Erratum: Non-motor features of Parkinson disease

Schapira, Anthony H.V.; Chaudhuri, K. Ray; Jenner, Peter

doi:10.1038/nrn.2017.91

Cited by 193 publications

(106 citation statements)

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“…Non-motor symptoms such as depression, constipation, sleep disorders and circadian rhythm dysfunction are frequently seen in PD patients (Tadaiesky et al 2008; Willison et al 2013; Schapira et al 2017). In the present study, PD rats displayed the reduced exploratory activity and preferred to stay in local area in the open field test.…”

Section: Discussionmentioning

confidence: 99%

“…Circadian rhythm disruption is a major non-motor symptom in PD patients (Schapira et al 2017; Willison et al 2013). In ROT-induced PD rat model, circadian rhythms were disrupted (Lax et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The CLOCK-BMAL1 heterodimer also governs the robustly circadian expression of nuclear orphan receptors Rev-Erbα (Nr1d1) and the PAR-bZip family members Dbp (Mohawk et al 2012; Partch et al 2014). Aberrant expression of circadian clock genes could result in dysregulated circadian rhythm at earlier stages of PD and the progression of the disease (Videnovic and Willis 2016; Schapira et al 2017). …”

Section: Introductionmentioning

confidence: 99%

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Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Song

Wang

et al. 2018

Neurotox Res

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A single injection of LPS produced low-grade neuroinflammation leading to Parkinson’s disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and whether such low-grade neuroinflammation would aggravate rotenone (ROT) neurotoxicity and disrupts circadian clock gene/protein expressions were examined in this study. Male rats were given two injections of LPS (2.5–7.5 mg/kg), and neuroinflammation and dopamine neuron loss were evident 3 months later. Seven months after a single LPS (5 mg/kg) injection, rats received low doses of ROT (0.5 mg/kg, sc, 5 times/week for 4 weeks) to examine low-grade neuroinflammation on ROT toxicity. LPS plus ROT produced more pronounced non-motor and motor dysfunctions than LPS or ROT alone in behavioral tests, and decreased mitochondrial complex 1 activity, together with aggravated neuroinflammation and neuron loss. The expressions of clock core genes brain and muscle Arnt-like protein-1 (Bmal1), locomotor output cycles kaput (Clock), and neuronal PAS domain protein-2 (Npas2) were decreased in LPS, ROT and LPS plus ROT groups. The expressions of circadian feedback genes Periods (Per1 and Per2) were also decreased, but Cryptochromes (Cry1 and Cry2) were unaltered. The circadian clock target genes nuclear receptor Rev-Erbα (Nr1d1), and D-box-binding protein (Dbp) expressions were also decreased. Consistent with the transcript levels, circadian clock protein BMAL1, CLOCK, NR1D1 and DBP were also decreased. Thus, LPS-induced chronic low-grade neuroinflammation potentiated ROT neurotoxicity and disrupted circadian clock gene/protein expression, suggesting a role of disrupted circadian in PD development and progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Song

Wang

et al. 2018

Neurotox Res

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“…Recent findings have suggested that non-motor symptoms are prevalent and severe in patients with PD (Schapira et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously reported that HRQOL and motor symptoms were not necessarily correlated despite the significant improvement in motor functions, suggesting that nonmotor symptoms might affect HRQOL after DBS . Among several non-motor symptoms, urinary symptoms are known to be prevalent and severe in PD patients (Schapira, Chaudhuri, & Jenner, 2017). However, temporal changes in urinary symptoms and their relationship to HRQOL after DBS are unknown.…”

Section: Introductionmentioning

confidence: 99%

Urinary symptoms are correlated with quality of life after deep brain stimulation in Parkinson's disease

et al. 2018

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AimsDeep brain stimulation (DBS) is known to dramatically improve motor complications in patients with Parkinson's disease (PD), but its effect on urinary symptoms and health‐related quality of life (HRQOL) remains unknown. We aimed to examine the relationship between urinary symptoms and HRQOL in patients with PD who underwent DBS.MethodsThe International Prostate Symptom Score (IPSS) and overactive bladder symptom score (OABSS) were determined to evaluate urinary symptoms in patients with PD who underwent DBS. Postoperative evaluations were performed at 3 months, 1 year, and 3 years postoperatively. We also performed a urodynamic study (UDS) in 13 patients with PD preoperatively and postoperatively. A follow‐up UDS was performed 2.0 ± 0.5 years postoperatively.ResultsThe preoperative urinary symptoms questionnaire was completed by 28 patients, of whom 14 completed the postoperative urinary symptoms questionnaire after 3 months, 18 after 1 year, and 10 after 3 years. The mean OABSS and IPSS did not change significantly at any follow‐up periods postoperatively. When assessing the relationship between urinary symptoms and HRQOL and motor functions, the OABSS and IPSS showed significant positive correlations with HRQOL at 3 months postoperatively. The OABSS and IPSS showed significant positive correlations with activities of daily living (ADL) during the off‐phase at 3 years postoperatively. All urodynamic parameters remained unchanged postoperatively.ConclusionsDeep brain stimulation did not significantly affect urinary dysfunctions in patients with PD. Urinary symptoms might partially contribute to HRQOL at 3 months postoperatively and ADL during the off‐phase at 3 years postoperatively.

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An Intelligent Neural Stem Cell Delivery System for Neurodegenerative Diseases Treatment

Qiao

Liu

Han

et al. 2018

Adv Healthcare Materials

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Transplanted stem cells constitute a new therapeutic strategy for the treatment of neurological disorders. Emerging evidence indicates that a negative microenvironment, particularly one characterized by the acute inflammation/immune response caused by physical injuries or transplanted stem cells, severely impacts the survival of transplanted stem cells. In this study, to avoid the influence of the increased inflammation following physical injuries, an intelligent, double-layer, alginate hydrogel system is designed. This system fosters the matrix metalloproeinases (MMP) secreted by transplanted stem cell reactions with MMP peptide grafted on the inner layer and destroys the structure of the inner hydrogel layer during the inflammatory storm. Meanwhile, the optimum concentration of the arginine-glycine-aspartate (RGD) peptide is also immobilized to the inner hydrogels to obtain more stem cells before arriving to the outer hydrogel layer. It is found that blocking Cripto-1, which promotes embryonic stem cell differentiation to dopamine neurons, also accelerates this process in neural stem cells. More interesting is the fact that neural stem cell differentiation can be conducted in astrocyte-differentiation medium without other treatments. In addition, the system can be adjusted according to the different parameters of transplanted stem cells and can expand on the clinical application of stem cells in the treatment of this neurological disorder.

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Erratum: Non-motor features of Parkinson disease

Cited by 193 publications

References 1 publication

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

Urinary symptoms are correlated with quality of life after deep brain stimulation in Parkinson's disease

An Intelligent Neural Stem Cell Delivery System for Neurodegenerative Diseases Treatment

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