Erratum: microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney

Office, Frontiers Production

doi:10.3389/fphar.2020.00011

Cited by 31 publications

(25 citation statements)

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“…A recent study evaluated the frequency of the rs776746 polymorphism and its association with hypertension in eight indigenous populations from Mexico. 53 The analysis report that the CYP3A5*3/*3 genotype frequencies ranged from 23.5% in Mexicaneros to 93.3% in Mayos, and the mean observed in the Mexican indigenous groups was 67.5% (very similar to the frequency found in the Native Americans of our study). Also, Galaviz-Hernandez et al found that the CYP3A5*3/*3 genotype was more frequent in indigenous women with higher systolic and diastolic blood pressures values.…”

Section: Discussionsupporting

confidence: 87%

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

Fernandes¹,

Rodrigues²,

Maroñas³

et al. 2021

PGPM

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Introduction: The genetic admixture of the Brazilian population has considerable relevance to the implementation of the principles of pharmacogenomics (PGx), as it may compromise the extrapolation of data obtained in more homogeneous world populations. Purpose: This study aims to investigate a panel of 117 polymorphisms in 35 pharmacogenes, which contains label recommendations or clinical evidence by international drug regulatory agencies, in Amazonian Native American populations, and compare the results obtained with continental population data from the 1000 Genomes Project Consortium. Patients and Methods: The study population is composed of 109 Native American individuals from three Brazilian Amazon groups. The genotyping of the PGx polymorphisms was performed by allelic discrimination using TaqMan ® OpenArray Genotyping with a panel of 120 customized assays on the QuantStudio™ 12K Flex Real-Time PCR System. Results: Statistical differences within the Native American populations were observed regarding both genotypes and phenotypes of some genes of the CYP family. The discriminant analysis of principal components (DAPCs) between the NAM group and the continental populations of the 1000 Genomes Project resulted in the clustering of the three Native American populations. Additionally, in general, the NAM group was determined to be closely situated between East Asia, America, and South Asia groups, which enabled us to infer a genetic similarity between these populations. The DAPC analysis further demonstrated that eight polymorphisms and six polymorphisms were more relevant in differentiating the NAM from the continental populations and the NAM populations among themselves, respectively. Conclusion: Some investigated polymorphisms show differences among world populations, particularly with populations of European origin, for whom precision medicine protocols are primarily designed. The accumulated knowledge regarding these variations may assist in the design of specific protocols for Native American populations and populations admixed with them.

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Section: Discussionsupporting

confidence: 87%

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

Fernandes¹,

Rodrigues²,

Maroñas³

et al. 2021

PGPM

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“… 54 Recent studies indicated that ZnO NPs destroy cancer cells through ROS generation. 14 , 55 Oxidative stress generating potential of ZnO NPs, SnO 2 -ZnO NPs, and SnO 2 -ZnO/rGO NCs in MCF-7 cells were explored through measuring several markers of pro-oxidants and antioxidants. Figure 9A depicted that all three samples induce ROS generation dose-dependently.…”

Section: Resultsmentioning

confidence: 99%

SnO2-Doped ZnO/Reduced Graphene Oxide Nanocomposites: Synthesis, Characterization, and Improved Anticancer Activity via Oxidative Stress Pathway

Ahamed

Akhtar

Khan

et al. 2021

IJN

104

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“… 11 − 19 Several vaccine candidates are currently being investigated in Phase 3 clinical trials including two mRNA-based vaccines and two virally vectored vaccines. 20 − 22 Importantly, the mRNA vaccine candidates rely on lipid–nanoparticle encapsulation and require long-term cold-chain storage (−20 to −80 °C), 20 , 21 leading to extensive logistical challenges for distribution and administration. Virus-based vaccines including inactivated, live-attenuated, and recombinant viral vaccines can produce robust immune responses, but are known to induce off-target vector-directed immune responses 23 , 24 and can be associated with more frequent side effects and adverse events.…”

Section: Introductionmentioning

confidence: 99%

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

et al. 2021

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The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying one of two multimerized SARS-CoV-2 spikes: full-length ectodomain (S-Fer) or a C-terminal 70 amino-acid deletion (SΔC-Fer). Ferritin is an attractive nanoparticle platform for production of vaccines, and ferritin-based vaccines have been investigated in humans in two separate clinical trials. We confirmed proper folding and antigenicity of spike on the surface of ferritin by cryo-EM and binding to conformation-specific monoclonal antibodies. After a single immunization of mice with either of the two spike ferritin particles, a lentiviral SARS-CoV-2 pseudovirus assay revealed mean neutralizing antibody titers at least 2-fold greater than those in convalescent plasma from COVID-19 patients. Additionally, a single dose of SΔC-Fer elicited significantly higher neutralizing responses as compared to immunization with the spike receptor binding domain (RBD) monomer or spike ectodomain trimer alone. After a second dose, mice immunized with SΔC-Fer exhibited higher neutralizing titers than all other groups. Taken together, these results demonstrate that multivalent presentation of SARS-CoV-2 spike on ferritin can notably enhance elicitation of neutralizing antibodies, thus constituting a viable strategy for single-dose vaccination against COVID-19.

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Erratum: microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney

Cited by 31 publications

References 0 publications

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

SnO2-Doped ZnO/Reduced Graphene Oxide Nanocomposites: Synthesis, Characterization, and Improved Anticancer Activity via Oxidative Stress Pathway

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

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