which grape-derived polyphenols normalize impaired synaptic plasticity and reduce depressive behavior in animal models of stress.

show abstract

Erratum: State-Dependent Partial Occlusion of Cortical LTP-Like Plasticity in Major Depression

Abstract: In this article, coauthors Mailies Wirminghaus 1 and Lotte Limbach 1 , whose names were inadvertently omitted from the byline, are now included.

Cited by 12 publications

References 0 publications

Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression

Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression

Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis

Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity

Contact Info

Product

Resources

About