“…In addition, IL-1F5, which has been shown to exert receptor antagonist activities, has been renamed IL-36Ra. 15 Currently, little is known regarding the expression pattern and the biologic function of IL-36␣, IL-36, and IL-36␥. Messenger RNAs for these cytokines are highly expressed in only a few tissues, particularly in internal epithelial tissues, which are exposed to pathogens and in skin.…”