Erratum: MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells

Cui, J; Yang, Yuchao; Li, H; Leng, Y; Qian, K; Huang, Qi-Yuan; Lu, Z; Chen, J; Sun, T; Wu, R; Sun, Y; Song, H; Wei, X; Jing, P; Yang, X; Zhang, Chenyu

doi:10.1038/onc.2015.201

Cited by 20 publications

(7 citation statements)

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“…40 Indeed, upregulation of aromatase expression is found in tamoxifen-resistant human breast cancer. 23 Moreover, our results also indicated that forced CREB1 expression increased aromatase expression. Notably, recent evidence suggests that miR-27b-3p enhances cytotoxicity of drugs by targeting inhibition of ENPP1, which induces ABCG2 expression and cell surface localization and increases drugs efflux.…”

Section: Discussionsupporting

confidence: 60%

“…22, 23, 24 Downregulation of miR-375 and miR-873 are associated with tamoxifen resistance, whereas overexpression of miR-375 and miR-873 increases tamoxifen sensitivity in breast cancer. 22, 23 In this study, we identified miR-27b-3p exhibited decreased expression in tamoxifen-resistant breast cancer tissues and cells. In addition, we had shown for the first time the role of miR-27b-3p in conferring sensitivity of breast cancer to tamoxifen.…”

Section: Discussionmentioning

confidence: 99%

“…38, 39 Besides, emerging evidence has suggested that CREB1 enhanced aromatase transactivation in breast cancer cells. 23 Aromatase as a key enzyme for the biosynthesis of estrogens enhances breast cancer cells resistance to tamoxifen. 40 Indeed, upregulation of aromatase expression is found in tamoxifen-resistant human breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

et al. 2016

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Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those patients with ERα-positive breast cancer. However, a majority of patients with ERα positive fail to respond to tamoxifen due to the presence of intrinsic or acquired resistance to the drug. Altered expression and functions of microRNAs (miRNAs) have been reportedly associated with tamoxifen resistance. In this study, we investigated the role of miR-27b-3p in resistance of breast cancer to tamoxifen. MiR-27b-3p levels were remarkably reduced in the tamoxifen-resistant breast cancer cells compared with their parental cells. In addition, miR-27b-3p was also significantly downregulated in breast tumor tissues relative to adjacent non-tumor tissues. Moreover, the expression levels of miR-27b-3p were lower in the breast cancer tissues from tamoxifen-resistant patients compared with that from untreated-tamoxifen patients. Notably, tamoxifen repressed miR-27b-3p expression, whereas estrogen induced miR-27b-3p expression in breast cancer cells. Besides, we provided experimental evidences that miR-27b-3p enhances the sensitivity of breast cancer cells to tamoxifen in vitro and in vivo models. More importantly, we validated that miR-27b-3p directly targeted and inhibited the expression of nuclear receptor subfamily 5 group A member 2 (NR5A2) and cAMP-response element binding protein 1 (CREB1) and therefore augmented tamoxifen-induced cytotoxicity in breast cancer. Lastly, miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues. Our findings provided further evidence that miR-27b-3p might be considered as a novel and potential target for the diagnosis and treatment of tamoxifen-resistant breast cancer.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

et al. 2016

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“…miR-323 was shown to upregulate VEGF-A and increase vascularization in prostate cancer [30]. In a recent study, miR-873 was shown to be downregulated in breast tumors and to play a tumor suppressor role by targeting cyclin-dependent kinase 3, leading to the inhibition of ER-α activity and the suppression of breast cancer cell proliferation and tumor growth [31]. Insulin-like growth factor 2 mRNA binding protein 1 (IGFBP1) was identified as a target of miR-873 in glioblastoma [32].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-873 is a Potential Serum Biomarker for the Detection of Ectopic Pregnancy

Yan²,

Xu³

et al. 2017

Cell Physiol Biochem

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Background: Ectopic pregnancy (EP) refers to the implantation of the zygote outside the uterine cavity. In clinical practice, the diagnosis of EP relies on a combination of ultrasound findings and serum human chorionic gonadotrophin (hCG) measurements. However, the need for serial hCG measurements increases the risk of tubal rupture and death, underscoring the need to identify biomarkers for the early detection of EP. Methods: The serum concentrations of 21 microRNAs (miRNAs) associated with pregnancy or with known placental expression, as well as serum hCG and progesterone levels were analyzed 36 patients with viable intrauterine pregnancy (VIP), 30 patients with spontaneous abortion (SA), and 34 patients with EP using specific assay kits and reverse transcription PCR. The diagnostic performance of the different serum markers for detecting EP was analyzed by ROC curve analysis. Results: Five miRNAs were differentially expressed between the three groups, of which miR-873 and miR-223 were significantly lower in EP than in VIP and SA patients and did not change significantly according to gestational age, and miR-323 was significantly higher in EP than in VIP and SA. As a single marker, miR-873 had the highest sensitivity for detecting EP at 61.76% (at a fixed specificity of 90%). In comparison, the combination of hCG, progesterone and miR-873 had the highest sensitivity for detecting EP at 79.41% (at a fixed specificity of 90%). Conclusion: Although further validation in large-scale prospective studies is necessary, our results suggest that miR-873 could be a valuable noninvasive and stable biomarker for the early detection of EP.

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“… 20 , 21 , 22 Cui et al. 23 have shown that miR-873-5p attenuates tamoxifen resistance by targeting CDK3 and modulates ERα transcriptional activity in breast cancer cells. We recently indicate that miR-873-5p suppresses the stemness of breast cancer cells through targeting PD-L1, an immune checkpoint, and thus suppressing the PI3K/AKT and ERK1/2 signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity

Guo

Wang

Yang

et al. 2020

Molecular Therapy - Nucleic Acids

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Transcription factor Yin Yang 1 (YY1) is upregulated in multiple tumors and plays essential roles in tumor proliferation and metastasis. However, the function of YY1 in breast cancer stemness remains unclear. Herein, we found that YY1 expression was negatively correlated with the overall survival and relapse-free survival of breast cancer patients and positively correlated with the expression of stemness markers in breast cancer. Overexpression of YY1 increased the expression of stemness markers, elevated CD44 + CD24 − cell sub-population, and enhanced the capacity of cell spheroid formation and tumor-initiation. In contrast, YY1 knockdown exhibited the opposite effects. Mechanistically, YY1 decreased microRNA-873-5p (miR-873-5p) level by recruiting histone deacetylase 4 (HDAC4) and HDAC9 to miR-873-5p promoter and thus increasing the deacetylation level of miR-873-5p promoter. Sequentially, YY1 activated the downstream PI3K/AKT and ERK1/2 pathways, which have been confirmed to be suppressed by miR-873-5p in our recent work. Moreover, the suppressed effect of YY1/miR-873-5p axis on the stemness of breast cancer cells was partially dependent on PI3K/AKT and ERK1/2 pathways. Finally, it was found that the YY1/miR-873-5p axis is involved in the chemoresistance of breast cancer cells. Our study defines a novel YY1/miR-873-5p axis responsible for the stemness of breast cancer cells.

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Erratum: MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells

Cited by 20 publications

References 0 publications

Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

MicroRNA-873 is a Potential Serum Biomarker for the Detection of Ectopic Pregnancy

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity

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