Erratum: Peripheral administration of lactate produces antidepressant-like effects

Abstract

Correction to: Molecular Psychiatry advance online publication, 18 October 2016; doi:10.1038/mp.2016.179 Following publication of the above article, the authors noticed that an obsolete version of the Supplementary Information file was published. The correct version of the file accompanies this erratum online.

Modifying the maternal microbiota alters the gut–brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams

“…While a direct link between maternal microbiota and increased brain lactate has not been reported, the importance of maternal microbiota and microbial metabolites in neurodevelopment during the perinatal period is recognized ( 24 ). l -lactate has antidepressant-like properties when administered to adult mice ( 49 , 50 ), and the selective serotonin reuptake inhibitor fluoxetine has been shown to increase lactate release from astrocytes in vitro ( 51 ). Functioning independently as both a signaling molecule ( 33 ) and neuronal energy source ( 52 , 53 ), the pleiotropic properties of lactate may have contributed to the early life changes in NMDAR gene expression ( 54 ) and behavior ( 49 , 50 ).…”

“…l -lactate has antidepressant-like properties when administered to adult mice ( 49 , 50 ), and the selective serotonin reuptake inhibitor fluoxetine has been shown to increase lactate release from astrocytes in vitro ( 51 ). Functioning independently as both a signaling molecule ( 33 ) and neuronal energy source ( 52 , 53 ), the pleiotropic properties of lactate may have contributed to the early life changes in NMDAR gene expression ( 54 ) and behavior ( 49 , 50 ). Here, the abundance of brain lactate, but not other brain metabolites, correlated highly with GLUN2A/2B and PFKFB3 expression changes across all young male and female offspring and correlated with reduced anxiety-like behavior in both young and adult offspring.…”

Pierre J. Magistretti

“…Thirty-five years on, I have continued to collaborate with Jean-Luc Martin. We currently are collaborating on the role of lactate, the metabolite formed by glycogenolysis in astrocytes, as an antidepressant agent, a recent result that I will discuss later (Carrard et al, 2016). As to Patrick Hof, after a couple of years in my lab, he joined John Morrison's group at Scripps Research Institute, where Floyd's lab had moved from Salk in 1985.…”

A combined metabolomics and molecular biology approach to reveal hepatic injury and underlying mechanisms after chronic l-lactate exposure in mice

“…In the brain, systemic delivery of l- lactate through intraperitoneal injections induces hippocampal expression of brain-derived neurotrophic factor (BDNF) and improves learning and memory creation [10] . In mice, peripheral administration of l- lactate also produces antidepressant-like effects, especially in terms of serotonin receptor trafficking, astrocyte functions, neurogenesis, nitric oxide synthesis, and cAMP signaling [11] . In skeletal muscle, l- lactate controls the expression of several proteins involved in mitochondrial biogenesis [12] , while in adipose tissue, extracellular l- lactate mediates antilipolytic action by activating the Gi-coupled receptor GPR81 via downregulation of cAMP levels [13] or p38-MAPK-dependent FGF21 expression [14] .…”