Erratum: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

Abstract

In the version of this article initially published, the Myc-Ub label in Figure 3c was incorret. Arrowheads were missing in fig. 5d and 5e. A plus (+) was misplaced from the curve in Fig. 7c. The correct versions of these figures are shown below.

Dehydrogenase/reductase SDR family member�2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression

“…A set of transcriptional factors have been implicated in the regulation of EMT, including Snail, Slug, ZEB1, and Twist (39). Among them, Snail and Slug are degraded by ubiquitination via the proteasome pathway resulting in E-cadherin expression (40,41). It has been revealed that MDM2, one of the E3 ligases of p53, reduces lung cancer mobility and metastasis through mediation of Slug degradation via the ubiquitination proteasome pathway (41,42).…”

“…Among them, Snail and Slug are degraded by ubiquitination via the proteasome pathway resulting in E-cadherin expression (40,41). It has been revealed that MDM2, one of the E3 ligases of p53, reduces lung cancer mobility and metastasis through mediation of Slug degradation via the ubiquitination proteasome pathway (41,42). Accordingly, it was speculated that DHRS2 expression may prompt the migration of CRC cells by interacting with E3 ubiquitin ligase MDM2 and interfere with its function which suppresses degradation of EMT-inducing transcriptional factor Slug/Snail.…”