Erratum in “Successful desensitisation to ceftriaxone in a patient with doxycycline resistant Lyme disease”

Rodrigues, Jorge; Cruz, L; Botelho, C.; Rio, Edite; Castel-Branco, M.G.

doi:10.1016/j.aller.2009.06.002

Cited by 2 publications

(1 citation statement)

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“…Desensitization for type I hypersensitivity reactions in penicillin‐allergic patients was first developed more than 50 years ago (88). Other empiric protocols were developed to treat hypersensitivity reactions to essential drugs that could not be substituted, such as antibiotics (89–102), allopurinol (103), aspirin (104) and clopidogrel (105), insulin (106), chemotherapy agents (107, 108), and biologics (109, 110). Secondary prevention relies mainly on identification of allergic patients, avoidance of the culprit drug and drugs that cross‐react and use of a Medic‐Alert bracelet (8).…”

Section: Management Of Anaphylaxismentioning

confidence: 99%

Anaphylaxis: past, present and future

Ben‐Shoshan

Clarke

2010

Allergy

157

142

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To cite this article: Ben‐Shoshan M, Clarke AE. Anaphylaxis: past, present and future. Allergy 2011; 66: 1–14. Abstract Anaphylaxis is a clinical emergency, and recent reports suggest increased prevalence. A diverse set of primary genetic and environmental influences may confer susceptibility to anaphylactic reactions. Anaphylaxis presents diagnostic and therapeutic challenges. It often manifests with a broad array of symptoms and signs that might be similar to other diseases. The management of anaphylaxis consists of emergency treatment of acute episodes as well as preventive strategies to avoid recurrences. Treatment is complicated by its rapid onset and progression, presence of concurrent diseases or medications, and need for long‐term allergen avoidance. Health care professionals must be able to recognize the signs of anaphylaxis, treat an episode promptly and appropriately, and provide preventive recommendations. Recognizing the gaps in our understanding and management of anaphylaxis may help identify promising targets for future treatment and prevention and areas that require further study.

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Section: Management Of Anaphylaxismentioning

confidence: 99%

Anaphylaxis: past, present and future

Ben‐Shoshan

Clarke

2010

Allergy

157

142

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Desensitization to antibiotics in children

Cernadas

2012

Pediatric Allergy Immunology

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Drug hypersensitivity reactions can occur to almost all drugs and antibiotics are among the most common cause for this kind of reactions. Drug hypersensitivity may affect any organ or system, and manifestations range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the suspected drug is avoided in the future. In case of infection, there is usually a safe antibiotic alternative. Nonetheless, in some cases, no alternative treatment exists for optimal therapy. Under these circumstances, desensitization may be performed. Drug desensitization is defined as the induction of a temporary state of tolerance to a drug which can only be maintained by continuous administration of the medication responsible for the hypersensitivity reaction. Desensitization is mainly performed in IgE-mediated reactions. Increasing doses of the implicated drug are administered over a short period of time, until the therapeutic dose is achieved and tolerated. Very few studies confined to children are found in literature. Most of them are case reports. In general, the proposed desensitization schemes are similar to those used in adults differing only in the final dose administered. The purpose of this study is to review desensitization to antibiotics in children presenting and discussing three clinical practical cases of desensitization in this age group.

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Erratum in “Successful desensitisation to ceftriaxone in a patient with doxycycline resistant Lyme disease”

Cited by 2 publications

References 0 publications

Anaphylaxis: past, present and future

Anaphylaxis: past, present and future

Desensitization to antibiotics in children

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